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Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt
Conclusion
We have shown that SCD subjects are much more likely than non-SCD subjects to have impaired cardiac, but intact peripheral responses to orthostatic stress induced by HUT. These abnormal responses are associated with low baseline cardiac parasympathetic activity, independent of hemoglobin level. The classification of autonomic phenotypes based on HUT response may have potential use for predicting disease severity, guiding and targeting treatments/interventions to alleviate the risk of adverse outcomes in SCD.
Ethics Statement
All experiments were conducted at Children’s Hospital Los Angeles (CHLA). The ...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research
5 Scary Symptoms That Are Usually Harmless
SPECIAL FROM Next Avenue
By Linda Melone
After 50, aches, pains and the occasional muscle twinge become a fact of life. But some symptoms that may seem frightening or serious turn out to be far less than they appear.
While you should always see a doctor if you experience something out of the ordinary, these signs generally are more smoke than fire:
A Bloody Nose
Nosebleeds can be particularly frightening due to the suddenness in which they occur and the sometimes large amount of blood involved.
“People worry that it’s internal bleeding, but almost every time it’s not,” says Dr. Carlo Reyes, emergency room...
Source: Healthy Living - The Huffington Post - February 5, 2015 Category: Consumer Health News Source Type: news
Freedom in waiting: A ventricular assist device gives Aidan’s family independence
Aidan
When Aidan was just 8 months old, his parents Patrick and Tavina received shocking news—their son had hypertrophic cardiomyopathy, a rare but serious disease that affects the muscle of the heart. Given his young age and severity of his condition, the early prognosis was bleak.
“Things didn’t look good at first,” remembers Patrick. “We were steeling ourselves for the real possibility that Aidan wouldn’t make it to see his first birthday.”
But, heart condition or not, little Aidan was a fighter, and with minimal medical management his condition stabilized. Over the years, he grew ...
Source: Thrive, Children's Hospital Boston - July 3, 2013 Category: Pediatrics Authors: Tripp Underwood Tags: All posts Heart conditions Our patients’ stories Christina VanderPluym Heart Center heart transplant hypertrophic cardiomyopathy MD VAD ventricular assist device Source Type: news
Prognostic factors for mortality, intensive care unit and hospital admission due to SARS-CoV-2: a systematic review and meta-analysis of cohort studies in Europe
Background
As mortality from coronavirus disease 2019 (COVID-19) is strongly age-dependent, we aimed to identify population subgroups at an elevated risk for adverse outcomes from COVID-19 using age-/gender-adjusted data from European cohort studies with the aim to identify populations that could potentially benefit from booster vaccinations.
Methods
We performed a systematic literature review and meta-analysis to investigate the role of underlying medical conditions as prognostic factors for adverse outcomes due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including death, hospitalisation, intensive c...
Source: European Respiratory Review - November 2, 2022 Category: Respiratory Medicine Authors: Vardavas, C. I., Mathioudakis, A. G., Nikitara, K., Stamatelopoulos, K., Georgiopoulos, G., Phalkey, R., Leonardi-Bee, J., Fernandez, E., Carnicer-Pont, D., Vestbo, J., Semenza, J. C., Deogan, C., Suk, J. E., Kramarz, P., Lamb, F., Penttinen, P. Tags: Respiratory infections and tuberculosis Reviews Source Type: research
How AI Is Changing Medical Imaging to Improve Patient Care
That doctors can peer into the human body without making a single incision once seemed like a miraculous concept. But medical imaging in radiology has come a long way, and the latest artificial intelligence (AI)-driven techniques are going much further: exploiting the massive computing abilities of AI and machine learning to mine body scans for differences that even the human eye can miss.
Imaging in medicine now involves sophisticated ways of analyzing every data point to distinguish disease from health and signal from noise. If the first few decades of radiology were about refining the resolution of the pictures taken of...
Source: TIME: Health - November 4, 2022 Category: Consumer Health News Authors: Alice Park and Video by Andrew D. Johnson Tags: Uncategorized Frontiers of Medicine 2022 healthscienceclimate Innovation sponsorshipblock Source Type: news
A Sugar Replacement May Be Linked to Heart Attacks and Strokes. Don ’ t Throw Out Your Stash Yet
Sugar replacements are everywhere in foods and beverages. But despite their ubiquity, the scientific verdict on whether or not they pose health risks ping pongs back and forth. Every so often, though, a study is published with a conclusion so shocking that it forces people to reassess their pantries. A Feb. 27 study published in the journal Nature Medicine now seems to have dealt such a blow to the sweetener erythritol, with data that suggest a connection between the ingredient and cardiovascular events such as clotting, stroke, and heart attacks.
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But before you clear your shel...
Source: TIME: Health - March 3, 2023 Category: Consumer Health News Authors: Haley Weiss Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news
PET scans may improve brain injury diagnosis
ConclusionThis is a valuable diagnostic study that tested how accurate PET and fMRI imaging are at distinguishing between different levels of conscious state and helping to predict recovery. Diagnostic assessments are traditionally made using bedside clinical tests – but as the researchers say, judging the level of awareness in people with severe brain damage can be difficult.In particular, the researchers wanted to see whether the scans could accurately distinguish between people with “unresponsive wakefulness syndrome” and “minimally conscious state”, as distinguishing between these two states can have impor...
Source: NHS News Feed - April 16, 2014 Category: Consumer Health News Tags: Medical practice Neurology Source Type: news
French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research
Will Too Much Sleep Make You Fat?
In last week's article, you learned exactly how not getting enough sleep (less than about 7 hours per night), can cause fat gain, muscle loss and an inability to control the appetite, along with increased risk for a host of chronic diseases such as diabetes and obesity.
But the solution is definitely not to begin sleeping as much as you possibly can. Oversleeping may seem like a good idea to fight off the fat gain that can accompany undersleeping, but it's been shown that sleeping in excess of 9 hours per night can be just as damaging to your sleep cycles and your waistline as not getting enough sleep, and in this article...
Source: Healthy Living - The Huffington Post - August 5, 2016 Category: Consumer Health News Source Type: news
Cochrane Priority Reviews List: December 2016 Update
Cochrane-wide prioritisation remains an important project, with over 140 priority reviews or updates have been published since it began in January 2015.The December 2016 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Airways, Anaesthesia, Dementia& Cognitive Improvement, ENT, Epilepsy, Gynaecological, Neuro-oncology and Orphan Cancers, Gynaecology& Fertility, Haematological Malignancies, Heart, Incontinence, Kidney& Transplant, Lung Cancer, Neuromuscular Disease, Oral Health, Skin, Stroke, and Urology Groups.The following titles on the list are open to new authors:Long-acti...
Source: Cochrane News and Events - December 14, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news
How to Boost Your Stem Cells
A California man named Kris Boesen was completely paralyzed after breaking his neck in a terrible car crash last March. But now he can brush his teeth and hug his family again…
He's even started to regain sensation in his legs.
And it's all because of a simple procedure he underwent about a month after his accident: stem cell therapy.
During Kris' procedure, researchers at the University of Southern California injected 10 million stem cells into his spinal cord.
Within two weeks, he could wiggle his fingers. Three months later, he was able to feed himself, write his name and operate his wheelchair.
His re...
Source: Al Sears, MD Natural Remedies - March 23, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news
HealthWatch: How Sweeteners And Sleep Influence Weight Gain
BOSTON (CBS) – A new report shows inadequate sleep could be making you fat.
Researchers in the United Kingdom found that adults who slept an average of 6 hours a night weighed more and had a waist circumference about an inch larger than those getting 9 hours of sleep a night.
They also had lower levels of HDL or “good” cholesterol.
While most of us do not get 9 hours of sleep a night, we should all strive to get at least 7 to 8.
That’s because there is growing evidence that chronic sleep deprivation can increase our risk of obesity and metabolic disorders like diabetes and high cholesterol, which can lead to...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - August 2, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News artificial sweeteners Dr. Mallika Marshall Health Watch Weight Loss Source Type: news
AI and Health Care Are Made for Each Other
Artificial intelligence has the potential to radically change health care. Imagine a not too distant future when the focus shifts away from disease to how we stay healthy.
At birth, everyone would get a thorough, multifaceted baseline profile, including screening for genetic and rare diseases. Then, over their lifetimes, cost-effective, minimally invasive clinical-grade devices could accurately monitor a range of biometrics such as heart rate, blood pressure, temperature and glucose levels, in addition to environmental factors such as exposure to pathogens and toxins, and behavioral factors like sleep and activity patterns...
Source: TIME: Health - October 24, 2019 Category: Consumer Health News Authors: Geralyn Miller Tags: Uncategorized Healthcare Source Type: news
