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Condition: Septic Shock
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Clinical Features and Outcome of Infective Endocarditis in a University Hospital in Romania
Conclusions: Staphylococcus aureus IE was associated with the presence of large vegetations, prosthetic valve endocarditis and intracardiac abscess. Coagulase negative Staphylococcus (CoNS) infection was associated with prosthetic valve dysfunction. Streptococcus gallolyticus etiology correlated with ischemic embolic stroke and the presence of large vegetations. Cardiovascular surgery was recommended in 67.4% of patients but was performed only on half of them. In hospital death occurred in 33.7% of patients and independent predictors of mortality were congestive heart failure and septic shock.PMID:33578787 | DOI:10.3390/medicina57020158
Source: Medicina (Kaunas) - February 13, 2021 Category: Universities & Medical Training Authors: Emilia Elena Babe ș Diana Anca Lucu ța Codru ța Diana Petcheși Andreea Atena Zaha Cristian Ilyes Alexandru Daniel Jurca Cosmin Mihai Vesa Dana Carmen Zaha Vlad Victor Babe ș Source Type: research
Intravenous immunoglobulin for overwhelming postsplenectomy infection
Kensuke Nakamura, Yuji Takahashi, Tomohiro Sonoo, Hideki HashimotoJournal of Global Infectious Diseases 2021 13(1):44-51Overwhelming postsplenectomy infection (OPSI) is a life-threatening condition causing fulminant bacteremia in asplenic patients. Intravenous immunoglobulin (IVIG) therapy is theoretically effective for OPSI. Herein, we present a case of OPSI treated successfully with IVIG, along with results of a literature review. An asplenic 70-year-old male with acute ischemic stroke presented with rapid and fulminant septic shock from pneumococcus pneumonia and bacteremia. Resuscitation and antibiotics including IVIG ...
Source: Journal of Global Infectious Diseases - February 26, 2021 Category: Infectious Diseases Authors: Kensuke Nakamura Yuji Takahashi Tomohiro Sonoo Hideki Hashimoto Source Type: research
Clinical Features and Outcome of Infective Endocarditis in a University Hospital in Romania
Conclusions: Staphylococcus aureus IE was associated with the presence of large vegetations, prosthetic valve endocarditis and intracardiac abscess. Coagulase negative Staphylococcus (CoNS) infection was associated with prosthetic valve dysfunction. Streptococcus gallolyticus etiology correlated with ischemic embolic stroke and the presence of large vegetations. Cardiovascular surgery was recommended in 67.4% of patients but was performed only on half of them. In hospital death occurred in 33.7% of patients and independent predictors of mortality were congestive heart failure and septic shock.PMID:33578787 | DOI:10.3390/medicina57020158
Source: Medicina (Kaunas) - February 13, 2021 Category: Universities & Medical Training Authors: Emilia Elena Babe ș Diana Anca Lucu ța Codru ța Diana Petcheși Andreea Atena Zaha Cristian Ilyes Alexandru Daniel Jurca Cosmin Mihai Vesa Dana Carmen Zaha Vlad Victor Babe ș Source Type: research
Machine learning methods to improve bedside fluid responsiveness prediction in severe sepsis or septic shock: an observational study, British journal of anaesthesia
Conclusions: Machine learning generated several models for predicting fluid responsiveness that were comparable with the haemodynamic response to PLR.
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news
β1-blocker in sepsis
ConclusionAccumulating evidence is supporting the use of ultrashort-acting β1-blockers while larger randomized controlled trials to clarify the effect of ultrashort-acting β1-blockers are still warranted.
Source: Journal of Intensive Care - May 8, 2021 Category: Intensive Care Source Type: research
Ulinastatin as an Adjuvant Therapy to Restricting Volumes of Resuscitation Fluid Strategy for Patients with Septic Shock after Initial Management
In this study, we compared the clinical efficacy of restricting volumes of resuscitation fluid strategy with or without intravenous infusion of ulinastatin (UTI) in treating patients with septic shock and additionally examined the patient's changes of the extravascular lung water index (EVLWI), pulmonary vascular permeability index (PVPI), systemic vascular resistance index (SVRI), cardiac function, lactic acid (LA) level, coagulation function, and renal function. The study included 182 patients with septic shock, among which 89 patients had undergone restricting volumes of resuscitation fluid strategy with intravenous inf...
Source: Evidence-based Complementary and Alternative Medicine - July 5, 2021 Category: Complementary Medicine Authors: Rensong Dong Xi Zhang Zhi Zhao Source Type: research
Accuracy of pulse pressure variations for fluid responsiveness prediction in mechanically ventilated patients with biphasic positive airway pressure mode
AbstractThe accuracy of pulse pressure variation (PPV) to predict fluid responsiveness using pressure-controlled (PC) instead of volume-controlled modes is under debate. To specifically address this issue, we designed a study to evaluate the accuracy of PPV to predict fluid responsiveness in severe septic patients who were mechanically ventilated with biphasic positive airway pressure (BIPAP) PC-ventilation mode. 45 patients with sepsis or septic shock and who were mechanically ventilated with BIPAP mode and a target tidal volume of 7 –8 ml/kg were included. PPV was automatically assessed at baseline and after a standar...
Source: Journal of Clinical Monitoring and Computing - December 5, 2021 Category: Information Technology Source Type: research
Esmolol response in septic shock patients in relation to vascular waterfall phenomenon measured by critical closure pressure and mean systemic filling pressure: a prospective observational study
ConclusionPatients with septic shock whose heart rate is greater than 95 beats/min after hemodynamic optimization were treated with esmolol, which could effectively control heart rate and reduce CI, as well as improve Pcc and increase the difference between Pcc and Pmsf (known as “vascular waterfall” phenomenon), without affecting MAP, CVP, Pmsf and arteriovenous vascular resistance, and improve the balance of oxygen supply and demand in the body.
Source: Journal of Intensive Care - January 4, 2022 Category: Intensive Care Source Type: research
RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages
In this study, we investigated the crosstalk between RANK and TLR4 pathways in macrophages stimulated with both RANKL and LPS to unveil the role of OPG in inflammatory processes. We found that RANKL inhibits TLR4 activation by binding to RANK, promoting the binding between TRAF6 and RANK, lowering TLR4 activation and the expression of proinflammatory mediators. Furthermore, high OPG levels aggravate inflammation by inhibiting RANKL. Our findings elect RANKL as a candidate for drug development as a way to mitigate the impact of obesity-induced inflammation in patients.PMID:35463988 | PMC:PMC9019442 | DOI:10.1155/2022/7740079
Source: Cell Research - April 25, 2022 Category: Cytology Authors: Ryerson Fonseca Mota Paulo Henrique Cavalcanti de Ara újo Maria Eduarda Ramos Cezine Fl ávia Sayuri Matsuo Rodrigo Jair Morandi Metzner Carlos Alberto Oliveira de Biagi Junior Kamila Chagas Peronni Hiroki Hayashi Munehisa Shimamura Hironori Nakagami Mar Source Type: research
