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Condition: Ischemic Stroke
Nutrition: Chloride

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Total 375 results found since Jan 2013.

Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway
CONCLUSION: Rhein attenuates cerebral I/R injury by inhibiting ferroptosis via the NRF2/SLC7A11/GPX4 axis, highlighting its potential as a therapeutic agent for ischemic stroke.PMID:37714424 | DOI:10.1016/j.expneurol.2023.114541
Source: Experimental Neurology - September 15, 2023 Category: Neurology Authors: Hua Liu Tian-Ai Zhang Wen-Yue Zhang Si-Rui Huang Yue Hu Jia Sun Source Type: research

Identification of Novel Circular RNA Targets in Key Penumbra Region of Rats After Cerebral Ischemia-Reperfusion Injury
AbstractCircular RNAs (circRNAs) are abundantly and stably expressed in the brain of mammals and humans. Some circRNAs are implicated in ischemic stroke. Therefore, we aimed to detect how circRNAs change in the key penumbra area during cerebral ischemia-reperfusion (CI/R) injury. Rats were subjected to transient middle cerebral artery occlusion (tMCAO), during which the permanent blocking period was 2 h and reperfusion time was 24 or 72 h. Then modified neurologic severity score (mNSS), triphenyl tetrazolium chloride (TTC) staining and HE staining were used to exhibiting damage between rats in different groups. The penumbr...
Source: Journal of Molecular Neuroscience - September 9, 2023 Category: Neuroscience Source Type: research

SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
In this study, electrophysiological properties of chloride current in primary cultured neurons were characterized using low chloride solution, 4,4 ′-diisothiocyano-2,2′-stilbenedisulfonic acid, and SLC26A11-specific siRNA under physiological conditions or ATP-depleted conditions. In vivo effect of SLC26A11 was evaluated on a rat stroke reperfusion model. We found that SLC26A11 mRNA in primary cultured neurons was upregulated as early as 6  h after oxygen glucose deprivation, and later, the protein level was elevated accordingly. Blockade of SLC26A11 activity could reduce chloride entry and attenuate hypoxia-induced ne...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research

Recent advances in the structure and activation mechanisms of metabolite-releasing Pannexin 1 channels
Biochem Soc Trans. 2023 Aug 25:BST20230038. doi: 10.1042/BST20230038. Online ahead of print.ABSTRACTPannexin 1 (PANX1) is a widely expressed large-pore ion channel located in the plasma membrane of almost all vertebrate cells. It possesses a unique ability to act as a conduit for both inorganic ions (e.g. potassium or chloride) and bioactive metabolites (e.g. ATP or glutamate), thereby activating varying signaling pathways in an autocrine or paracrine manner. Given its crucial role in cell-cell interactions, the activity of PANX1 has been implicated in maintaining homeostasis of cardiovascular, immune, and nervous systems....
Source: Biochemical Society Transactions - August 25, 2023 Category: Biochemistry Authors: Yi-Ling Wu Ai-Hsing Yang Yu-Hsin Chiu Source Type: research

Dihydromyricetin Alleviates Ischemic Brain Injury by Antagonizing Pyroptosis in Rats
AbstractIschemic stroke is a worldwide disease that seriously threatens human health, and there are few effective drugs to treat it. Dihydromyricetin (DHM) has anti-inflammatory, antioxidant, and antiapoptotic functions. We identified pyroptosis following ischemic stroke. Here, we investigated the effect of DHM on ischemic stroke and pyroptosis. In the first part of the experiment, Sprague-Dawley rats were randomly divided into the sham group and MCAO group. The MCAO model was established by occlusion of the middle cerebral artery for 90  min using a silica gel suture. The ischemic penumbra was used for mRNA sequencing 1Â...
Source: Neurotherapeutics - August 21, 2023 Category: Neurology Source Type: research

Overexpression of Circ_0005585 Alleviates Cerebral Ischemia Reperfusion Injury via Targeting MiR-16-5p
Circular RNAs are implicated in the pathogenesis of ischemic stroke. In this work, we explored the modulation and potential mechanisms of action of circ_0005585 in ischemic stroke. Expression of circ_0005585 and miR-16-5p was assessed by quantitative real-time reverse transcription PCR. Ischemic stroke was modeled in mice by middle cerebral artery occlusion (MCAO). The infarct volume was assessed by triphenyl tetrazolium chloride staining. Neurological deficits were evaluated according to Neurological Severity Score. The permeability of the blood —brain barrier was assessed by Evan’s blue leakage and brain water conten...
Source: Bulletin of Experimental Biology and Medicine - August 11, 2023 Category: Biology Source Type: research

LncRNA < em > PCBP1-AS1 < /em > Induces Cerebral Ischemia/Reperfusion Injury via the < em > miR-506-3p/CCL2 < /em > Axis
CONCLUSION: LncRNA PCBP1-AS1 sequesters miR-506-3p to upregulate CCL2 expression, thereby aggravating I/R injury, suggesting its potential for RNA-targeted treatment of cerebral ischemic stroke.PMID:37437927
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Zhili He Ling Chen Wei Zhang Source Type: research