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Thromboembolic complications of recreational nitrous oxide (ab)use: a systematic review
We report on the thromboembolic complications, a less known side effect, associated with recreational inhalation of nitrous oxide. An extensive literature search was performed for publications reporting on the thromboembolic complications associated with recreational nitrous oxide abuse. Data about sex, age, location of thrombosis, laboratory findings, therapy and outcome were collected. A total of 13 case reports or case series were identified comprising a total of 14 patients. The reported thromboembolic side effects included deep venous thrombosis, pulmonary embolism, mesenterial-, portal and splenic vein thrombosis, ce...
Source: Journal of Thrombosis and Thrombolysis - June 27, 2022 Category: Hematology Source Type: research

Risk Factors for Major Adverse Cardiovascular Events and Major Adverse Limb Events after Venous Thromboembolism: A Large Prospective Cohort Study
Conclusions Risk factors for MACE and MALE after VTE included some traditional cardiovascular risk factors, patient's comorbidities, and some characteristics of VTE. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Thrombosis and Hemostasis - June 30, 2022 Category: Hematology Authors: Noumegni, Steve Raoul Didier, Romain Mansourati, Vincent Moigne, Emmanuelle Le Mao, Raphael Le Hoffmann, Cl ément Moreuil, Claire De Tromeur, C écile Roux, Pierre-Yves Le Nasr, Bahaa Gentric, Jean-Christophe Guegan, Marie Poulhazan, Elise Lacut, Karine Tags: Review Article Source Type: research

Genome- and transcriptome-wide association studies show that pulmonary embolism is associated with bone-forming proteins
Expert Rev Hematol. 2022 Jul 18. doi: 10.1080/17474086.2022.2103534. Online ahead of print.ABSTRACTBACKGROUND: Pulmonary embolism (PE) is a leading cause of death in stroke patients and a severe health burden worldwide. There is a pressing need to understand the mechanisms by which it occurs and to identify at-risk patients efficiently and accurately.OBJECTIVES: The aim of this paper was to analyze the genetic correlation between PE and human plasma proteins through genome-wide association study (GWAS) with transcriptome-wide association study (TWAS), in combination with mRNA expression profiling at three levels: DNA, RNA,...
Source: Expert Review of Hematology - July 18, 2022 Category: Hematology Authors: Ruoyang Feng Mengnan Lu Yanni Yang Pan Luo Lin Liu Ke Xu Peng Xu Source Type: research

NO/cGMP/PKG pathway in platelets:the therapeutic potential of PDE5 inhibitors in platelet disorders
J Thromb Haemost. 2022 Aug 11. doi: 10.1111/jth.15844. Online ahead of print.ABSTRACTPlatelets are the "guardians" of the blood circulatory system. At sites of vessel injury, they ensure hemostasis and promote immunity and vessel repair. However, their uncontrolled activation is one of the main drivers of thrombosis. To keep circulating platelets in a quiescent state, the endothelium releases platelet antagonists including nitric oxide (NO) that acts by stimulating the intracellular receptor guanylyl cyclase (GC). The latter produces the second messenger cyclic guanosine-3',5'-monophosphate (cGMP) that inhibits platelet ac...
Source: Thrombosis and Haemostasis - August 11, 2022 Category: Hematology Authors: Anisa Degjoni Federica Campolo Lucia Stefanini Mary Anna Venneri Source Type: research

Factor eight inhibiting bypass activity for refractory bleeding in acute type A aortic dissection repair: A propensity-matched analysis
We report our experience in utilizing FEIBA in ATAAD repair.STUDY DESIGN AND METHODS: A retrospective review was undertaken of all consecutive patients who underwent repair of ATAAD between July 2014 and December 2019. Patients were divided into two groups, dependent upon whether or not they received FEIBA intraoperatively: "FEIBA" (n = 112) versus "no FEIBA" (n = 119). From this, 53 propensity-matched pairs of patients were analyzed with respect to transfusion requirements and short-term clinical outcomes.RESULTS: Thirty-day mortality for the entire cohort was 11.7% (27 deaths), not significantly different between patient...
Source: Transfusion - September 21, 2022 Category: Hematology Authors: Stevan S Pupovac Randy Levine Ashley T Giammarino Samuel Jacob Scheinerman Alan R Hartman Derek R Brinster Jonathan M Hemli Source Type: research

Independent risk factors for an increased incidence of thromboembolism after lung transplantation
ConclusionsThe incidence of TE after LTX is high, especially in lung transplant recipients with a BMI  >  25 and an age >  55 years as well as cardiovascular risk factors closely associated with the metabolic syndrome. As these patients comprise a growing recipient fraction, intensified research should focus on the risks and benefits of regular screening or a prolonged TE prophylaxis in these patients.Trial registration number DKRS: 00021501.
Source: Journal of Thrombosis and Thrombolysis - December 10, 2022 Category: Hematology Source Type: research

Recurrent thrombotic events after disappearance of antiphospholipid autoantibodies: A long-term longitudinal study in patients with antiphospholipid syndrome
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of thrombosis and/or pregnancy morbidity related to the presence of persistent antiphospholipid autoantibodies (aPL) [1]. The most frequent clinical manifestations of APS are thrombotic events and death may be caused by stroke, myocardial infarction, pulmonary embolism or catastrophic APS [2]. APS treatment is based on long term anticoagulation [3].
Source: Thrombosis Research - February 9, 2023 Category: Hematology Authors: Thomas Ballul, Arthur Mageau, Pascale Roland Nicaise, Nadine Ajzenberg, Andrey Strukov, Antoine Dossier, Diane Rouzaud, Thomas Papo, Karim Sacr é Tags: Letter to the Editors-in-Chief Source Type: research

Hypercoagulability evaluation in congenital red blood cell disorders using thrombin generation assay
Congenital red blood cell (RBC) disorders are common diseases in the general population. The main outcomes are increased deformability due to erythrocyte instability, increased susceptibility to oxidative stress, and intravascular hemolysis. Hemolytic anemia is associated with thrombosis risk [1]. Main mechanisms are related to hypercoagulability, endothelial damage, altered blood flow, and decreased nitric oxide. Hypercoagulability is well documented in sickle cell disease (SCD) [2]. However, other RBC disorders are associated with pulmonary embolism, hypertension, non-ischemic stroke, and adverse vascular manifestations ...
Source: Thrombosis Research - March 23, 2023 Category: Hematology Authors: Guillaume Feugray, Maximilien Grall, C écile Dumesnil, Ygal Benhamou, Valery Brunel, Véronique Le Cam Duchez, Agnès Lahary, Paul Billoir Tags: Letter to the Editors-in-Chief Source Type: research

Thrombosis and bleeding in patients with COVID-19 requiring extracorporeal membrane oxygenation: a systematic review and meta-analysis
CONCLUSIONS: Circuit thrombosis and major bleeding were the most common thrombotic and bleeding events. The incidence of ICH was significantly higher when ECMO was indicated for COVID-19 than for other respiratory diseases. There is no evidence for stronger anticoagulation practice, and remains no consistent anticoagulation strategy to reduce the occurrence of thrombosis and bleeding under the double "hit" of COVID-19 and ECMO.PMID:36999123 | PMC:PMC9993729 | DOI:10.1016/j.rpth.2023.100103
Source: Thrombosis and Haemostasis - March 31, 2023 Category: Hematology Authors: Yu Jin Yang Zhang Jinping Liu Zhou Zhou Source Type: research

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