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Condition: Diabetes

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Total 118587 results found since Jan 2013.

Quality improvement strategies for diabetes care:  Effects on outcomes for adults living with diabetes
CONCLUSIONS: There is a significant body of evidence about QI programmes to improve the management of diabetes. Multicomponent QI programmes for diabetes care (comprised of effective QI strategies) may achieve meaningful population-level improvements across the majority of outcomes. For health system decision-makers, the evidence summarised in this review can be used to identify strategies to include in QI programmes. For researchers, this synthesis identifies higher-priority QI strategies to examine in further research regarding how to optimise their evaluation and effects. We will maintain this as a living systematic rev...
Source: Cochrane Database of Systematic Reviews - May 31, 2023 Category: General Medicine Authors: Sharlini Yogasingam Kristin J Konnyu Johanie L épine Katrina Sullivan Mostafa Alabousi Alun Edwards Michael Hillmer Sathya Karunananthan John N Lavis Stefanie Linklater David Moher Braden J Manns Sameh Mortazhejri Samir Nazarali P Alison Paprica Timothy Source Type: research

Interventions for motor rehabilitation in people with transtibial amputation due to peripheral arterial disease or diabetes
CONCLUSIONS: Overall, there is a paucity of research in the field of motor rehabilitation in dysvascular amputation. We identified very low-certainty evidence that gait training protocols showed little or no difference between the groups in mobility assessments and adverse events. MI combined with physical practice of walking versus physical practice of walking alone showed no clear difference in mobility assessment (very low-certainty evidence). The included studies did not report mortality, QoL, and phantom limb pain, and evaluated participants already using prosthesis, precluding the evaluation of prosthesis use. Due to...
Source: Cochrane Database of Systematic Reviews - June 5, 2023 Category: General Medicine Authors: Luciane B Aledi Carolina Dq Flumignan Virginia Fm Trevisani Fausto Miranda Source Type: research

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease
CONCLUSIONS: There is currently insufficient evidence to determine the effectiveness of ACEi or ARB in patients with stage 1 to 3 CKD who do not have DM. The available evidence is overall of very low certainty and high risk of bias. We have identified an area of large uncertainty for a group of patients who account for most of those diagnosed as having CKD.PMID:37466151 | PMC:PMC10355090 | DOI:10.1002/14651858.CD007751.pub3
Source: Cochrane Database of Systematic Reviews - July 19, 2023 Category: General Medicine Authors: Tess E Cooper Claris Teng David J Tunnicliffe Brydee A Cashmore Giovanni Fm Strippoli Source Type: research

Dressings and topical agents containing hyaluronic acid for chronic wound healing
CONCLUSIONS: There is currently insufficient evidence to determine the effectiveness of hyaluronic acid dressings in the healing of pressure ulcers or foot ulcers in people with diabetes. We found evidence that hyaluronic acid probably improves complete ulcer healing and may slightly decrease pain and increase change in ulcer size when compared with neutral vehicle. Future research into the effects of hyaluronic acid in the healing of chronic wounds should consider higher sample size and blinding to minimise bias and improve the quality of evidence.PMID:37497805 | PMC:PMC10373121 | DOI:10.1002/14651858.CD012215.pub2
Source: Cochrane Database of Systematic Reviews - July 27, 2023 Category: General Medicine Authors: Hellen Roehrs Janislei Gd Stocco Franciele Pott Gisely Blanc Marineli J Meier Fernando Al Dias Source Type: research

Doing Your Own Research
By David Spero Doctors used to be the only source of medical information. Not anymore. You can get much of the same information on the Internet. Problem is, not all of the information you'll come across online is good. Here are some ways to empower yourself with good Internet research: • It's good to have some general "search engine" sites as a starting point on your quest for information. I usually start with Google. Yahoo and Bing are also good. Search engine sites will give you a list of more specific sites where you can get the information you seek. For example, a Google search for "diabetes" gives over 70 milli...
Source: Diabetes Self-Management - August 6, 2014 Category: Diabetes Authors: David Spero Source Type: blogs

SLCO1B1 Polymorphisms and Statin-Induced Myopathy
Clinical scenario Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors which reduce the risk of coronary events and death by lowering blood concentrations of low density lipoprotein cholesterol (LDL-c).1,2,3,4 They are generally regarded as safe and well tolerated. However, some patients experience adverse muscle symptoms; these are mostly relatively mild but, in rare cases, severe muscle damage with renal failure (rhabdomyolysis) may occur (reviewed in 5,6). Recently, an autoimmune form of necrotising myositis has also been identified as a rare statin-associated myopathy (reviewed in 7). There ...
Source: PLOS Currents Evidence on Genomic Tests - December 4, 2013 Category: Genetics & Stem Cells Authors: Alison Stewart Source Type: research

Medline, PubMed, or both?
A question raised in a recent teaching session with MSc students undertaking systematic reviews.  Should I search Medline and PubMed?Actually, people don't usually ask the question, but instead tell you that they have searched both, or that someone has recommended they do so, or that they have read a review where the reviewers have searched both.I always say I am not convinced you need to search both.  But am I right?I know PubMed includes things that Medline does not:1. Medline indexes some journals (like Science and Nature) selectively, and will not include non biomedical / life science articles.  PubMed, ...
Source: Browsing - April 18, 2015 Category: Databases & Libraries Tags: medline pubmed systematic reviews Source Type: blogs

Post Publication Review: Librarians’ Role
This study highlights the need for more accurate and comprehensive reporting needed for search strategies in systematic reviews and other literature search-based research syntheses, and the need for better peer review of search strategies by information specialists/medical librarians. Though the searches in the Appendix are on face value replicable and high quality, on closer inspection, they do not in fact meet the reporting standards as outlined by PRISMA Statement items #7 and #8: “Describe all information sources in the search (e.g., databases with dates of coverage, contact with study authors to identify additional ...
Source: The Krafty Librarian - April 6, 2016 Category: Databases & Libraries Authors: KraftyLibrarian Tags: Uncategorized Source Type: blogs

Post Publication Review: Librarians ’ Role
This study highlights the need for more accurate and comprehensive reporting needed for search strategies in systematic reviews and other literature search-based research syntheses, and the need for better peer review of search strategies by information specialists/medical librarians. Though the searches in the Appendix are on face value replicable and high quality, on closer inspection, they do not in fact meet the reporting standards as outlined by PRISMA Statement items #7 and #8: “Describe all information sources in the search (e.g., databases with dates of coverage, contact with study authors to identify additional ...
Source: The Krafty Librarian - April 6, 2016 Category: Databases & Libraries Authors: KraftyLibrarian Tags: Uncategorized Source Type: blogs

A Systematic Comparison of Linear Regression –Based Statistical Methods to Assess Exposome-Health Associations
Conclusions: Correlation between exposures is a challenge for exposome research, and the statistical methods investigated in this study were limited in their ability to efficiently differentiate true predictors from correlated covariates in a realistic exposome context. Although GUESS and DSA provided a marginally better balance between sensitivity and FDP, they did not outperform the other multivariate methods across all scenarios and properties examined, and computational complexity and flexibility should also be considered when choosing between these methods. Citation: Agier L, Portengen L, Chadeau-Hyam M, Basagaña X...
Source: EHP Research - December 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Articles December 2016 Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research

Body Composition and Body Weight Changes at Different Altitude Levels: A Systematic Review and Meta-Analysis
In conclusion, BW and body composition changes occur during sojourns at different altitudes. The mechanisms leading to these changes are manifold and the magnitude of change is, in addition to the individual adaptive response to hypoxia, greatly influenced by the AL, the duration of the stay, the level of physical activity and the nutritional intake. This review identifies at least two contrasting motivations for hypoxia exposure; the experience of high altitude mountaineering and the “therapeutic” effect of hypoxia (e.g., weight loss programs). This analytical review of published data highlights the notion t...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

World-Wide Efficacy of Bone Marrow Derived Mesenchymal Stromal Cells in Preclinical Ischemic Stroke Models: Systematic Review and Meta-Analysis
Conclusions: Our results show worldwide efficacy of BM-MSCs in improving functional outcomes in pre-clinical animal models of stroke and support testing these cells in clinical trials in various ranges of time windows using different delivery routes. The continued growing number of publications showing functional benefit of BM-MSCs are now adding limited value to an oversaturated literature spanning 18 years. Researchers should focus on identifying definitive mechanisms on how BM-MSCs lead to benefit in stroke models. Introduction Ischemic stroke is the 5th leading cause of death and the leading cause of long term di...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

COVID-19 and its cardiovascular effects: a systematic review of prevalence studies
CONCLUSIONS: This systematic literature review indicates that cardiometabolic comorbidities are common in people who are hospitalised with a COVID-19 infection, and cardiovascular complications are frequent. We plan to update this review and to conduct a formal meta-analysis of outcomes based on a more homogeneous selected subsample of high-certainty studies.PMID:33704775 | DOI:10.1002/14651858.CD013879
Source: Cochrane Database of Systematic Reviews - March 11, 2021 Category: General Medicine Authors: Pierpaolo Pellicori Gemina Doolub Chih Mun Wong Keng Siang Lee Kenneth Mangion Mahmood Ahmad Colin Berry Iain Squire Pier D Lambiase Alexander Lyon Alex McConnachie Rod S Taylor John Gf Cleland Source Type: research

Oral dextrose gel to prevent hypoglycaemia in at-risk neonates
CONCLUSIONS: Oral dextrose gel reduces the risk of neonatal hypoglycaemia in at-risk infants and probably reduces the risk of major neurological disability at two years of age or greater without increasing the risk of adverse events compared to placebo gel. Additional large follow-up studies at two years of age or older are required. Future research should also be undertaken in low- and middle-income countries, preterm infants, using other dextrose gel preparations, and using comparators other than placebo gel. There are three studies awaiting classification and one ongoing study which may alter the conclusions of the revi...
Source: Cochrane Database of Systematic Reviews - May 17, 2021 Category: General Medicine Authors: Taygen Edwards Gordon Liu Joanne E Hegarty Caroline A Crowther Jane Alsweiler Jane E Harding Source Type: research