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Using primary care data to assess comparative effectiveness and safety of apixaban and rivaroxaban in patients with nonvalvular atrial fibrillation in the UK: an observational cohort study
Conclusions Among patients with nonvalvular AFib, apixaban was as effective as rivaroxaban in reducing rate of stroke and safer in terms of major bleeding episodes. This head-to-head comparison supports conclusions drawn from indirect comparisons of DOAC trials against warfarin and demonstrates the potential for real-world evidence to fill evidence gaps and reduce uncertainty in both health technology assessment decision-making and clinical guideline development.
Source: BMJ Open - October 17, 2022 Category: General Medicine Authors: Jaksa, A., Gibbs, L., Kent, S., Rowark, S., Duffield, S., Sharma, M., Kincaid, L., Ali, A. K., Patrick, A. R., Govil, P., Jonsson, P., Gatto, N. Tags: Open access, Cardiovascular medicine Source Type: research

Two-year outcomes of UK patients newly diagnosed with atrial fibrillation: findings from the prospective observational cohort study GARFIELD-AF
CONCLUSION: The data support a benefit of anticoagulation in reducing stroke and death, without an increased risk of a major bleed in patients with new-onset AF. Anticoagulation treatment in patients at high risk of stroke who are not receiving anticoagulation may further improve outcomes.PMID:35577587 | DOI:10.3399/BJGP.2021.0548
Source: The British Journal of General Practice - May 16, 2022 Category: Primary Care Authors: Patricia N Apenteng Saverio Virdone Fd Richard Hobbs A John Camm Keith Aa Fox Karen S Pieper Gloria Kayani David Fitzmaurice GARFIELD UK investigators* Source Type: research

Thromboembolic and haemorrhagic events in patients with atrial fibrillation: a prospective cohort study in UK primary and secondary care.
CONCLUSION: Anticoagulants are associated with lower risk of thromboembolic and haemorrhagic events among patients with AF than antiplatelets. More research is required on the risk associated with VKAs or NOACs. PMID: 31015222 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - April 22, 2019 Category: Primary Care Authors: Robson J, Mathur R, Priebe M, Ahmed Z, Ayerbe L Tags: Br J Gen Pract Source Type: research

Incidence of epilepsy and associated factors in elderly patients in Germany
ConclusionsThe incidence of epilepsy was high and increased with age in elderly patients followed in general practices in Germany. Addressing identified risk factors may help reduce the risk of developing epilepsy.
Source: Epilepsy and Behavior - December 5, 2018 Category: Neurology Source Type: research

Incidence of epilepsy and associated factors in elderly patients in Germany.
CONCLUSIONS: The incidence of epilepsy was high and increased with age in elderly patients followed in general practices in Germany. Addressing identified risk factors may help reduce the risk of developing epilepsy. PMID: 30529258 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - December 4, 2018 Category: Neurology Authors: Jacob L, Bohlken J, Schmitz B, Kostev K Tags: Epilepsy Behav Source Type: research

Low-dose aspirin and risk of intracranial bleeds: An observational study in UK general practice
Conclusion: Low-dose aspirin is not associated with an increased risk of any type of ICB and is associated with a significantly decreased risk of SAH when used for ≥1 year.
Source: Neurology - November 27, 2017 Category: Neurology Authors: Cea Soriano, L., Gaist, D., Soriano-Gabarro, M., Bromley, S., Garcia Rodriguez, L. A. Tags: All Cerebrovascular disease/Stroke, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research

New oral anticoagulants for nonvalvular atrial fibrillation in the elderly: Limited applicability in primary care.
CONCLUSION: There is uncertainty about effectiveness and safety of NOACs in unselected elderly patients with AF in primary care. Therefore, the balance between benefit and harm is still unclear. For this reason, routine use of NOACs is not recommended in elderly patients in primary care. PMID: 25495417 [PubMed - in process]
Source: European Journal of General Practice - December 4, 2015 Category: Primary Care Tags: Eur J Gen Pract Source Type: research

Clinical Manifestation of Depression after Stroke: Is It Different from Depression in Other Patient Populations?
Conclusions The findings suggest that depression after stroke is not a different type of depression. This finding indicates that all depressive symptoms should be evaluated in stroke patients, including somatic symptoms.
Source: PLoS One - December 4, 2015 Category: Biomedical Science Authors: Janneke M. de Man-van Ginkel et al. Source Type: research

Migraine and risk of hemorrhagic stroke: a study based on data from general practice
Conclusion No clear increased risk of ICH or SAH was observed in migraineurs.
Source: The Journal of Headache and Pain - November 11, 2014 Category: Neurology Source Type: research

Cardiovascular, Bleeding, and Mortality Risks in Elderly Medicare Patients Treated with Dabigatran or Warfarin for Non-Valvular Atrial Fibrillation.
CONCLUSIONS: -In general practice settings, dabigatran was associated with reduced risk of ischemic stroke, intracranial hemorrhage, and death, and increased risk of major gastrointestinal hemorrhage compared with warfarin in elderly patients with non-valvular AF. These associations were most pronounced in patients treated with dabigatran 150 mg twice daily, whereas the association of 75 mg twice daily with study outcomes was indistinguishable from warfarin except for a lower risk of intracranial hemorrhage with dabigatran. PMID: 25359164 [PubMed - as supplied by publisher]
Source: Circulation - October 30, 2014 Category: Cardiology Authors: Graham DJ, Reichman ME, Wernecke M, Zhang R, Southworth MR, Levenson M, Sheu TC, Mott K, Goulding MR, Houstoun M, MaCurdy TE, Worrall C, Kelman JA Tags: Circulation Source Type: research

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