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Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke
This study aimed to determine all-cause in-hospital mortality, medication-related hypotensive episodes, development of hospital acquired infections and hospital length of stay between nicardipine and labetalol use for the management of hypertension after acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2019 Category: Neurology Authors: Mahsa Sadeghi, Hamidreza Saber, Azara Singh, Claudia Hanni, Dennis Parker, Aaron Desai, Wazim Mohamed Source Type: research

Machine Learning Techniques in Blood Pressure Management During the Acute Phase of Ischemic Stroke
ConclusionThis is the first study to address BP management in the acute phase of ischemic stroke using ML techniques. The results indicate that the treatment choice should be adjusted to different clinical and BP parameters, thus, providing a better decision-making approach.
Source: Frontiers in Neurology - February 14, 2022 Category: Neurology Source Type: research

Stroke Units with Dedicated Bedside Monitoring Improves Blood Pressure Control (P6.265)
Conclusions:Patients monitored on dedicated stroke units can obtain control of their blood pressure with adequate adjustment of oral medications and require fewer acute IV labetalol treatments than patients who are not being continuously monitored. Prevention of sudden elevations in BP may translate into lower rates of hemorrhagic transformation or hematoma expansion in stroke patients and confer to a better clinical outcome.Disclosure: Dr. Z Arango has nothing to disclose. Dr. Suhan has nothing to disclose. Dr. Song has nothing to disclose. Dr. DeCarvalho has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Kul...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Arango, A., Suhan, L., Song, Y.-B., DeCarvalho, B., Mehta, S., Kulhari, A., Panezai, S., Kirmani, J. F. Tags: Cerebrovascular Disease Systems of Care and Health Policy Source Type: research

Regional Differences in Early BP Management After Acute Ischemic Stroke in the ENCHANTED International Randomized Controlled Trials
Conclusion: Regional variations in early BP management in acute stroke translated into differences in early BP control parameters.
Source: Frontiers in Neurology - August 27, 2021 Category: Neurology Source Type: research

Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine
Conclusions: Adequate initial dosing of antihypertensive treatment has the potential to reduce time to blood pressure control and possibly time to alteplase therapy. The optimal antihypertensive regimen for controlling blood pressure before alteplase therapy remains unclear.
Source: Journal of Neuroscience Nursing - November 5, 2015 Category: Neuroscience Tags: Pharmacology Update Source Type: research

Abstract 232: Parenteral Antihypertensive Use on the First Day of Hospitalization after Acute Ischemic Stroke: A US Population Study Poster Session II
Conclusion: Approximately 16% of AIS patients receive IV AH medication in the first 24 hours of admission in the US. The rate of early AH treatment has increased over time both overall and among those who did not receive rt-PA. Whether this is due to increasingly aggressive BP treatment by physicians or higher BP on admission among AIS patients is unclear. Contrary to recommendations, nicardipine was used infrequently. More evidence is required to justify specific AH agents for BP treatment in AIS.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Wang, Y., McDonough, E., Adeoye, O., LaPensee, K., Crothers, T. C., Kleindorfer, D. Tags: Poster Session II Source Type: research

Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients
Conclusion: This randomized study will provide important information about the physiological effects of BP reduction on cerebral perfusion after intravenous thrombolysis in AIS.
Source: Medicine - October 1, 2018 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Debilitating Headache after an Excited Reaction
​BY GREGORY TAYLOR, DO, & MATTHEW WARPINSKI, DOA 35-year-old man with a history of uncontrolled hypertension and medical noncompliance was brought to the emergency department by EMS complaining of a headache. The family said the patient was watching football and developed an acute headache after he stood up screaming in excitement.His family said he had not taken his blood pressure medication for years. He was afebrile, his blood pressure was 245/129 mm Hg, his respiratory rate was 18 bpm, his heart rate was 68 bpm, and he weighed 340 pounds. The patient was obtunded with a Glasgow Coma Scale score of 4 and was subse...
Source: The Case Files - November 20, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

O60. Treatment of hypertension in pregnancy
Conclusions According to recent guidelines, in the absence of randomised clinical trials recommendations how hypertension should be treated in pregnant women, can only be guided by experts’ opinion based on case reports and their meta-analyses.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - August 31, 2015 Category: OBGYN Source Type: research

Focused Update on Pharmacologic Management of Hypertensive Emergencies
AbstractPurpose of ReviewHypertensive emergency is defined as a systolic blood pressure>  180 mmHg or a diastolic blood pressure>  120 mmHg with evidence of new or progressive end-organ damage. The purpose of this paper is to review advances in the treatment of hypertensive emergencies within the last 5 years.Recent FindingsNew literature and recommendations for managing hypertensive emergencies in the setting of pregnancy, stroke, and heart failure have been published.SummaryOral nifedipine is now considered an alternative first-line therapy, along with intravenous hydralazine and labetalol for women presenti...
Source: Current Hypertension Reports - June 8, 2018 Category: Primary Care Source Type: research

Bilateral carotid artery dissection in a severe preeclamptic setting: An unusual cause of postpartum headache.
Abstract A 30-year-old woman with severe preeclampsia presented at 27weeks of amenorrhea with left headache, neck pain, blurred vision and numbness of left hemiface that resolved spontaneously within 2hours. A week later, hypertension remained poorly controlled despite combination of nicardipine and labetalol intravenous therapy; an urgent caesarean section was eventually performed due to onset of HELLP syndrome. At day 5 postpartum, the patient had a Horner syndrome with right ipsilateral disabling tinnitus. A CT-angiography of supra-aortic trunks was performed urgently; it showed a bilateral carotid arterial dis...
Source: Annales Francaises d'Anesthesie et de Reanimation - April 1, 2013 Category: Anesthesiology Authors: Hoffmann C, Augé M, Falzone E, Martel-Jacob S, Mercier FJ Tags: Ann Fr Anesth Reanim Source Type: research