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Specialty: Molecular Biology
Condition: Diabetes
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Total 188 results found since Jan 2013.
Rosmarinic acid downregulates the oxLDL ‑induced interaction between monocytes and endothelial cells, in addition to monocyte diapedesis, under high glucose conditions
Int J Mol Med. 2022 May;49(5):68. doi: 10.3892/ijmm.2022.5125. Epub 2022 Mar 22.ABSTRACTEndothelial dysfunction during diabetes has been previously reported to be at least in part attributed to increased oxidized low‑density lipoprotein (oxLDL) levels mediated by high glucose (HG) levels. Endothelial inflammation increases the adhesiveness of monocytes to the endothelium in addition to increasing vascular permeability, promoting diabetic atherogenesis. In a previous study, it was reported that oxLDL treatment induced nucleotide‑binding domain and leucine‑rich repeat containing family, pyrin domain‑containing 3 infl...
Source: International Journal of Molecular Medicine - March 22, 2022 Category: Molecular Biology Authors: Jean Baptiste Nyandwi Young Shin Ko Hana Jin Seung Pil Yun Sang Won Park Kee Ryeon Kang Hye Jung Kim Source Type: research
α2-antiplasmin positively regulates endothelial-to-mesenchymal transition and fibrosis progression in diabetic nephropathy
CONCLUSIONS: The high glucose conditions induced α2AP production, and α2AP is associated with EndoMT and fibrosis progression in DN. These findings provide a basis for clinical strategies to improve DN.PMID:34709571 | DOI:10.1007/s11033-021-06859-z
Source: Molecular Biology Reports - October 28, 2021 Category: Molecular Biology Authors: Yosuke Kanno Momoko Hirota Osamu Matsuo Kei-Ichi Ozaki Source Type: research
Free fatty acid impairs myogenic differentiation through AMPK α-miR-206 pathway
Mol Cell Biol. 2021 Oct 25:MCB0032721. doi: 10.1128/MCB.00327-21. Online ahead of print.ABSTRACTThe activity of AMPKα is reduced in type-2 diabetes, and type-2 diabetes is associated with muscular atrophy. To date, there is little known about the mechanism by which FFA participates in muscular impairment. The purpose of the present study was to explore whether FFA damages myogenesis through AMPKα-HDAC4-miR-206 pathway. The results showed that 1mM FFA produced lipid accumulation, significantly impaired insulin signaling pathway and decreased myogenic differentiation of C2C12 myoblast cells. FFA reduced LKB1-AMPKα pathway...
Source: Mol Biol Cell - October 25, 2021 Category: Molecular Biology Authors: Aiwen Jiang Hongyun Guo Liangliang Zhang Xiaoyu Jiang Xiying Zhang Wangjun Wu Honglin Liu Source Type: research
Silencing of PFKFB3 protects podocytes against high glucose ‑induced injury by inducing autophagy
In conclusion, silencing of PFKFB3 may protect podocytes from HG‑induced injury by inducing autophagy. Therefore, PFKFB3 may serve as a potential target for treatment of DN.PMID:34490476 | DOI:10.3892/mmr.2021.12405
Source: Molecular Medicine Reports - September 7, 2021 Category: Molecular Biology Authors: Zhengming Zhu Qingsheng Liu Jianshi Sun Ziyang Bao Weiwei Wang Source Type: research
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK α/TGF-β/Smad signalling in type 2 diabetic rats
This study aimed to evaluate the effect of SGLT2 inhibitor dapagliflozin (DAPA) on DCM especially for cardiac fibrosis and explore the underlying mechanism. In vivo, the model of type 2 diabetic rats was built with high-fat feeding and streptozotocin injection. Untreated diabetic rats showed cardiac dysfunction, increased myocardial fibrosis and EndMT, which was attenuated after treatment with DAPA and metformin. In vitro, HUVECs and primary cardiac fibroblasts were treated with DAPA and exposed to high glucose (HG). HG-induced EndMT in HUVECs and collagen secretion of fibroblasts were markedly inhibited by DAPA. Up-regula...
Source: J Cell Mol Med - June 25, 2021 Category: Molecular Biology Authors: Jingjing Tian Mingjun Zhang Mengying Suo Dian Liu Xuyang Wang Ming Liu Jinyu Pan Tao Jin Fengshuang An Source Type: research
Tripterygium glycoside suppresses epithelial ‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway
Mol Med Rep. 2021 Aug;24(2):592. doi: 10.3892/mmr.2021.12231. Epub 2021 Jun 24.ABSTRACTTripterygium glycoside (TG) is a traditional Chinese medicine extract with immunosuppressive, anti‑inflammatory and anti‑renal fibrosis effects. Epithelial‑mesenchymal transition (EMT) and cell apoptosis are considered to be the major cause of podocyte injury in diabetic kidney disease (DKD). However, it remains unknown as to whether TG is able to alleviate podocyte injury to prevent DKD progression. Therefore, the present study aimed to clarify the podocyte protective effects of TG on DKD. TG, Twist1 small interfering RNA (siRNA) ...
Source: Molecular Medicine Reports - June 24, 2021 Category: Molecular Biology Authors: Mei Tao Danna Zheng Xudong Liang Diandian Wu Kang Hu Juan Jin Qiang He Source Type: research
