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Condition: Ischemic Stroke
Nutrition: Antidoxidants
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Total 671 results found since Jan 2013.
Sphingosine 1-phosphate and its regulatory role in vascular endothelial cells
We presently review the levels of S1P in those vascular and vascular-related diseases. Plasma S1P levels were reduced in various inflammation-related diseases such as atherosclerosis and sepsis, but were increased in other diseases including type 2 diabetes, neurodegeneration, cerebrovascular damages such as acute ischemic stroke, Alzheimer's disease, vascular dementia, angina, heart failure, idiopathic pulmonary fibrosis, community-acquired pneumonia, and hepatocellular carcinoma. Then, we highlighted the molecular mechanism by which S1P regulated EC biology including vascular development and angiogenesis, inflammation, p...
Source: Atherosclerosis - February 4, 2022 Category: Cardiology Authors: Yan Qiu Junyi Shen Wenli Jiang Yi Yang Xiaoheng Liu Ye Zeng Source Type: research
Molecules, Vol. 27, Pages 1049: Coffee-Derived Phenolic Compounds Activate Nrf2 Antioxidant Pathway in I/R Injury In Vitro Model: A Nutritional Approach Preventing Age Related-Damages
essandra Bulbarelli
Age-related injuries are often connected to alterations in redox homeostasis. The imbalance between free radical oxygen species and endogenous antioxidants defenses could be associated with a growing risk of transient ischemic attack and stroke. In this context, a daily supply of dietary antioxidants could counteract oxidative stress occurring during ischemia/reperfusion injury (I/R), preventing brain damage. Here we investigated the potential antioxidant properties of coffee-derived circulating metabolites and a coffee pulp phytoextract, testing their efficacy as ROS scavengers in an in vitro model...
Source: Molecules - February 3, 2022 Category: Chemistry Authors: Elena Lonati Tatiana Carrozzini Ilaria Bruni Pedro Mena Laura Botto Emanuela Cazzaniga Daniele Del Rio Massimo Labra Paola Palestini Alessandra Bulbarelli Tags: Article Source Type: research
Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPAR δ for antioxidant action
Free Radic Biol Med. 2022 Jan 27:S0891-5849(22)00033-8. doi: 10.1016/j.freeradbiomed.2022.01.022. Online ahead of print.ABSTRACTCerebral ischemic stroke ranks the second leading cause of death and the third leading cause of disability in lifetime all around the world, urgently necessitating effective therapeutic interventions. Reactive oxygen species (ROS) have been implicated in stroke pathogenesis and peroxisome proliferator-activated receptors (PPARs) are prominent targets for ROS management. Although recent research has shown antioxidant effect of berberine (BBR), little is known regarding its effect upon ROS-PPARs sig...
Source: Free Radical Biology and Medicine - January 30, 2022 Category: Biology Authors: Jia-Wen Shou Xiao-Xiao Li Yun-Sang Tang Bobby Lim-Ho Kong Hoi-Yan Wu Meng-Jie Xiao Chun-Kai Cheung Pang-Chui Shaw Source Type: research
Dihydromyricetin ameliorates oxygen ‑glucose deprivation and re‑oxygenation‑induced injury in HT22 cells by activating the Wnt/β‑catenin signaling pathway
In conclusion, DMY protected HT22 cells from OGD/R‑induced oxidative stress and apoptosis, and its effects may be mediated by the activation of the Wnt/β‑catenin signaling pathway.PMID:35088876 | DOI:10.3892/mmr.2022.12619
Source: Molecular Medicine Reports - January 28, 2022 Category: Molecular Biology Authors: Xiaoxiao Tao Yaping Jiang Xian Zheng Xiaoxiao Ji Feifei Peng Source Type: research
Antioxidant and Anti-apoptotic Effects of Cannabidiol in Model of Ischemic Stroke in Rats
Brain Res Bull. 2022 Jan 11:S0361-9230(22)00004-1. doi: 10.1016/j.brainresbull.2022.01.001. Online ahead of print.ABSTRACTOne of the main non-psychoactive phytocannabinoids of cannabis is cannabidiol (CBD), which has attracted much attention for its neuroprotective roles. The present study was designed to assess whether pretreatment of CBD can attenuate two of the destructive processes of cerebral ischemia, including oxidative stress and cell death. The male rats were randomly divided into 6 main groups (control, MCAO, vehicle, and CBD-treated groups). Using stereotaxic surgery, a cannula was inserted into the right latera...
Source: Brain Research - January 15, 2022 Category: Neurology Authors: Sepideh Khaksar Mohammadreza Bigdeli Arash Samiee Zahra Shirazi-Zand Source Type: research
