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Device that measures cell strength could help identify drugs for asthma, hypertension and muscular dystrophy

Engineers, doctors and scientists at UCLA and Rutgers University have developed a tool that measures the physical strength of individual cells 100 times faster than current technologies.The new device could make it easier and faster to test and evaluate new drugs for diseases associated with abnormal levels of cell strength, including hypertension, asthma and muscular dystrophy. It could also open new avenues for biological research into cell force. It is the first high-throughput tool that can measure the strength of thousands of individual cells at a time.“Our tool tracks how much force individual cells exert over time, and how they react when they are exposed to different compounds or drugs,” said Dino Di Carlo, professor of bioengineering at theUCLA Henry Samueli School of Engineering and Applied Science and the project ’s principal investigator. “It’s like a microscopic fitness test for cells with thousands of parallel stations.”The team ’s work is described in Nature Biomedical Engineering.Cells use physical force for essential biological functions — both as individual cells, for example in cell division or immune function, and as large groups of cells in tissue, for example, when muscles contract.  Disruptions in a cell ’s ability to control the levels of force they exert can lead to diseases or loss of important bodily functions. For example, asthma is caused by the smooth muscle cells that line the airways sq...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Authors: Schuler PJ, von Witzleben A, Doescher J, Wollenberg B, Dietz A, Hoffmann TK Abstract In recent years, immunotherapy has been shown to be a promising approach for the treatment of various tumor entities. Due to further pharmacological developments and new studies, the checkpoint inhibitors have now arrived in the clinic. To date, patients with cancers in the head and neck region have benefited from these agents as part of a palliative therapy. Current clinical trials are testing other indications for the checkpoint inhibitors as monotherapy or in combination with other therapeutic approaches. The ...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
ConclusionsA small subset of pulmonary adenocarcinomas shows immunoreactivity for ER clones 6F11 and 1D5 in FNA samples (18.2% and 9.1%, respectively). The absence of immunoreactivity for ER‐SP1 clone indicates higher specificity of this clone in non‐breast tissue. The differential diagnostic value of all ER clones in malignant PEs appears to be secure. Larger studies are necessary to validate this observation.
Source: Diagnostic Cytopathology - Category: Pathology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Mari Lopez, who ran the food channel at home in Houston, Texas with her niece Liz Johnson, told viewers she had rejected traditional treatment for breast cancer in favor of a 90-day juice cleanse.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We describe a young woman with typical IIH who underwent lumbar puncture and was treated with a short course of high-dose corticosteroids followed by acetazolamide. She subsequently developed CVST, subarachnoid hemorrhage, and stroke. Risk factors that may have resulted in CVST are discussed.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Clinical Observation Source Type: research
We describe a patient with a giant pituitary adenoma who developed pendular seesaw nystagmus. Disturbance in the visuovestibular system is postulated to contribute to this form of seesaw nystagmus. Lesions compressing the optic chiasm and the accessory optic system could interrupt the transmission of retinal error signals to the inferior olivary nucleus and the interstitial nucleus of Cajal, thus interfering with the adaptive mechanism of the vestibulo-ocular reflex and leading to pendular seesaw nystagmus.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Clinical Observation Source Type: research
Abstract: A 5-year-old boy had initial symptoms of behavioral changes, nausea, vomiting, headache, weight loss, and progressive vision failure. Brain MRI revealed abnormal signal intensity in both optic nerves, the optic chiasm, the right medial temporal lobe, and tissues surrounding the right supraclinoid internal carotid artery with associated leptomeningeal and spinal cord enhancement. After nondiagnostic dural and spinal arachnoid biopsies, a temporal lobe biopsy was diagnostic for a rare malignant peripheral nerve sheath tumor.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Clinical-Pathological Case Study Source Type: research
No abstract available
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Letters to the Editor Source Type: research
No abstract available
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Letters to the Editor Source Type: research
Conclusions: This case illustrates that bilateral vision loss and chronic headaches in patients with GCA may result from retina-directed autoimmunity and pachymeningitis.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
We describe a 68-year-old diabetic woman with disabling paroxysmal positioning upbeat nystagmus (UBN) exclusively in the supine position, associated with asymptomatic spontaneous DBN, alternating skew deviation and hyperactive vestibulo-ocular reflex responses on head impulse testing, in whom high titers of anti-GAD antibodies were detected. After treatment with intravenous immunoglobulin, a complete resolution of positioning UBN and spontaneous DBN occurred, along with a decrease in anti-GAD antibody titers. Positioning UBN in this case may reflect a transient disinhibition of the central vestibular pathways carrying post...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
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