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Neuromuscular and Muscle Metabolic Functions in MELAS Before and After Resistance Training: A Case Study
Conclusion To conclude, this study suggests a preserved plasticity in the skeletal muscle of a patient with MELAS. More importantly, Resistance Training appears to be a safe and effective method to increase skeletal muscle function in this patient population, and this effect is mediated by both neuromuscular and mitochondrial adaptations. However, particular attention and caution is needed in the interpretation of the data of this single case study and further studies are warranted including larger sample of patients. Ethics Statement For this case study the participant caregiver provided written informed consent. Auth...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Neuroimaging and Neurolaw: Drawing the Future of Aging
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, ...
Source: Frontiers in Endocrinology - April 7, 2019 Category: Endocrinology Source Type: research

Smoking and blood pressure: A complex relationship.
Abstract Hypertension and tobacco smoking are two major modifiable risk factors for atheromatous disease and its cardiovascular complications. If systolic hypertension (SBP≥140mmHg and DBP<90mmHg) is the leading risk factor for stroke, smoking (nicotine) has a more powerful impact on coronary events, aortic aneurysms, and peripheral artery disease. Smoking can transiently modify the regulation of blood pressure (BP) by a swift effect on the autonomic nervous system. It also accelerates arterial aging, which plays a role in chronic hypertension. Chronic sympathetic activation induced by tobacco smoking also ha...
Source: Presse Medicale - July 28, 2017 Category: General Medicine Authors: Madika AL, Mounier-Vehier C Tags: Presse Med Source Type: research

Device that measures cell strength could help identify drugs for asthma, hypertension and muscular dystrophy
Engineers, doctors and scientists at UCLA and Rutgers University have developed a tool that measures the physical strength of individual cells 100 times faster than current technologies.The new device could make it easier and faster to test and evaluate new drugs for diseases associated with abnormal levels of cell strength, including hypertension, asthma and muscular dystrophy. It could also open new avenues for biological research into cell force. It is the first high-throughput tool that can measure the strength of thousands of individual cells at a time.“Our tool tracks how much force individual cells exert over time...
Source: UCLA Newsroom: Health Sciences - February 9, 2018 Category: Universities & Medical Training Source Type: news

Congenital muscular dystrophies
To determine the minimal clinically important difference (MCID) for the motor function measure (MFM-32) in congenital muscular dystrophy and congenital myopathy patient an observational, retrospective, multicentric study was conducted on 85 congenital muscular dystrophy or congenital myopathy patients, aged 5 to 22 years at the national institute of neurological disorders and stroke of the national institutes of health and 2 French departments of paediatric physical medicine and rehabilitation. Data were collected if at least 2 MFMs were performed (MFM1 and MFM2) within 8 to 36 months of each other and if during MFM2 paren...
Source: Neuromuscular Disorders - September 6, 2018 Category: Neurology Authors: L. Le Goff, M. Fink, G. Norato, P. Rippert, K. Meilleur, A.R. Foley, M. Jain, M. Waite, S. Donkervoort, C. B önnemann, C. Vuillerot Source Type: research