Filtered By:
Specialty: Biomedical Science
Condition: Diabetes
This page shows you your search results in order of relevance.
Order by Relevance | Date
Total 298 results found since Jan 2013.
Neutrophil extracellular traps regulate ischemic stroke brain injury
In this study, we investigated mechanistic regulators of neutrophil extracellular trap (NET) formation in stroke and whether they contribute to stroke outcomes. NET-forming neutrophils were found throughout brain tissue of ischemic stroke patients, and elevated plasma NET biomarkers correlated with worse stroke outcomes. Additionally, we observed increased plasma and platelet surface–expressed high-mobility group box 1 (HMGB1) in stroke patients. Mechanistically, platelets were identified as the critical source of HMGB1 that caused NETs in the acute phase of stroke. Depletion of platelets or platelet-specific knockout of...
Source: Journal of Clinical Investigation - May 16, 2022 Category: Biomedical Science Authors: Frederik Denorme, Irina Portier, John L. Rustad, Mark J. Cody, Claudia V. de Araujo, Chieko Hoki, Matthew D. Alexander, Ramesh Grandhi, Mitchell R. Dyer, Matthew D. Neal, Jennifer J. Majersik, Christian C. Yost, Robert A. Campbell Source Type: research
Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors
Conclusions Despite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables.
Source: Advances in Medical Sciences - October 3, 2017 Category: Biomedical Science Source Type: research
Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors.
CONCLUSIONS: Despite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables.
PMID: 28985592 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - October 3, 2017 Category: Biomedical Science Authors: Colello MJ, Ivey LE, Gainey J, Faulkner RV, Johnson A, Brechtel L, Madeline L, Nathaniel TI Tags: Adv Med Sci Source Type: research
Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors
ConclusionsDespite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables.
Source: Advances in Medical Sciences - July 5, 2018 Category: Biomedical Science Source Type: research
Stroke risk in hypertrophic cardiomyopathy patients with atrial fibrillation: a nationwide database study.
This study aimed to determine the incidence of stroke and its risk factors in HCM patients with AF during a long-term follow-up. Using a national database, we retrospectively investigated 18,724 HCM patients from a systematic sample of 1,000,000 Taiwanese people between 1997 and 2013. The incidences of AF and stroke were estimated. Data were analyzed using Cox regression models. AF was identified in 598 patients (262 men, mean age 66.3±13.0 years) during a median follow-up of 7.0 years. The AF incidence in HCM patients was 5.83 per 1000 person-years, and the overall incidence of AF-associated stroke was 24.14 per 1000 per...
Source: Aging - November 23, 2020 Category: Biomedical Science Authors: Hsu JC, Huang YT, Lin LY Tags: Aging (Albany NY) Source Type: research
Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons
Type 2 diabetes (T2D) hampers stroke recovery though largely undetermined mechanisms. Few preclinical studies have investigated the effect of genetic/toxin-induced diabetes on long-term stroke recovery. However, the effects of obesity-induced T2D are mostly unknown. We aimed to investigate whether obesity-induced T2D worsens long-term stroke recovery through the impairment of brain's self-repair mechanisms - stroke-induced neurogenesis and parvalbumin (PV)+ interneurons-mediated neuroplasticity. To mimic obesity-induced T2D in the middle-age, C57bl/6j mice were fed 12 months with high-fat diet and subjected to transient mi...
Source: Clinical Science - June 23, 2019 Category: Biomedical Science Authors: Pintana, H., Lietzau, G., Augestad, I. L., Chiazza, F., Nystrom, T., Patrone, C., Darsalia, V. Tags: PublishAheadOfPrint Source Type: research
Prior ischemic stroke is not associated with worse clinical outcomes in patients undergoing percutaneous coronary intervention.
Conclusions: This study demonstrates that, in daily clinical practice, PCI can be provided safely and with good results to patients with a prior ischemic stroke (≥3 months).
PMID: 25090258 [PubMed - as supplied by publisher]
Source: Clinical and Investigative Medicine - August 5, 2014 Category: Biomedical Science Authors: Zhang M, Guddeti RR, Wang SP, Wang J, Xin MK, Chen SJ, Kang JP, Lv Q, Ma CS, Liu JH Tags: Clin Invest Med Source Type: research
Obesity and mortality after the first ischemic stroke: Is obesity paradox real?
ConclusionOur study results support the obesity paradox in ischemic stroke patients as shown by a significantly decreased hazard ratio for one-year mortality among overweight and obese patients in comparison to non-overweight patients.
Source: PLoS One - February 10, 2021 Category: Biomedical Science Authors: Durgesh Chaudhary Source Type: research
Stress hyperglycemia may have higher risk of stroke recurrence than previously diagnosed diabetes mellitus
Aging (Albany NY). 2021 Mar 22;13. doi: 10.18632/aging.202797. Online ahead of print.ABSTRACTWe aim to evaluate the risk of stroke recurrence among non-diabetes mellitus (non-DM), previously diagnosed diabetes mellitus (PDDM), newly diagnosed diabetes mellitus-related hyperglycemia (NDDM-RH) and stress hyperglycemia after minor stroke or TIA. Totally, 3026 patients with baseline fasting glucose and glycated albumin from the CHANCE trial (Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events) were included. Patients were classified as non-DM, PDDM, NDDM-RH and stress hyperglycemia according to the...
Source: Aging - March 22, 2021 Category: Biomedical Science Authors: Yuzhou Guo Guangyao Wang Jing Jing Anxin Wang Xiaoli Zhang Xia Meng Xingquan Zhao Liping Liu Hao Li David Wang Yongjun Wang Yilong Wang Source Type: research
Risk factors of dysphagia in patients with ischemic stroke: A meta-analysis and systematic review
ConclusionsElder age, hypertension, diabetes and brainstem stroke are associated with the development of dysphagia in patients with ischemic stroke. Attention should be paid to the assessment and early intervention of those risk factors for dysphagia to improve the prognosis of stroke patients.
Source: PLoS One - June 16, 2022 Category: Biomedical Science Authors: Cui Yang Source Type: research
Serum Soluble Corin Deficiency Predicts Major Disability within 3 Months after Acute Stroke
ConclusionSerum soluble corin deficiency predicted risk for major disability within 3 months after stroke, independent of baseline neurological deficient. Our results may indicate a probable role of corin in stroke prognosis.
Source: PLoS One - September 21, 2016 Category: Biomedical Science Authors: Weidong Hu Source Type: research
CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study.
CONCLUSION: CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke.
PMID: 28245897 [PubMed - in process]
Source: Biomedical and Environmental Sciences : BES - December 31, 2016 Category: Biomedical Science Authors: Chen L, Sun KX, Juan J, Fang K, Liu K, Wang XY, Wang L, Yang C, Liu XQ, Li J, Tang X, Wu YQ, Qin XY, Wu T, Chen DF, Hu YH Tags: Biomed Environ Sci Source Type: research
Body mass index and stroke risk among patients with diabetes mellitus in Korea
ConclusionBMI was positively associated with the overall risk of stroke among DM patients in Korea. The risk of ischemic stroke was higher in obese patients compared to overweight or normal-weight patients. However, the risk of hemorrhagic stroke was higher in slimmer patients compared with overweight or obese patients.
Source: PLoS One - September 30, 2022 Category: Biomedical Science Authors: Do Kyeong Song Source Type: research
CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study
Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke.
Source: Biomedical and Environmental Sciences - March 3, 2017 Category: Biomedical Science Source Type: research
