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Specialty: Molecular Biology
Condition: SARS
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Total 3259 results found since Jan 2013.
Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn(ii), Co(ii) and Ni(ii) complexes - combined experimental and theoretical measurements towards DNA/BSA/SARS-CoV-2 3CL < sup > Pro < /sup >
RSC Med Chem. 2023 Jan 3;14(9):1667-1697. doi: 10.1039/d2md00394e. eCollection 2023 Sep 19.ABSTRACTA novel class of bioactive complexes (1-3) [MII(L)2(bpy)], where, L = 2-(4-morpholinobenzylideneamino)phenol, bpy = 2,2'-bipyridine, MII = Mn (1), Co (2) or Ni (3), were assigned to octahedral geometry based on analytical and spectral measurements. Gel electrophoresis showed that complex (2) demonstrated significant DNA cleavage activity compared to the other complexes under the action of oxidation agent (H2O2). The DNA binding constant properties measured by various techniques were in the following sequence: (2) > (3) >...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Karunganathan Sakthikumar Bienfait Kabuyaya Isamura Rui Werner Ma çedo Krause Source Type: research
Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing
In this study, we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase (IEDB) database. We first analyzed SARS-CoV-2 spike (S) and nucleoprotein (N), which are two common targets of the immune response and well studied in both human and mouse systems. We observed a weak but statistically significant correlation between human and H-2b mouse T-cell responses (CD8 S specific (r = 0.206, p = 1.37 × 10-13); CD4 S specific (r = 0.118, p = 2.63 × 10-5) and N specific (r = 0.179, p = 2.55 × 10-4)). Due to intrinsic differences in MHC molecules acro...
Source: Cellular and Molecular Immunology - September 19, 2023 Category: Molecular Biology Authors: Tertuliano Alves Pereira Neto John Sidney Alba Grifoni Alessandro Sette Source Type: research
Recombinant Antibodies to Face SARS-CoV-2 Syndemic
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):24-27. doi: 10.14715/cmb/2023.69.7.4.ABSTRACTIn recent years, increasing interest has been paid to using antibody-based therapies for clinical applications. However, it is unclear whether recombinant antibodies can be combined with other scientific approaches to generate innovative solutions for mitigating severe acute respiratory syndrome coronavirus 2. In this context, the increase in this virus transmission, the number of infected people, and the interaction between social and biological processes have led to a syndemic, exacerbating the public health problem. Here, we a...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Maykel Gonz ález Torres Gerardo Leyva G ómez Mar ía Luisa Del Prado-Audelo Hern án Cortés Jonathan J Maga ña Source Type: research
Integrated Immunopeptidomics and Proteomics Study of SARS-CoV-2 Infected Calu-3 Cells Reveals Dynamic Changes in Allele-specific HLA Abundance and Antigen Presentation
We present an integrated immunopeptidomics and proteomics study of SARS-CoV-2 infection to comprehensively decipher the changes in host cells in response to viral infection. Immunopeptidomics analysis identified viral antigens presented by host cells through both Class I and Class II MHC system for recognition by the adaptive immune system. The host proteome changes were characterized by quantitative proteomics and glycoproteomics and from these data, the activation of TLR3-interferon pathway was identified. Glycosylation analysis of HLA proteins from the elution and flow-through of immunoprecipitation revealed that SARS-C...
Source: Molecular and Cellular Proteomics : MCP - September 14, 2023 Category: Molecular Biology Authors: Rui Chen Kelly M Fulton Anh Tran Diana Duque Kevin Kovalchik Etienne Caron Susan M Twine Jianjun Li Source Type: research
Airway Basal Stem Cells in COVID-19 Exhibit a Proinflammatory Signature and Impaired Mucocililary Differentiation
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:37699145 | DOI:10.1165/rcmb.2023-0104OC
Source: Mol Biol Cell - September 12, 2023 Category: Molecular Biology Authors: Kamakshi Bankoti Wei Wang Gaurang M Amonkar Linjie Xiong Jessica E Shui Caiqi Zhao Eric Van Chimwemwe Mwase Jin-Ah Park Hongmei Mou Yinshan Fang Jianwen Que Yan Bai Paul H Lerou Xingbin Ai Source Type: research
Importance of screening severe COVID-19 patients for IFN- λ1, IL-6 and anti-S1 IgG levels
The objective of this study is to screen IFN-λ1, IL-6 and antibody levels in consecutive serum sample sets of COVID-19 patients. A total of 365 serum samples collected from 208 hospitalized COVID-19 patients were analyzed for IFN-λ1 and IL-6 levels as well as SARS-CoV-2 neutralizing antibodies and anti-S1 IgG antibodies. Analyses of serum samples for cytokine levels showed that IFN-λ1 (>8 pg/mL) and IL-6 (>2 pg/mL) were detected in approximately 64% and 21% patients, respectively. A decrement in IFN-λ1 levels and IL-6 levels above 35 pg/mL can be sign of clinical severity and upcoming dead. An increment in IL-6 l...
Source: Cytokine - September 10, 2023 Category: Molecular Biology Authors: Olcay Buse Kenano ğlu Ayt ül Gül H üseyin Can Muhammet Karakavuk Sedef Erkunt Alak G ülay Korukluoğlu Ay şe Başak Altaş H üsnü Pullukçu Aysu De ğirmenci Döşkaya Tu ğba Karakavuk Ceren G ül Candan Çiçek Mehmet Sezai Ta şbakan Ak ın Çi Source Type: research
Inflammatory and cytotoxic mediators in COVID-19 patients and in ChAdOx1 nCoV-19 (AZD1222) vaccine recipients
Cytokine. 2023 Sep 4;171:156350. doi: 10.1016/j.cyto.2023.156350. Online ahead of print.ABSTRACTImmunological and cytotoxic mediators are induced in natural infection and are essential for the effectiveness of vaccination. Vaccination is useful to prevent the spread of SARS-CoV-2 and limit the morbidity/mortality of COVID-19. ChAdOx1 nCoV-19 is one of the most widespread vaccines in the world. We compared the detection of anti-S1 SARS-CoV2 IgG and the profile of inflammatory and cytotoxic responses of patients who developed different clinical outcomes of COVID-19 with individuals previously exposed or not to the virus rece...
Source: Cytokine - September 6, 2023 Category: Molecular Biology Authors: D ébora Familiar-Macedo Paulo Vieira Damasco Victor Edgar Fiestas Sol órzano Joyce Carnevale Rodrigues Elba Regina Sampaio de Lemos Fl ávia Barreto Dos Santos Marilda Agudo Mendon ça Teixeira de Siqueira Elzinandes Leal de Azeredo Luzia Maria de-Olive Source Type: research
