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Condition: Hemorrhagic Stroke
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Total 250 results found since Jan 2013.

Safety of Novel Oral Anticoagulants Compared With Uninterrupted Warfarin for Catheter Ablation of Atrial Fibrillation.
CONCLUSIONS: Compared with warfarin, periprocedural anticoagulation with dabigatran resulted in fewer minor hemorrhages and total adverse events after AF ablation. Patients anticoagulated with NOACs required larger doses of heparin and took longer to reach the goal ACT compared with patients anticoagulated with warfarin. PMID: 25515868 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - December 16, 2014 Category: Drugs & Pharmacology Authors: Armbruster HL, Lindsley JP, Moranville MP, Habibi M, Khurram IM, Spragg DD, Berger RD, Calkins H, Marine JE Tags: Ann Pharmacother Source Type: research

Iodinated Contrast Prior to Thrombolysis Was Not Associated With Worse Intracranial Hemorrhage
ConclusionsNo consistent harms were observed in association with intravenous iodinated contrast prior to rt‐PA administration. It is reasonable to continue CTA prior to thrombolysis as clinically indicated.
Source: Academic Emergency Medicine - March 2, 2015 Category: Emergency Medicine Authors: Ryan P. Radecki, Arif Azam, Pratik B. Doshi, Rosa C. Banuelos Tags: Original Contribution Source Type: research

Admission Hypomagnesemia Predicts Primary Intracerebral Hemorrhage Volume (P3.093)
CONCLUSIONS: Hypomagnesemia was associated with higher admission ICH volumes in patients with lower ICH severity. While the study was limited by small numbers, a similar relationship between magnesium and ICH volume was not detected amongst patients with more severe ICH. Future studies are needed to determine if correction improves functional outcome in any targeted group of patients with ICH.Disclosure: Dr. Shiue has nothing to disclose. Dr. Boehme has nothing to disclose. Dr. Sands has nothing to disclose. Dr. Martin-Schild has received personal compensation for activities with Genentech as a speakers bureau participant....
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shiue, H., Boehme, A., Sands, K., Martin-Schild, S., Hays Shapshak, A., Lyerly, M., Gadpaille, A., Khawaja, A., Sisson, A., Alvi, M., George, A., Harrigan, M. Tags: Cerebrovascular Disease and Interventional Neurology: Intracerebral Hemorrhage Source Type: research

Abstract 202: Predictors of Percutaneous Endoscopic Gastrostomy in Intracerebral Hemorrhage Session Title: Abstract Poster Session II
Conclusions: We identified several independent early predictors of PEG placement in ICH. Early identification of ICH patients who will require PEG placement could result in reduced resource utilization, quicker initiation of rehabilitation, shorter hospital length of stay, and reduction of preventable complications. Prospective studies are required to determine optimal patient selection and timing for PEG placement.
Source: Circulation: Cardiovascular Quality and Outcomes - February 26, 2016 Category: Cardiology Authors: Blatsioris, A. D., Moser, E. A., Stevenson, A., Carter, R. J., Ofner, S., Hulin, A. L., ONeill, D. P., Cohen-Gadol, A. A., Leipzig, T. J., Williams, L. S., Mackey, J. Tags: Session Title: Abstract Poster Session II Source Type: research

Systemic Thrombolysis, Catheter ‐Directed Thrombolysis and Anticoagulation for Intermediate‐Risk Pulmonary Embolism: A Simulation Modeling Analysis
ConclusionIn our model, for those eligible, CDT results in the largest number of QALYs for patients with intermediate‐risk PE, although it is relatively expensive and the absolute difference in QALYs between anticoagulation alone and CDT is small. Future studies that provide data on longitudinal quality‐of‐life outcomes of patients treated for PE and characteristics of CDT would be beneficial to augment model inputs, inform assumptions, and validate results.This article is protected by copyright. All rights reserved.
Source: Academic Emergency Medicine - June 26, 2017 Category: Emergency Medicine Authors: Christopher Kabrhel, Ayman Ali, Jin Choi, Chin Hur Tags: Original Contribution Source Type: research

Systemic Thrombolysis, Catheter ‐Directed Thrombolysis, and Anticoagulation for Intermediate‐risk Pulmonary Embolism: A Simulation Modeling Analysis
ConclusionIn our model, for those eligible, CDT results in the largest number of QALYs for patients with intermediate‐risk PE, although it is relatively expensive and the absolute difference in QALYs between anticoagulation alone and CDT is small. Future studies that provide data on longitudinal quality‐of‐life outcomes of patients treated for PE and characteristics of CDT would be beneficial to augment model inputs, inform assumptions, and validate results.
Source: Academic Emergency Medicine - September 13, 2017 Category: Emergency Medicine Authors: Christopher Kabrhel, Ayman Ali, Jin G. Choi, Chin Hur Tags: Original Contribution Source Type: research

Impact of Sex on Comparative Outcomes of Radial Versus Femoral Access in Patients With Acute Coronary Syndromes Undergoing Invasive Management: Data From the Randomized MATRIX-Access Trial
Conclusions Women showed a higher risk of severe bleeding and access site complications, and radial access was an effective method to reduce these complications as well as composite ischemic and ischemic or bleeding endpoints.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - January 1, 2018 Category: Cardiology Authors: Gargiulo, G., Ariotti, S., Vranckx, P., Leonardi, S., Frigoli, E., Ciociano, N., Tumscitz, C., Tomassini, F., Calabro, P., Garducci, S., Crimi, G., Ando, G., Ferrario, M., Limbruno, U., Cortese, B., Sganzerla, P., Lupi, A., Russo, F., Garbo, R., Ausiello, Tags: Focus on Cardiovascular Outcomes Among Women Source Type: research

Influence de la leucopathie vasculaire sur l’issue clinique des patients traités par thrombectomie mécanique à la phase aiguë de l’AVC ischémiques : résultats dans l’essai THRACE associé à une cohorte multicentrique
ConclusionOur study provides evidence that patients with AIS due to LVO and severe WMH as assessed by pre-treatment MRI, are at higher risk for less favourable outcome following MT, despite similar rates of sICH and procedural success. Since 27 % of patients with severe WMH in our sample experienced favourable outcome at 3 months, severe WMH burden may not preclude MT.
Source: Journal of Neuroradiology - March 28, 2019 Category: Radiology Source Type: research

Early Prophylactic Hypothermia for Patients With Severe Traumatic Injury: Premature to Close the Case
This study demonstrates that there is no role for the initiation of hypothermia during the acute phase of TBI (1, 2). However, it would be damaging to abandon the concept prematurely. Inflammation Also Paves the Way to Tissue Repair As soon as trauma occurs, the inflammatory cascade begins to take place. The deleterious role of inflammation in the secondary injury response is well-documented, hence the rationale to attempt early prophylactic hypothermia in TBI. However, inflammation also initiates tissue repair and regeneration (3–6). We now know that the secondary injury response accompanies the regenerating and...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Decompressive Craniectomy for Traumatic Brain Injury: Postoperative Cerebral Hemodynamic Evaluation
Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refracto...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Decompressive Craniectomy for Traumatic Brain Injury: Postoperative TCD Cerebral Hemodynamic Evaluation
Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refracto...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Incidence and Risk Factors for Antiplatelet Therapy –Related Bleeding Complications Among Elderly Patients After Coronary Stenting: A Multicenter Retrospective Observation
Conclusion: A higher PRECISE-DAPT score of 33 might be a more reasonable cutoff value for predicting BARC ≥2 type bleeding risk in CAD patients (≥75 years). In addition, the history of hemorrhagic stroke, peptic ulcer, and myocardial infarction were identified as the risk factors of BARC ≥2 type bleeding events.
Source: Frontiers in Pharmacology - July 30, 2021 Category: Drugs & Pharmacology Source Type: research

E-159 Neurointervention on distal MCA occlusions: a multi-center study demonstrating safety and efficacy
ConclusionNeurointervention in distal MCA strokes may be effective. Further prospective, randomized studies in larger cohorts are necessary to compare the efficacy and safety of this technique to other medical treatments of distal MCA strokes.Abstract E-159 Table 1Baseline Characteristics – Summary Statisticsn=228 Baseline ASPECTS 24h ASPECTS Age (mean, sd) 71.46, 14.62 0–5 2 10 Female (%) 115 (50.44%) 6–7 17 15 Location 8 22 13 L M2 122 9 57 22 L M3 21 10 96 13 R M2 81 Baseline NIHSS 24h NIHSS R M3 5 0–4 19 77 Baseline mRS (breakdown) 90 day mRS 5–8 50 28 mRS = 0 132 23 9–12 39 33 mR...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Siddiqui, N., De Leacy, R. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research