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Effect of aqueous olanexidine versus alcohol-based chlorhexidine for surgical skin antisepsis on incidence of surgical site infections in gastrointestinal surgery: multicentre randomised controlled clinical trial (OEDO trial) protocol
Introduction Surgical site infections (SSIs) are among the most common nosocomial infections in surgery patients. Two types of preparations, povidone-iodine and chlorhexidine-alcohol, are commonly used in preoperative antiseptic procedures worldwide. However, there are inconsistencies among international guideline recommendations concerning skin antiseptics. This trial aimed to evaluate the superiority of olanexidine, which reduced SSI rates more than povidone-iodine in our previous randomised trial, over chlorhexidine-alcohol in clean-contaminated surgery. Methods and analysis This multicentre randomised controlled clini...
Source: BMJ Open - August 21, 2023 Category: General Medicine Authors: Takeuchi, M., Obara, H., Furube, T., Kawakubo, H., Kitago, M., Okabayashi, K., Aoyama, J., Amemiya, R., Fujisaki, H., Sano, J., Goto, R., Sato, Y., Kitagawa, Y. Tags: Open access, Surgery Source Type: research

Patch Testing to Chlorhexidine Digluconate, 1% Aqueous: North American Contact Dermatitis Group Experience, 2015-2020
Conclusions: Chlorhexidine digluconate allergy is uncommon, but often clinically relevant. Involvement of the hands, face, and scattered generalized patterns was frequent. Occupationally related reactions were found predominantly in health care workers.PMID:37279017 | DOI:10.1089/derm.2023.0077
Source: Dermatitis - June 6, 2023 Category: Dermatology Authors: Erin M Warshaw Joohee Han Sara A Kullberg Joel G DeKoven Brandon L Adler Jonathan I Silverberg Marie-Claude Houle Melanie D Pratt Donald V Belsito Jiade Yu Nina C Botto Margo J Reeder James S Taylor Amber R Atwater Cory A Dunnick Vincent A DeLeo Chris M M Source Type: research

Stability of dexamethasone sodium phosphate over a 28  day period when added to commercial veterinary wipe and pad products
Conclusions and clinical importance - These data provide evidence that Dex SP is stable for 28 days in TCL and KH, and not in DCP from D0 to D14 or D28 days.PMID:35859527 | DOI:10.1111/vde.13108
Source: Veterinary Dermatology - July 21, 2022 Category: Veterinary Research Authors: Sara Bancroft Nicole Heinrich Mike McGilliard Source Type: research

Health care worker sensitivity to chlorhexidine-based hand hygiene solutions: A cross-sectional survey
ConclusionsScreening programs need to identify nurses who develop chlorhexidine sensitivity due to occupational exposure. Strategies to mitigate risk should provide alternatives for those with sensitization.
Source: American Journal of Infection Control - February 12, 2019 Category: Infectious Diseases Source Type: research

Prospective Single-Center Observational Study of the Allergenic Potential of Mercromina Film and Other Common Antiseptics in Patients With Contact Dermatitis
Conclusions Based on the patch tests conducted, Mercromina Film has very low allergenic potential. The highest allergenic potential was observed for povidone-iodine.
Source: Actas Dermo-Sifiliograficas - November 27, 2017 Category: Dermatology Source Type: research

Prospective Single-Center Observational Study of the Allergenic Potential of Mercromina Film and Other Common Antiseptics in Patients With Contact Dermatitis.
CONCLUSIONS: Based on the patch tests conducted, Mercromina Film has very low allergenic potential. The highest allergenic potential was observed for povidone-iodine. PMID: 28969846 [PubMed - as supplied by publisher]
Source: Actas Dermo-Sifiliograficas - September 29, 2017 Category: Dermatology Authors: Baltà Cruz S, Moreno Ribera N, Estrach Panella MT Tags: Actas Dermosifiliogr Source Type: research

Chronic Allergic Contact Dermatitis Due to Chlorhexidine
Publication date: Available online 19 September 2017 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Timothy J. Watts, Philip H. Li, Kok Loong Ue, Rubaiyat Haque
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 20, 2017 Category: Allergy & Immunology Source Type: research

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