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Triggers of Anaphylaxis in Mastocytosis Patients: Evidence of the Current Drug-Avoidance Recommendation
Opinion statementMastocytosis is associated with a high risk of anaphylaxis, in part due to drug hypersensitivity reactions (DHR). Drugs associated with mast cell activation include nonsteroidal anti-inflammatory drugs (NSAIDs), drugs used in the perioperative setting, including general anesthetics, neuromuscular blocking agents (NMBAs) and opiates/opioids, radiocontrast media (RCM), vaccines, and antibiotics such as quinolones and vancomycin. To protect patients against DHR and anaphylaxis, general avoidance of potential drug triggers is common practice, which often deprives patients of important drugs at times of need an...
Source: Current Treatment Options in Allergy - September 20, 2023 Category: Allergy & Immunology Source Type: research

Neuromuscular blocking agent re-exposure in a retrospective cohort with neuromuscular blocking agent-associated anaphylaxis
CONCLUSION: Chemical structural similarities may contribute to the cross-reactivity of NMBAs in skin tests. Despite the high negative predictability of skin tests for suspected NMBA-induced anaphylaxis, the potential risk of recurrent anaphylaxis has not been eliminated.PMID:37356714 | DOI:10.1016/j.anai.2023.06.023
Source: Annals of Allergy, Asthma and Immunology - June 25, 2023 Category: Allergy & Immunology Authors: Jiung Jeong Jeong-Eun Yun Hyun Jee Kim Ji-Young Jang Jang Ho Seo Suh Young Lee Won Ho Kim Jeong-Hwa Seo Hye-Ryun Kang Source Type: research

Perioperative aspects of anaphylaxis
Orv Hetil. 2023 Jun 4;164(22):871-877. doi: 10.1556/650.2023.32789. Print 2023 Jun 4.ABSTRACTAnaphylaxis is a generalized, severe, life-threatening reaction, mostly with an allergic origin. Triggers are usually drugs, insect bites, poisons, contrast material and food. It is caused by various mediators (histamine, prostaglandins, leukotrienes etc.) released from mast cells, basophilic granulocytes. Histamine plays a central role in its creation. Immediate recognition and specific treatment instantaneously are essential for successful treatment. In severe conditions, the clinical features are very similar, regardless of thei...
Source: Orvosi Hetilap - June 4, 2023 Category: General Medicine Authors: Bal ázs Sütő Kamilla Domokos Source Type: research

A Patient with Known Allergy to Local Anesthesia Presenting for a Dental Restoration
Dentists should be equipped to treat an allergic reaction in a dental office, and in this scenario, the potential allergic reaction is noted after administration of a common local anesthetic lidocaine with epinephrine. The allergic reaction quickly escalates to a full-blown anaphylaxis, and the management of such an episode is detailed in this article.
Source: Dental Clinics of North America - April 7, 2023 Category: Dentistry Authors: Nikhil Mistry, Kenneth Kufta, Mel Mupparapu, Neeraj Panchal Source Type: research

Pholcodine cough medicines withdrawn in UK over allergy fears
Pharmacists told to stop supplying 20 brands after review finds raised risk of rare anaphylaxis in people who later have general anaestheticHealth officials have withdrawn 20 brands of dry cough medicine amid concerns they can trigger sudden, life-threatening allergic reactions in people who go on to have a general anaesthetic before surgery up to a year later.Pharmacists have been ordered to stop supplying medicines that contain the cough suppressant pholcodine immediately and to quarantine all remaining stock before returning the products to the relevant supplier.Continue reading...
Source: Guardian Unlimited Science - March 14, 2023 Category: Science Authors: Ian Sample Science editor Tags: Health UK news Drugs Pharmaceuticals industry Source Type: news

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