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Elevated stress hyperglycemia and the presence of intracranial artery stenosis increase the risk of recurrent stroke
ConclusionsSHR represents a better biomarker to predict the risk of stroke recurrence in patients with ICAS than FPG and HbA1c regardless of previous diabetes mellitus.Trial registrationhttps://www.chictr.org.cn/showproj.aspx?proj=125817; Identifier, [ChiCTR2100046958].
Source: Frontiers in Endocrinology - January 9, 2023 Category: Endocrinology Source Type: research

Neuroimaging and Neurolaw: Drawing the Future of Aging
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, ...
Source: Frontiers in Endocrinology - April 7, 2019 Category: Endocrinology Source Type: research

Editorial: Telomeres and Epigenetics in Endocrinology
This study was hypothesis-driven; the genetic variants were selected for being previously and substantially genotyped. The big sample size and the rich panel of other biomarkers allowed the authors to conduct much more detailed analyses on this topic. The third article by Provenzi et al. proposed their perspectives on the role of telomeres in premature birth and discussed the potential implications for early adversity and care in the neonatal intensive care unit (Pavanello et al.). Indeed, the speculation of telomeres in aging begins in the premature aging syndrome. It is thus interesting to examine if telomeres also play...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Update on cardiovascular outcomes at 30 years of the diabetes control and complications trial/epidemiology of diabetes interventions and complications study.
CONCLUSIONS DCCT INT and the attendant 6.5 years of lower HbA1c had long-term salutary effects on the development and progression of atherosclerosis and cardiovascular disease during the subsequent follow-up during EDIC. PMID: 24356596 [PubMed - in process]
Source: Diabetes Care - December 23, 2013 Category: Endocrinology Authors: Lachin JM, Orchard TJ, Nathan DM, DCCT/EDIC Research Group Tags: Diabetes Care Source Type: research

Guideline treatment results in regression of atherosclerosis in type 2 diabetes mellitus
Conclusions: Guideline treatment arrests atherogenesis in non-diabetes mellitus patients and even decreases vessel wall dimensions in type II diabetes mellitus patients. Baseline body mass index predicts cardiovascular disease prevention efficacy expressed as decrease in total wall volume. These data emphasize the importance of optimal cardiovascular-prevention, particularly in diabetes patients with a high body mass index.
Source: Diabetes and Vascular Disease Research - February 17, 2015 Category: Endocrinology Authors: Strang, A. C., van Wijk, D. F., Mutsaerts, H. J., Stroes, E. S., Nederveen, A. J., Rotmans, J. I., Rabelink, T. J., Box, F. M. Tags: Original Articles Source Type: research

Testosterone and cardiac mass and function in men with type 1 diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)
ConclusionsAmong men with type 1 diabetes, higher total testosterone was associated with higher LV mass and volume but not with function. The clinical significance of this association remains to be established.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - December 7, 2015 Category: Endocrinology Authors: Catherine Kim, Ionut Bebu, Barbara Braffett, Patricia A. Cleary, Valerie Arends, Michael Steffes, Hunter Wessells, Trevor Orchard, Aruna V. Sarma, Tags: Original Article Source Type: research

Retinopathy: A Sign of Cerebral Small Vessel Disease in Diabetes?
This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - October 31, 2016 Category: Endocrinology Authors: Toshitaka Umemura, Takahiko Kawamura Tags: Commentary Source Type: research

Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes
CONCLUSIONS Pioglitazone improves whole-body and myocardial insulin sensitivity, LV diastolic function, and systolic function in T2D. Improved myocardial insulin sensitivity and diastolic function are strongly correlated.
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Clarke, G. D.; Solis-Herrera, C.; Molina-Wilkins, M.; Martinez, S.; Merovci, A.; Cersosimo, E.; Chilton, R. J.; Iozzo, P.; Gastaldelli, A.; Abdul-Ghani, M.; DeFronzo, R. A. Tags: Epidemiology-Diabetes Complications Pathophysiology/Complications Source Type: research

MELAS or Leigh syndrome, that's the question
Pediatr Endocrinol Diabetes Metab. 2021;27(4):311-312. doi: 10.5114/pedm.2022.112695.ABSTRACTWith interest we read the article by Baszyńska-Wilk et al. about a 12 years old female who was diagnosed with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome upon the clinical presentation, blood tests, and the cerebral magnetic resonance imaging (MRI) [1]. The diagnosis was neither confirmed by biochemical nor by genetic investigations [1]. The study is appealing but raises the following concerns.PMID:35114773 | DOI:10.5114/pedm.2022.112695
Source: Pediatric Endocrinology, Diabetes, and Metabolism - February 4, 2022 Category: Endocrinology Authors: Josef Finsterer Source Type: research

Is increased myocardial triglyceride content associated with early changes in left ventricular function? A 1H-MRS and MRI strain study
ConclusionsPredicting MTGC remains a challenge in routine clinical practice, as only BMI independently correlates with increased MTGC. MTGC may play a role in LV dysfunction but does not appear to be involved in the development of subclinical strain abnormalities.
Source: Frontiers in Endocrinology - June 22, 2023 Category: Endocrinology Source Type: research