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Condition: Ischemic Stroke
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Total 193 results found since Jan 2013.
MiR-499a prevents astrocytes mediated inflammation in ischemic stroke by targeting PTEN
CONCLUSIONS: Taken together, our findings indicate miR-499a as an important factor to prevent inflammatory response and suggest miR-499a as a new molecule for the treatment of IS. The present study also demonstrated the relationship between miR-499a and PTEN, with PTEN as a downstream signaling mediator of miR-499a in the inflammatory response of astrocytes induced by IS.PMID:34632168 | PMC:PMC8488463 | DOI:10.1016/j.ncrna.2021.09.002
Source: Cell Research - October 11, 2021 Category: Cytology Authors: Xiaoxiang Guan Yiwei Zhang Ilgiz Gareev Ozal Beylerli Xinyuan Li Guitian Lu Lin Lv Xin Hai Source Type: research
Silent information regulator 1 ameliorates oxidative stress injury via PGC-1 α/PPARγ-Nrf2 pathway after ischemic stroke in rat
CONCLUSION: Overall, our data indicated that SIRT1 directly mediated the PGC-1α/PPARγ pathway in response to focal cerebral ischemia/reperfusion-induced neurological deficit, providing insights into the treatment of focal cerebral ischemia/reperfusion injury.PMID:34774993 | DOI:10.1016/j.brainresbull.2021.11.001
Source: Brain Research Bulletin - November 14, 2021 Category: Neurology Authors: Yang Zhou Li Peng Yixin Li Yong Zhao Source Type: research
Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPAR δ for antioxidant action
Free Radic Biol Med. 2022 Jan 27:S0891-5849(22)00033-8. doi: 10.1016/j.freeradbiomed.2022.01.022. Online ahead of print.ABSTRACTCerebral ischemic stroke ranks the second leading cause of death and the third leading cause of disability in lifetime all around the world, urgently necessitating effective therapeutic interventions. Reactive oxygen species (ROS) have been implicated in stroke pathogenesis and peroxisome proliferator-activated receptors (PPARs) are prominent targets for ROS management. Although recent research has shown antioxidant effect of berberine (BBR), little is known regarding its effect upon ROS-PPARs sig...
Source: Free Radical Biology and Medicine - January 30, 2022 Category: Biology Authors: Jia-Wen Shou Xiao-Xiao Li Yun-Sang Tang Bobby Lim-Ho Kong Hoi-Yan Wu Meng-Jie Xiao Chun-Kai Cheung Pang-Chui Shaw Source Type: research
Isoflurane and Netrin-1 combination therapy enhances angiogenesis and neurological recovery by improving the expression of HIF-1 α-Netrin-1-UNC5B/VEGF cascade to attenuate cerebral ischemia injury
In conclusion, our results suggested that ISO combined with NT-1 could promote angiogenesis, recover long-term neurobehavioral function, and attenuate cerebral ischemia injury by activating the HIF-1α-Netrin-1-UNC5B/VEGF cascade.PMID:35247371 | DOI:10.1016/j.expneurol.2022.114028
Source: Experimental Neurology - March 5, 2022 Category: Neurology Authors: Nian Li Xu Zhang Jingwen Zhai Jiangwen Yin Ketao Ma Ruixue Wang Xinlei Qin Yan Li Xiwei Dong Sheng Wang Source Type: research
DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction
Eur J Pharm Sci. 2022 Mar 5:106164. doi: 10.1016/j.ejps.2022.106164. Online ahead of print.ABSTRACTAtherosclerosis is the common pathophysiological foundation of ischaemic stroke and myocardial ischaemia. Oxidative stress is intricately related to the progress of atherosclerosis. DL-3-n-butylphthalide (NBP) is a synthesized raceme of L-3-n-butylphthalide that is first isolated from celery. As a neuroprotective agent, NBP also exhibits potent antioxidative activity. Our research aimed to evaluate the effect of NBP on atherosclerosis and to explore the underlying antioxidative mechanisms and targets. Firstly, we detected the...
Source: Atherosclerosis - March 8, 2022 Category: Cardiology Authors: Jibo Han Xiaowen Shi Jiajun Xu Wante Lin Yanghao Chen Bingjiang Han Yi Wang Jianjiang Xu Source Type: research
Isoflurane and Netrin-1 combination therapy enhances angiogenesis and neurological recovery by improving the expression of HIF-1 α-Netrin-1-UNC5B/VEGF cascade to attenuate cerebral ischemia injury
In conclusion, our results suggested that ISO combined with NT-1 could promote angiogenesis, recover long-term neurobehavioral function, and attenuate cerebral ischemia injury by activating the HIF-1α-Netrin-1-UNC5B/VEGF cascade.PMID:35247371 | DOI:10.1016/j.expneurol.2022.114028
Source: Experimental Neurology - March 5, 2022 Category: Neurology Authors: Nian Li Xu Zhang Jingwen Zhai Jiangwen Yin Ketao Ma Ruixue Wang Xinlei Qin Yan Li Xiwei Dong Sheng Wang Source Type: research
