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Specialty: Cytology
Condition: Diabetes

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Total 94 results found since Jan 2013.

Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/ β-catenin signaling pathway
CONCLUSIONS: TSIIA was able to attenuate high glucose-induced EMT in HK2 cells by up-regulating VDR levels, which might be related to the inhibitory effect of VDR on the Wnt pathway.PMID:34852178 | DOI:10.5603/FHC.a2021.0025
Source: Folia Histochemica et Cytobiologica - December 1, 2021 Category: Cytology Authors: Jingyi Zeng Xiaorong Bao Source Type: research

Bradykinin Protects Human Endothelial Progenitor Cells from High-Glucose-Induced Senescence through B2 Receptor-Mediated Activation of the Akt/eNOS Signalling Pathway
CONCLUSION: BK, acting through PI3K-AKT-eNOS signalling pathways, reduced hTERT translocation, increased the relative length of telomeres while reducing mtDNA copy number, and finally protected against EPC senescence induced by HG.PMID:34557552 | PMC:PMC8452971 | DOI:10.1155/2021/6626627
Source: Cell Research - September 24, 2021 Category: Cytology Authors: Yuehuan Wu Cong Fu Bing Li Chang Liu Zhi He Xing-Er Li Ailing Wang Genshan Ma Yuyu Yao Source Type: research

Human umbilical cord mesenchymal stem cells reduce oxidative damage and apoptosis in diabetic nephropathy by activating Nrf2
CONCLUSIONS: hUCMSCs attenuated renal oxidative damage and apoptosis in type 2 diabetes mellitus and Nrf2 activation is one of the important mechanisms of this effect. hUCMSCs show potential as drug targets for DN.PMID:34380544 | DOI:10.1186/s13287-021-02447-x
Source: Cell Research - August 12, 2021 Category: Cytology Authors: Ping Nie Xue Bai Yan Lou Yuexin Zhu Shan Jiang Lina Zhang Na Tian Ping Luo Bing Li Source Type: research

Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca < sup > 2+ < /sup > -PPP3/calcineurin-TFEB axis
Autophagy. 2021 Aug 2:1-17. doi: 10.1080/15548627.2021.1956123. Online ahead of print.ABSTRACTMacroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (glucagon like peptide 1 receptor) agonist exendin-4 stimulates autophagic flux in a setting of chronic nutrient excess. The aim of this study was to identify the underlying pathways contributing to enhanced autophagic flux.Pancreatic β-cells (INS-1E),mouse and human islets were treated...
Source: Autophagy - August 2, 2021 Category: Cytology Authors: Francesco P Zummo Stanislaus I Krishnanda Merilin Georgiou Finbarr Pm O'Harte Vadivel Parthsarathy Kirsty S Cullen Minna Honkanen-Scott James Am Shaw Penny E Lovat Catherine Arden Source Type: research

Targeting TRAF3IP2 alleviates high glucose-induced cardiomyocyte inflammation and apoptosis
Drug Dev Res. 2021 Jul 14. doi: 10.1002/ddr.21856. Online ahead of print.ABSTRACTTo clarify the role of TRAF3IP2 in high glucose (HG)-stimulated cardiomyocyte inflammation and apoptosis and its action mechanism. SiRNA plasmid of TRAF3IP2 was constructed and transfected into HG-stimulated cardiomyocytes to silence TRAF3IP2. The expression of TRAF3IP2 was determined by quantitative polymerase chain reaction (qPCR) and western blot. Cell viability and cytotoxicity were first observed using cell counting kit-8 and lactate dehydrogenase assays. The inflammatory injury of the cardiomyocytes was then examined by real time-qPCR (R...
Source: Cell Research - July 14, 2021 Category: Cytology Authors: Jing Wei Tao Yan Yuanhong Liang Source Type: research

Gambogic acid ameliorates high glucose- and palmitic acid-induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo.
Abstract Diabetic retinopathy (DR) is a serious microvascular complication of diabetes. Gambogic acid has been reported to have anti-inflammatory effect. However, the effect of GA on inflammatory response of ARPE-19 cells remains unclear. In our study, ARPE-19 cells were stimulated by palmitic acid (PA) induction in the presence of 30 mM glucose and then treated with 0.5, 1, 2, 5, 10, or 20 μM GA. CCK-8 assay showed that cell viability was increased by GA treatment at doses of 0.5, 1, and 2 μM instead of higher doses. ELISA analysis found that GA dose-dependently reduced the production of pro-inflammatory med...
Source: Cell Stress and Chaperones - November 27, 2020 Category: Cytology Authors: Chen J, Li L, Zhou Y, Zhang J, Chen L Tags: Cell Stress Chaperones Source Type: research

SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy.
In conclusion, SMAD3 promotes lysosome depletion via the inhibition of TFEB-dependent lysosome biogenesis; this may be an important mechanism underlying autophagy dysregulation in the progression of diabetic nephropathy. Abbreviations: AGEs: advanced glycation end products; ATP6V1H: ATPase H+ transporting V1 subunit H; CTSB: cathepsin B; ChIP: chromatin immunoprecipitation; Co-BSA: control bovine serum albumin; DN: diabetic nephropathy; ELISA: enzyme-linked immunosorbent assay; FN1: fibronectin 1; HAVCR1/TIM1/KIM-1: hepatitis A virus cellular receptor 1; LAMP1: lysosomal associated membrane protein 1; LMP: lysosome membran...
Source: Autophagy - October 12, 2020 Category: Cytology Authors: Yang C, Chen XC, Li ZH, Wu HL, Jing KP, Huang XR, Ye L, Wei B, Lan HY, Liu HF Tags: Autophagy Source Type: research

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation.
Abstract Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4+ T cells from lean, normoglycemic older and younger subjects, and mimics a diabetes-associated Th17 profile. T cells from older compared to younger subjects also had defects in autophagy and mitochondrial bioenergetics that associate with redox imbalance. Metformin ameliorated the Th17 inflammaging profile by increasing autophagy and impr...
Source: Cell Metabolism - May 4, 2020 Category: Cytology Authors: Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Liu R, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Cui L, Proctor EA, Kern PA, Nikolajczyk BS Tags: Cell Metab Source Type: research

Dopamine 1 receptor activation protects mouse diabetic podocytes injury via regulating the PKA/NOX-5/p38  MAPK axis.
In conclusion, D1R activation can protect diabetic podocytes from apoptosis and oxidative damage, in part through the PKA/NOX-5/p38 MAPK pathway. PMID: 31954110 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - January 14, 2020 Category: Cytology Authors: Shao X, Zhang X, Hu J, Gao T, Chen J, Xu C, Wei C Tags: Exp Cell Res Source Type: research

Aerobic and resistance training enhances endothelial progenitor cell function via upregulation of caveolin-1 in mice with type 2 diabetes.
CONCLUSION: Combined AT and RT is an effective way to improve EPC function through upregulation of caveolin-1 in mice with type 2 diabetes. PMID: 31900223 [PubMed - in process]
Source: Cell Research - January 2, 2020 Category: Cytology Authors: Zhai L, Liu Y, Zhao W, Chen Q, Guo T, Wei W, Luo Z, Huang Y, Ma C, Huang F, Dai X Tags: Stem Cell Res Ther Source Type: research