Device that measures cell strength could help identify drugs for asthma, hypertension and muscular dystrophy

Engineers, doctors and scientists at UCLA and Rutgers University have developed a tool that measures the physical strength of individual cells 100 times faster than current technologies.The new device could make it easier and faster to test and evaluate new drugs for diseases associated with abnormal levels of cell strength, including hypertension, asthma and muscular dystrophy. It could also open new avenues for biological research into cell force. It is the first high-throughput tool that can measure the strength of thousands of individual cells at a time.“Our tool tracks how much force individual cells exert over time, and how they react when they are exposed to different compounds or drugs,” said Dino Di Carlo, professor of bioengineering at theUCLA Henry Samueli School of Engineering and Applied Science and the project ’s principal investigator. “It’s like a microscopic fitness test for cells with thousands of parallel stations.”The team ’s work is described in Nature Biomedical Engineering.Cells use physical force for essential biological functions — both as individual cells, for example in cell division or immune function, and as large groups of cells in tissue, for example, when muscles contract.  Disruptions in a cell ’s ability to control the levels of force they exert can lead to diseases or loss of important bodily functions. For example, asthma is caused by the smooth muscle cells that line the airways sq...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

Related Links:

Anuvinder Kaur, Muhammad Suleman Riaz, Shiv K. Singh, Uday Kishore
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Veronica Lazar, Lia-Mara Ditu, Gratiela Gradisteanu Pircalabioru, Irina Gheorghe, Carmen Curutiu, Alina Maria Holban, Ariana Picu, Laura Petcu, Mariana Carmen Chifiriuc
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study aims to evaluate the bioequivalence of two capecitabine formulations (150-mg tablet) using healthy male subjects under nonfasting conditions. The study was conducted as an open, randomized, three-period, semi-replicated design with three sequences (RRT, RTR, TRR) with a 1-week washout interval. The subjects were selected for the study after having their health status previously assessed by a clinical evaluation and laboratory tests (biochemical and hematological parameters, and urinalysis). A single capecitabine tablet (150 mg) was given in each occasion. Plasma capecitabine concentrations were analyzed by ...
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Publication date: Available online 15 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Angélica Torres-Berrio, Mauricio O. Nava-MesaAbstractCognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of posttraumatic stress disorder (PTSD) and Alzheimer’s disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypo...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Authors: Shibata N, Matsumoto K, Kitamura S, Sakashita A, Kizawa Y, Hirata KI Abstract A 67-year-old woman was admitted to our hospital due to an acute onset of consciousness disturbance, aphasia and left hemiplegia. Computed tomography revealed multiple systemic infarctions, including brain, kidney and spleen. Transesophageal echocardiography revealed vegetations attached to the mitral valve leaflets, which was suspected to be the embolic source. Repeated blood cultures were negative, and advanced lung cancer was incidentally revealed by computed tomography. She was then diagnosed with nonbacterial thrombotic endo...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion IgAVN in elderly patients is characterized by severe renal involvement. Elderly patients are at higher risk than adults for treatment-related adverse events. PMID: 30101942 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Kawase S, Matsumoto R, Imai S, Kawaguchi K, Hata Y, Horita N, Shiota Y Abstract We herein report a case of pulmonary hyalinizing granuloma (PHG), which is a rare pulmonary mass. A 69-year-old man with no symptoms presented to our hospital because of the appearance of an abnormal shadow on chest X-ray. Computed tomography revealed a right middle-lobe mass with spicula and infiltration into the upper lobe. Since a bronchofiberscopic examination showed no malignant cells in the specimen, the patient underwent thoracoscopic surgery, which revealed PHG. Spiculation and interlobar infiltration, which comprise th...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Ishii S, Tamiya A, Taniguchi Y, Tanaka T, Abe Y, Isa SI, Tsuyuguchi K, Suzuki K, Atagi S Abstract Nivolumab has become the standard second-line chemotherapy for non-small cell lung cancer. A 73-year-old man with stage IV non-small cell lung cancer received 6 cycles of chemotherapy with nab-paclitaxel/carboplatin/bevacizumab followed by 11 cycles of nab-paclitaxel/bevacizumab; however, treatment was stopped due to pneumothorax. One year after therapy started, a nodule appeared in the left upper lung and increased in size. Mycobacterium abscessus subsp. massiliense disease was diagnosed by a sputum analysis....
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Ogusu S, Takahashi K, Hirakawa H, Tanaka M, Komiya K, Nakamura T, Egashira R, Kai K, Takeda Y, Kimura S, Sueoka-Aragane N Abstract A 76-year-old asymptomatic man was found to have a mass in the right lower lung field. Although the presence of a mucinous component in the majority of the tumor was shown by magnetic resonance imaging, the presence of cancer cells was suspected by contrast enhancement on computed tomography (CT) and based on the partial accumulation in the marginal regions of the tumor on fluorodeoxyglucose-positron emission tomography (FDG-PET). A transbronchial lung biopsy was non-diagnostic...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Okuda Y, Yamada T, Ueda M, Ando Y Abstract Objective To clarify the underlying diseases, clinical manifestations, and treatment strategies for AA amyloidosis (AAA) in Japanese patients. Methods We conducted a survey on Japanese patients with AAA treated between January 1, 2012, and December 31, 2014. Results A total of 199 patients with AAA were included in the present study. The underlying diseases of AAA were rheumatoid arthritis (60.3%), uncharacterized inflammatory disorders (11.1%), neoplasms (7.0%), other rheumatic diseases (6.5%), inflammatory bowel diseases (4.5%), chronic infection (4.5%), Castlem...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
More News: Allergy & Immunology | Asthma | Biomedical Engineering | Calcium | Cancer | Cancer & Oncology | Cardiology | Computers | Contracts | Dermatology | Drugs & Pharmacology | France Health | Genetics | Headache | Heart | Heart Failure | Hypertension | Microbiology | Migraine | Molecular Biology | Muscular Dystrophy | Nanotechnology | National Institutes of Health (NIH) | Reflex Sympathetic Dystrophy | Science | Skin | Stroke | Study | Universities & Medical Training