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Lifelong cerebrovascular disease burden among CADASIL patients: analysis from a global health research network
DiscussionEarly screening and targeted treatment strategies are warranted to help CADASIL patients with symptom management and risk mitigation.
Source: Frontiers in Neurology - July 14, 2023 Category: Neurology Source Type: research

Characteristics and Outcomes of Children with Cerebral Sinus Venous Thrombosis
ConclusionsCSVT, which has a U-shaped age distribution, is an uncommon condition in children. Stroke is common in children with CSVT, and it is associated with an increased need for mechanical ventilation and increased mortality. The need for mechanical ventilation is more common in infants, and it is associated with increased mortality across all age groups.
Source: Neurocritical Care - July 12, 2023 Category: Neurology Source Type: research

Seasonal variation in the incidence of primary intracerebral hemorrhage: a 16-year nationwide analysis
ConclusionUnlike AIS, ICH incidence is consistently higher in colder quarters, underscoring the need for evaluation and prevention of factors driving seasonal variations in ICH incidence.
Source: Frontiers in Neurology - June 29, 2023 Category: Neurology Source Type: research

Hospital Discharge and Readmissions Before and During the COVID-19 Pandemic for California Acute Stroke Inpatients
Stroke is a leading cause of death and disability in the United States, with approximately 795,000 new strokes occurring annually, including acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH).1 The Coronavirus Disease 2019 (COVID-19) pandemic has impacted all levels of care for stroke patients, such as delays in initial presentation, reduction in acute therapies, limitations of in-patient resources, delays or lack of initiation of secondary stroke prevention therapy, and limitations in rehabilitation services after hospital discharge.
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2023 Category: Neurology Authors: George P. Albert, Daryl C. McHugh, Debra E. Roberts, Adam G. Kelly, Remi Okwechime, Robert G. Holloway, Benjamin P. George Source Type: research

Teleneurocritical Care for Patients with Large Vessel Occlusive Ischemic Stroke Treated by Thrombectomy
ConclusionsTeleneurocritical care allows for equivalent favorable functional outcomes compared with in-person neurocritical care for patients with acute large vessel ischemic stroke receiving thrombectomy. The standardized protocols used by TNCC in this study, specifically the comprehensive 24/7 treatment of patients in the intensive care unit for the length of their stay, may be relevant for other health systems with limited in-person resources; however, additional study is required.
Source: Neurocritical Care - November 2, 2022 Category: Neurology Source Type: research

Annexin A1 upregulates hematoma resolution via the FPR2/p-ERK(1/2)/DUSP1/CD36 signaling pathway after germinal matrix hemorrhage
Exp Neurol. 2022 Oct 21:114257. doi: 10.1016/j.expneurol.2022.114257. Online ahead of print.ABSTRACTGerminal matrix hemorrhage (GMH) is one of the leading causes of morbidity and mortality in preterm infants in the United States, with little progress made in its clinical management. Blood clots disrupting normal cerebrospinal fluid circulation and absorption after germinal matrix hemorrhage are key contributors towards post-hemorrhagic hydrocephalus development. n-formyl peptide receptor 2 (FPR2), a G-protein-coupled receptor, has been associated with the activation of p-ERK1/2, which in turn promotes the transcription of ...
Source: Experimental Neurology - October 24, 2022 Category: Neurology Authors: Jerry J Flores Yan Ding Prativa Sherchan John H Zhang Jiping Tang Source Type: research

Variability in Intensive Care Utilization for Intracerebral Hemorrhage in the United States: Retrospective Cohort Study
We examined whether ICU availability was a significant contributor to ICH outcomes by US geographic region.
Source: Journal of Stroke and Cerebrovascular Diseases - July 1, 2022 Category: Neurology Authors: David Daniel, Daniel Santos, Luke Maillie, Mandip S. Dhamoon Source Type: research

Comparison of Stroke Risk Factors Between Symptomatic and Asymptomatic Patients in a North American Moyamoya Disease Cohort
Conclusions: No significant differences in the prevalence of stroke risk factors between MMD cohorts was found, corroborating evidence provided in a recent Japanese-based study. There were no apparent associations between s troke risk factors and interval cerebrovascular events in an asymptomatic group of MMD patients.
Source: Cerebrovascular Diseases Extra - May 19, 2022 Category: Neurology Source Type: research

An observational epidemiological study to analyze intracerebral hemorrhage across the United States: Incidence and mortality trends from 1990 to 2017
Intracerebral Hemorrhage (ICH) accounts for 10% of strokes annually in the United States (US). Up-to-date trends in disease burden and regional variations remain unknown. Our study reports updated trends of ICH incidence, mortality, and mortality to incidence ratio (MIR) across the US.
Source: Journal of Stroke and Cerebrovascular Diseases - January 25, 2022 Category: Neurology Authors: Augustin J. DeLago, Harpreet Singh, Chinmay Jani, Arashdeep Rupal, Joseph Shalhoub, Richard Goodall, Darshil Shah, Adam Hartley, Matthew Hammond-Haley, Dominic C. Marshall, Martin Gizzi, Mahmood AbdelRazek, Justin D. Salciccioli Source Type: research

Epidemiology of stroke in the last decade: a systematic review
CONCLUSION: There are few studies that analyse the incidence of CVD and even fewer that analyse its evolution. The overall median remains high, although the figures are heterogeneous across studies. Worldwide the trend is towards its decrease, and there are geographical areas, especially in Asia, with an alarming upward trend.PMID:34676530 | DOI:10.33588/rn.7309.2021138
Source: Revista de Neurologia - October 22, 2021 Category: Neurology Authors: F Purroy N Montal à Source Type: research

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