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Condition: Epilepsy
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Total 1483 results found since Jan 2013.
Frequency and predictors of poststroke epilepsy after mechanical thrombectomy for large vessel occlusion stroke: results from a multicenter cohort study
ConclusionIn our study, patients with large vessel occlusion stroke receiving MT had a 9% prevalence of PSE over a median follow-up period of 6.5 years. Besides larger infarct size, presence of cerebral microbleeds on brain MRI predicted PSE occurrence.
Source: Journal of Neurology - September 2, 2023 Category: Neurology Source Type: research
Flexible, Miniaturized Sensing Probes Inspired by Biofuel Cells for Monitoring Synaptically Released Glutamate in the Mouse Brain
Angew Chem Int Ed Engl. 2023 Aug 26:e202310245. doi: 10.1002/anie.202310245. Online ahead of print.ABSTRACTChemical biomarkers in the central nervous system can provide valuable quantitative measures to gain insight into the etiology and pathogenesis of neurological diseases. Glutamate, one of the most important excitatory neurotransmitters in the brain, has been found to be upregulated in various neurological disorders, such as traumatic brain injury, Alzheimer's disease, stroke, epilepsy, chronic pain, and migraines. However, quantitatively monitoring glutamate release in situ has been challenging. This work presents a n...
Source: Angewandte Chemie - August 26, 2023 Category: Chemistry Authors: Prasad Nithianandam Tzu-Li Liu Shulin Chen Yizhen Jia Yan Dong Morgan Saul Andrea Tedeschi Wenjing Sun Jinghua Li Source Type: research
Watch a person unable to speak for years ‘talk’ using a new brain implant
When it comes to talking, our brain does the heavy lifting. It subconsciously directs the complex coordination of lips, tongue, throat, and jaws we need to pronounce words. And it keeps directing, even in people with paralysis or who are unable to turn these commands into speech.
Now, scientists have harnessed this phenomenon to create brain implants that transform this neural activity into text with unprecedented speed and accuracy. In two new studies—both reported today in
Nature
—the devices enabled two people to “speak” for the first time in more than a decade. The implants produced speech from brain...
Source: ScienceNOW - August 23, 2023 Category: Science Source Type: news
Association of Plasma A β 42/40 Ratio and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study
DISCUSSION: A reduction in plasma Aβ42/Aβ40 is associated with an increased risk of subsequent epilepsy. Our observations provide a further validation of the link between Aβ, hyperexcitable states, and LOE.PMID:37541842 | DOI:10.1212/WNL.0000000000207635
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Emily L Johnson Kevin J Sullivan Andrea Lauren Christman Schneider Jeannette Simino Tom H Mosley Anna Kucharska-Newton David S Knopman Rebecca F Gottesman Source Type: research
Trends in volume-regulated anion channel (VRAC) research: visualization and bibliometric analysis from 2014 to 2022
Conclusion: The aim of this bibliometric analysis is to provide an overall perspective for research on VRAC. VRAC has become a topic of increasing interest, and our analysis shows that it continues to be a prominent area. This study offers insights into the investigation of VRAC channel and may guide researchers in identifying new directions for future research.PMID:37538172 | PMC:PMC10394876 | DOI:10.3389/fphar.2023.1234885
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Tianbao Liu Yin Li Dawei Wang Tobias Stauber Jiajun Zhao Source Type: research
Molecules, Vol. 28, Pages 5824: Neurological Applications of Celery (Apium graveolens): A Scoping Review
In conclusion, the safety of A. graveolens extract and NBP can be further investigated clinically on different neurological disorders based on their potential role in different targeted pathways.
Source: Molecules - August 2, 2023 Category: Chemistry Authors: Terence Yew Chin Tan Xin Yi Lim Nor Azrina Norahmad Hemahwathy Chanthira Kumar Bee Ping Teh Nai Ming Lai Ami Fazlin Syed Mohamed Tags: Review Source Type: research
New UArizona study links brain waves directly to memory
The findings could lay foundations for cognitive impairment therapy and help improve memory.
Niranjana Rajalakshmi
Today
University CommunicationsOscillations feature.jpgHealthCollege of ScienceExpertsResearch
Media contact(s)Niranjana Rajalakshmi
Science Writer, University Communicationsniranjanar@arizona.edu917-415-3497
Researcher contact(s)Arne Ekstrom
Department of Psychologyadekstrom@email.arizona.edu520-621-4594Neurons produce rhythmic patterns of electrical activity in the brain. One of the unsettled questions in the field of neuroscience is what primarily drives these rhythmic signals, called oscillations. U...
Source: The University of Arizona: Health - July 31, 2023 Category: Universities & Medical Training Authors: niranjanar Source Type: research
Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance
Neurochem Res. 2023 Jul 26. doi: 10.1007/s11064-023-03983-z. Online ahead of print.ABSTRACTHot peppers, also called chilli, chilli pepper, or paprika of the plant genus Capsicum (family Solanaceae), are one of the most used vegetables and spices worldwide. Capsaicin (8-methyl N-vanillyl-6-noneamide) is the main pungent principle of hot green and red peppers. By acting on the capsaicin receptor or transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1), capsaicin selectively stimulates and in high doses defunctionalizes capsaicin-sensitive chemonociceptors with C and Aδ afferent fibers. This channe...
Source: Neurochemical Research - July 26, 2023 Category: Neuroscience Authors: Omar M E Abdel-Salam Gyula M ózsik Source Type: research
Preventing development of post-stroke hyperexcitability by optogenetic or pharmacological stimulation of cortical excitatory activity
Neurobiol Dis. 2023 Jul 17;184:106233. doi: 10.1016/j.nbd.2023.106233. Online ahead of print.ABSTRACTStroke is the most common cause of acquired epilepsy, but treatment for preventing the development of post-stroke epilepsy is still unavailable. Since stroke results in neuronal damage and death as well as initial loss of activity in the affected brain region, homeostatic plasticity may be trigged and contribute to an increase in network hyperexcitability that underlies epileptogenesis. Correspondingly, enhancing brain activity may inhibit hyperexcitability from enhanced homeostatic plasticity and prevent post-stroke epilep...
Source: Neurobiology of Disease - July 19, 2023 Category: Neurology Authors: Yadav Adhikari Cun-Gen Ma Zhi Chai Xiaoming Jin Source Type: research
