Filtered By:
Specialty: Drugs & Pharmacology
Condition: Diabetes

This page shows you your search results in order of date. This is page number 9.

Order by Relevance | Date

Total 224 results found since Jan 2013.

Therapeutic Approaches Targeting Molecular Signaling Pathways Common to Diabetes and Lung Diseases and Cancer
Adv Drug Deliv Rev. 2021 Aug 7:113918. doi: 10.1016/j.addr.2021.113918. Online ahead of print.ABSTRACTDiabetes mellitus (DM), is the most common metabolic disease and is characterized by sustained hyperglycemia. Accumulating evidences supports a strong association between DM and numerous lung diseases including chronic obstructive pulmonary disease (COPD), fibrosis, and lung cancer (LC). The global incidence of DM-associated lung disorders is rising and several ongoing studies, including clinical trials, aim to elucidate the molecular mechanisms linking DM with lung disorders, in particular LC. Several potential mechanisms...
Source: Advanced Drug Delivery Reviews - August 10, 2021 Category: Drugs & Pharmacology Authors: Rajeswari Raguraman Akhil Srivastava Anupama Munshi Rajagopal Ramesh Source Type: research

Involvement of miR-199a-3p/DDR1 in vascular endothelial cell senescence in diabetes
In conclusion, our data demonstrated that miR-199a-3p/DDR1/p53/p21 signaling pathway was involved in endothelial senescence under diabetic conditions, and therapeutic targeting DDR1 would be exploited to inhibit endothelial senescence owing to high glucose exposure.PMID:34270989 | DOI:10.1016/j.ejphar.2021.174317
Source: European Journal of Pharmacology - July 16, 2021 Category: Drugs & Pharmacology Authors: Li Yan Xu Xie Bing-Xuan Niu Mei-Ting Wu Wei-Qiang Tong Shuang-Yi He Chu-Yi Huang Wei-Cheng Zhao Ge Li Nian-Sheng Li Jun-Lin Jiang Source Type: research

Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR- γ/PGC-1α Signaling Pathway
Conclusion: Diabetes mellitus induces adverse atrial structural, electrophysiological remodeling, and mitochondrial damage and dysfunction. Pioglitazone prevented these abnormalities through the PPAR-γ/PGC-1α pathway.
Source: Frontiers in Pharmacology - June 14, 2021 Category: Drugs & Pharmacology Source Type: research

Epac activation ameliorates tubulointerstitial inflammation in diabetic nephropathy
Acta Pharmacol Sin. 2021 Jun 8. doi: 10.1038/s41401-021-00689-2. Online ahead of print.ABSTRACTTubulointerstitial inflammation plays an important role in the progression of diabetic nephropathy (DN), and tubular epithelial cells (TECs) are crucial promoters of the inflammatory cascade. Exchange protein activated by cAMP (Epac) has been shown to suppress the angiotensin II (Ang-II)-induced release of inflammatory cytokines in tubular cells. However, the role of Epac in TEC-mediated tubulointerstitial inflammation in DN remains unknown. We found that administering the Epac agonist 8-pCPT-2'-O-Me-cAMP (8-O-cAMP) to db/db mice...
Source: Acta Pharmacologica Sinica - June 9, 2021 Category: Drugs & Pharmacology Authors: Wen-Xia Yang Yu Liu Shu-Min Zhang Hua-Fen Wang Yi-Fei Liu Jia-Lu Liu Xiao-Hui Li Meng-Ru Zeng Yu-Zhang Han Fu-You Liu Lin Sun Li Xiao Source Type: research

NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway
Diabetes increases the risk of stroke, exacerbates neurological deficits, and increases mortality. Non-mitogenic fibroblast growth factor 1 (nmFGF1) is a powerful neuroprotective factor that is also regarded as a metabolic regulator. The present study aimed to investigate the effect of nmFGF1 on the improvement of functional recovery in a mouse model of type 2 diabetic (T2D) stroke. We established a mouse model of T2D stroke by photothrombosis in mice that were fed a high-fat diet and injected with streptozotocin (STZ). We found that nmFGF1 reduced the size of the infarct and attenuated neurobehavioral deficits in our mous...
Source: Frontiers in Pharmacology - May 7, 2021 Category: Drugs & Pharmacology Source Type: research

Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: the role of omentin-1
CONCLUSIONS: Down-regulation of omentin-1 induces endothelial dysfunction and hypertension in obesity. TSG treatment (at least partially) increases omentin-1 via promoting binding of PPAR-γ and Itln-1 promoter in adipose tissues, subsequently exerts protective effects on endothelial function via activating Akt/eNOS/NO signaling and attenuating oxidative/nitrative stress. These results suggest that TSG could be developed as a promising anti-hypertension agent that protects against endothelial dysfunction and obesity-associated cardiovascular diseases.PMID:33647262 | DOI:10.1016/j.bcp.2021.114489
Source: Biochemical Pharmacology - March 1, 2021 Category: Drugs & Pharmacology Authors: Qianqian Dong Wenjuan Xing Kaifeng Li Xuanxuan Zhou Siwang Wang Haifeng Zhang Source Type: research

Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction
In conclusion, FYXN exerts a protective effect against DMCI by promoting angiogenesis via the Rab1/AT1R pathway, which provides strong evidence for the therapeutic effect of FYXN on DMCI.
Source: Frontiers in Pharmacology - February 17, 2021 Category: Drugs & Pharmacology Source Type: research

A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction.
Abstract Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients. HHcy induces endoplasmic reticulum (ER) stress and oxidative stress to impair endothelial function. The glucagon-like peptide 1 (GLP-1) analog exendin-4 attenuates endothelial ER stress, but the detailed vasoprotective mechanism remains elusive. The present study investigated the beneficial effects of exendin-4 against HHcy-induced endothelial dysfunction. Exendin-4 pretreatment reversed homocysteine-induced impairment of endothelium-dependent relaxations in C57BL/6 mo...
Source: Acta Pharmacologica Sinica - January 25, 2021 Category: Drugs & Pharmacology Authors: Cheng CK, Luo JY, Lau CW, Cho WC, Ng CF, Ma RCW, Tian XY, Huang Y Tags: Acta Pharmacol Sin Source Type: research

Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro
Conclusion: Empagliflozin improves hepatic steatosis through the AMPK-TET2-autophagy pathway. The use of empagliflozin as a treatment for preventing and treating MAFLD in patients with T2DM warrants further study.
Source: Frontiers in Pharmacology - January 20, 2021 Category: Drugs & Pharmacology Source Type: research

SGLT1 Inhibition Attenuates Apoptosis in Diabetic Cardiomyopathy via the JNK and p38 Pathway
Conclusion: SGLT1 can be used as a marker for the diagnosis of DCM, and SGLT1 inhibition can attenuate apoptosis, thereby suppressing DCM development via the JNK and p38 pathway.
Source: Frontiers in Pharmacology - January 12, 2021 Category: Drugs & Pharmacology Source Type: research

Metformin alleviates hydrogen peroxide-induced inflammation and oxidative stress via inhibiting P2X7R signaling in spinal cord tissue cells neurons.
In conclusion, our results show that metformin can alleviate H2O2-induced inflammation and oxidative stress via modulating the P2X7R signaling pathway. PMID: 33201730 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - November 17, 2020 Category: Drugs & Pharmacology Authors: Wang G, Chen S, Shao Z, Li Y, Wang W, Mao L, Li J, Mei X Tags: Can J Physiol Pharmacol Source Type: research