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Condition: Ischemic Stroke
Nutrition: Potassium
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Total 143 results found since Jan 2013.
Novel predictors and a predictive model of cerebrovascular atherosclerotic ischemic stroke based on clinical databases
CONCLUSION: The efficacy of the predictive model was acceptable as an aid in predicting cerebrovascular atherosclerotic ischemic stroke.PMID:36413433 | DOI:10.1080/01616412.2022.2149185
Source: Neurological Research - November 22, 2022 Category: Neurology Authors: He Li Pei Liu Hong-Yu Ma Wei-Long Hua Yong-Xin Zhang Lei Zhang Yong-Wei Zhang Bo Hong Peng-Fei Yang Jian-Min Liu Source Type: research
Severe Hyperkalemia Masquerading as Acute Ischemic Stroke: A Case Report
We report a case of a 63-year-old Caucasian woman, who was admitted to Namazi Hospital, affiliated with Shiraz University of Medical Sciences (Shiraz, Iran) in August 2019. The patient suffered from left-sided weakness and slurred speech for one hour prior to admission. Initially, the patient was treated for acute ischemic stroke, and an intravenous recombinant tissue plasminogen activator (IV-rTPA) was prescribed. However, further investigations showed severe hyperkalemia. Hemiparesis and slurred speech improved significantly with appropriate management of hyperkalemia. To the best of our knowledge, this is the first case...
Source: Atherosclerosis - November 16, 2022 Category: Cardiology Authors: Zahra Bahrami Marzieh Salimi Vahid Reza Ostovan Source Type: research
Reinventing the Penumbra - the Emerging Clockwork of a Multi-modal Mechanistic Paradigm
Transl Stroke Res. 2022 Oct 11. doi: 10.1007/s12975-022-01090-9. Online ahead of print.ABSTRACTThe concept of the ischemic penumbra was originally defined as the area around a necrotic stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra is generally considered as time-sensitive hypoperfused brain tissue with decreased oxygen and glucose availability, salvageable tissue as treated by intervention, and the potential target for neuroprotection in focal stroke. The original concept entailed electrical failure and potassium release but one short of neuronal cell death and was based on expe...
Source: Cell Research - October 11, 2022 Category: Cytology Authors: Jakob Walther Elena Marie Kirsch Lina Hellwig Sarah S Schmerbeck Paul M Holloway Alastair M Buchan Philipp Mergenthaler Source Type: research
Reinventing the Penumbra — the Emerging Clockwork of a Multi-modal Mechanistic Paradigm
AbstractThe concept of the ischemic penumbra was originally defined as the area around a necrotic stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra is generally considered as time-sensitive hypoperfused brain tissue with decreased oxygen and glucose availability, salvageable tissue as treated by intervention, and the potential target for neuroprotection in focal stroke. The original concept entailed electrical failure and potassium release but one short of neuronal cell death and was based on experimental stroke models, later confirmed in clinical imaging studies. However, even thou...
Source: Translational Stroke Research - October 11, 2022 Category: Neurology Source Type: research
LncRNA KCNQ1OT1 predicts further cerebral events in patients with transient ischemic attack
Transient ischemic attack (TIA) poses a great threat of cerebrovascular diseases to a large number of patients, despite its reversible neurological dysfunction. Long non-coding RNAs (lncRNAs) have been proven to play critical roles in the pathophysiological development of cerebrovascular events. Exploring the function of lncRNAs in modulating TIA prognosis would help to develop individualized therapeutics. A total of 231 participants with the first onset of TIA were recruited in the study, including 65 subsequent stroke patients. The expression of lncRNA potassium voltage-gated channel subfamily Q member 1 opposite strand ...
Source: Frontiers in Pharmacology - October 7, 2022 Category: Drugs & Pharmacology Source Type: research
Highly efficient radiosynthesis and biological evaluation of 18Fsafinamide, a radiolabelled anti-parkinsonian drug for PET imaging
ChemMedChem. 2022 Sep 6. doi: 10.1002/cmdc.202200472. Online ahead of print.ABSTRACTAs an add-on drug approved for Parkinson's disease treatment, safinamide has multiple functions, such as selective and reversible monoamine oxidase-B inhibition, voltage-sensitive sodium/potassium channel blockage, and glutamate release inhibition. Meanwhile, safinamide shows tremendous therapeutic potential in the context of other central nervous system diseases (e.g., ischaemic stroke, amyotrophic lateral sclerosis, depression, etc.). In this work, [18F]safinamide, which is safinamide labelled by the positron-emitting radionuclide [18F]fl...
Source: ChemMedChem - September 7, 2022 Category: Chemistry Authors: Yangyang Xu Peili Cen Lijuan Ma Mei Tian Xue Zhang Qinghua Zhang Kaiwu Yu Hong Zhang Wangjun Gu Qinggang He Source Type: research
Bergapten attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting Kv1.3 and Carbonyl reductase 1
Eur J Pharmacol. 2022 Sep 1:175242. doi: 10.1016/j.ejphar.2022.175242. Online ahead of print.ABSTRACTMicroglia-mediated neuroinflammation plays a vital role in the pathogenesis of ischemic stroke, which serves as a prime target for developing novel therapeutic agent. However, feasible and effective agents for controlling neuroinflammation are scarce. Bergapten were acknowledged to hold therapeutic potential in restricting inflammation in multiple diseases, including peripheral neuropathy, migraine headaches and osteoarthritis. Here, we aimed to investigate the impact of bergapten on microglia-mediated neuroinflammation and...
Source: European Journal of Pharmacology - September 4, 2022 Category: Drugs & Pharmacology Authors: Shenghan Gao Xinxin Zou Zibu Wang Xin Shu Xiang Cao Shengnan Xia Pengfei Shao Xinyu Bao Haiyan Yang Yun Xu Pinyi Liu Source Type: research
Clinical Characteristics of Patients with Arrhythmias of the Idiopathic Outflow Tract Ventricular: Age, Gender, Comorbidities, Laboratory Test Results, and Echocardiographic Parameters
CONCLUSIONS: The outflow tract served as the major original site of IVAs, and significant differences existed between participants in the LVOT and RVOT groups in age; gender; comorbidities; results of laboratory examinations, including red-blood-cell counts, hemoglobin, creatinine, and GGT; and echocardiographic parameters, including LVEF%, LAD, LVEDD, IVS, and LVPWT.PMID:35687704
Source: Alternative Therapies in Health and Medicine - June 10, 2022 Category: Complementary Medicine Authors: Lei Zhao Ruibin Li Jidong Zhang Ruiqin Xie Jingchao Lu Jinming Liu Chenglong Miao Suyun Liu Wei Cui Source Type: research
