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Specialty: Biochemistry
Condition: SARS
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Total 1770 results found since Jan 2013.
Regulation of SARS-CoV-2 infection and antiviral innate immunity by ubiquitination and ubiquitin-like conjugation
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 15:194984. doi: 10.1016/j.bbagrm.2023.194984. Online ahead of print.ABSTRACTA global pandemic COVID-19 resulting from SARS-CoV-2 has affected a significant portion of the human population. Antiviral innate immunity is critical for controlling and eliminating the viral infection. Ubiquitination is extensively involved in antiviral signaling, and recent studies suggest that ubiquitin-like proteins (Ubls) modifications also participate in innate antiviral pathways such as RLR and cGAS-STING pathways. Notably, virus infection harnesses ubiquitination and Ubls modifications to faci...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Yi Zheng Huiyu Yang Xuejing Zhang Chengjiang Gao Source Type: research
Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions
In this study, we focus on the IPF and COVID-19 pathogenesis and the potential role of Apigenin in addressing disease progression.PMID:37707699 | DOI:10.1007/s11010-023-04845-6
Source: Molecular and Cellular Biochemistry - September 14, 2023 Category: Biochemistry Authors: Pritha Saha Priti Talwar Source Type: research
Effects of the glycosylation of the receptor binding domain (RBD dimer)-based Covid-19 vaccine (ZF2001) on its humoral immunogenicity and immunoreactivity
Int J Biol Macromol. 2023 Sep 12;253(Pt 3):126874. doi: 10.1016/j.ijbiomac.2023.126874. Online ahead of print.ABSTRACTThe SARS-CoV-2 spike protein receptor-binding domain (RBD), which is a key target for the development of SARS-CoV-2 neutralizing antibodies and vaccines, mediates the binding of the host receptor angiotensin-converting enzyme 2 (ACE2). However, the high heterogeneity of RBD glycoforms may lead to an incomplete neutralization effect and impact the immunogenicity of RBD-based vaccines (Ye et al., 2021). Here, our data suggested that the glycosylation significantly affected the humoral immunogenicity and immun...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Xueqing Wang Lulu Shi Yirong Wang Jia Chen Zelan Yang Chenglong Liu Xiaomei Liu Yang Li Can Zhang Anhui Sun Huan Yan Hui Sun Source Type: research
Nucleic Acid Detection through RNA-Guided Protease Activity in Type III-E CRISPR-Cas Systems
Chembiochem. 2023 Sep 14:e202300401. doi: 10.1002/cbic.202300401. Online ahead of print.ABSTRACTRNA-guided protease activity was recently discovered in the type III-E CRISPR-Cas systems (Craspase), providing a novel platform for engineering a protein probe instead of the commonly used nucleic acid probe in the nucleic acid detection assays. Here, by adapting a fluorescence readout technique using the affinity- and fluorescent protein dual-tagged Csx30 protein substrate, we established an assay monitoring Csx30 cleavage by target ssRNA-activated Craspase. Four Craspase-based nucleic acid detection systems for genes from sev...
Source: Chembiochem - September 14, 2023 Category: Biochemistry Authors: Qiuqiu He Xinlong Lei Yuanjun Liu Xiaoshen Wang Nan Ji Hang Yin Huiping Wang Heng Zhang Guimei Yu Source Type: research
Effects of the glycosylation of the receptor binding domain (RBD dimer)-based Covid-19 vaccine (ZF2001) on its humoral immunogenicity and immunoreactivity
Int J Biol Macromol. 2023 Sep 12:126874. doi: 10.1016/j.ijbiomac.2023.126874. Online ahead of print.ABSTRACTThe SARS-CoV-2 spike protein receptor-binding domain (RBD), which is a key target for the development of SARS-CoV-2 neutralizing antibodies and vaccines, mediates the binding of the host receptor angiotensin-converting enzyme 2 (ACE2). However, the high heterogeneity of RBD glycoforms may lead to an incomplete neutralization effect and impact the immunogenicity of RBD-based vaccines (Ye et al., 2021). Here, our data suggested that the glycosylation significantly affected the humoral immunogenicity and immunoreactivit...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Xueqing Wang Lulu Shi Yirong Wang Jia Chen Zelan Yang Chenglong Liu Xiaomei Liu Yang Li Cang Zhang Anhui Sun Huan Yan Hui Sun Source Type: research
Nucleic Acid Detection through RNA-Guided Protease Activity in Type III-E CRISPR-Cas Systems
Chembiochem. 2023 Sep 14:e202300401. doi: 10.1002/cbic.202300401. Online ahead of print.ABSTRACTRNA-guided protease activity was recently discovered in the type III-E CRISPR-Cas systems (Craspase), providing a novel platform for engineering a protein probe instead of the commonly used nucleic acid probe in the nucleic acid detection assays. Here, by adapting a fluorescence readout technique using the affinity- and fluorescent protein dual-tagged Csx30 protein substrate, we established an assay monitoring Csx30 cleavage by target ssRNA-activated Craspase. Four Craspase-based nucleic acid detection systems for genes from sev...
Source: Chembiochem - September 14, 2023 Category: Biochemistry Authors: Qiuqiu He Xinlong Lei Yuanjun Liu Xiaoshen Wang Nan Ji Hang Yin Huiping Wang Heng Zhang Guimei Yu Source Type: research
An engineered bispecific nanobody in tetrameric secretory IgA format confers broad neutralization against SARS-CoV-1 & amp;2 and its' most variants
This study provides an effective weapon combating SARS-CoV-2, proposes a new strategy overcoming the virus escape, and lays strategic reserves for rapid response to potential future outbreaks of "SARS-CoV-3".PMID:37690653 | DOI:10.1016/j.ijbiomac.2023.126817
Source: International Journal of Biological Macromolecules - September 10, 2023 Category: Biochemistry Authors: Weihong Zeng Xiaoying Jia Xiangyang Chi Xinghai Zhang Entao Li Yan Wu Yang Liu Jin Han Kang Ni Xiaodong Ye Xiaowen Hu Huan Ma Changming Yu Sandra Chiu Tengchuan Jin Source Type: research
RNA-dependent RNA polymerase of SARS-CoV-2 regulate host mRNA translation efficiency by hijacking eEF1A factors
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 4:166871. doi: 10.1016/j.bbadis.2023.166871. Online ahead of print.ABSTRACTThe RNA-dependent RNA polymerase (NSP12) of COVID-19 plays a significant role in the viral infection process, which promotes viral RNA replication by cooperating with NSP7 and NSP8, but little is known about its regulation on the function of host cells. We firstly found that overexpression of NSP12 had little effect on host mRNAs transcription. Using iCLIP technology, we found that NSP12 can bind a series of host RNAs with the conserved binding motif G(C/A/G)(U/G/A)UAG, especially ribosomal RNA. We found ...
Source: Biochimica et Biophysica Acta - September 6, 2023 Category: Biochemistry Authors: Haili Gan Xiaoguang Zhou Qiong Lei Linlin Wu Jianmin Niu Qingliang Zheng Source Type: research
The basis of complications in the context of SARS-CoV-2 infection: Pathological activation of ADAM17
Biochem Biophys Res Commun. 2023 Aug 31;679:37-46. doi: 10.1016/j.bbrc.2023.08.063. Online ahead of print.ABSTRACTThe virulence of SARS-CoV-2 decreases with increasing infectivity, the primary approaches for antiviral treatments will be preventing or minimizing the complications resulting from virus infection. ADAM metallopeptidase domain 17 (ADAM17) activation by SARS-CoV-2 infection has a dual effect on the development of the disease: increased release of inflammatory cytokines and dysregulation of Angiotensin converting enzyme II (ACE2) on cell surfaces, inflammatory cytokine infiltration and loss of ACE2 protective fun...
Source: Biochemical and Biophysical Research communications - September 4, 2023 Category: Biochemistry Authors: Shenghai Jiang Hao Yang Zhongming Sun Yi Zhang Yan Li Jida Li Source Type: research
