• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Case Report: Digital Ulcers & Weight Loss in a Pediatric Patient
Juvenile dermatomyositis (JDM) is a childhood form of inflammatory myopathy affecting children younger than 18 years. The diagnosis of JDM is based on characteristic clinical features of proximal muscle weakness, skin rash, elevated muscle enzymes, magnetic resonance imaging and muscle biopsy.1 Autoantibodies seen in patients with inflammatory myopathy are not only associated with particular phenotypes... [Read More]
Source: The Rheumatologist - June 13, 2021 Category: Rheumatology Authors: Anusha Vuppala, MD, & Sarwat Umer, MD Tags: Conditions interstitial lung disease (ILD) juvenile dermatomyositis Pediatric Source Type: research

Dropped Head Syndrome and the Presence of Rimmed Vacuoles in a Muscle Biopsy in Scleroderma-Polymyositis Overlap Syndrome Associated with Anti-Ku Antibody.
Authors: Takeshi Y, Mai Y, Kinjo M, Manabu J, Itsuro H Abstract A 66-year-old woman with a history of interstitial lung disease presented with a 3-month history of dropped head syndrome (DHS), followed by camptocormia and extremity weakness. A clinical examination revealed Raynaud phenomenon, arthralgia, distal skin sclerosis, and microbleeds in the nailfold capillaries. An anti-Ku antibody test was positive. A muscle biopsy revealed inflammatory myopathy with rimmed vacuoles (RVs). The diagnosis of scleroderma-polymyositis (SSc-PM) overlap syndrome was made. RVs on a muscle biopsy in a patient with inflammatory my...
Source: Internal Medicine - November 21, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Pulmonary Pathologic Manifestations of Anti-Alanyl-tRNA Synthetase (Anti-PL-12)-Related Inflammatory Myopathy.
CONCLUSIONS: - Lung disease is often the first manifestation of anti-PL-12 ARS. There are no pathognomonic histopathologic features to distinguish anti-PL-12 ARS-related lung disease from idiopathic variants of diffuse interstitial lung disease. Increased inflammation, lymphoid aggregates, and nonspecific interstitial pneumonia-like areas in a biopsy, as well as clinical features of mechanic's hands, Raynaud phenomenon, arthritis, and fever, should prompt pathologists to suggest involvement by ARS. PMID: 28967806 [PubMed - as supplied by publisher]
Source: Archives of Pathology and Laboratory Medicine - October 2, 2017 Category: Laboratory Medicine Authors: Schneider F, Yousem SA, Oddis CV, Aggarwal R Tags: Arch Pathol Lab Med Source Type: research

Clinical Dermatomyositis Associated with Anti-HMG-CoA Reductase Antibody Positive Immune Mediated Necrotizing Myopathy: A Case Report (P2.125)
Conclusions:Statins have been previously linked to clinical dermatomyositis. Here we report the first known case of anti-HMGCR antibody confirmed immune mediated necrotizing myopathy with clinical features of dermatomyositis, yet pathologic findings consistent with necrotizing myopathy.Disclosure: Dr. Lavian has nothing to disclose. Dr. Mozaffar has received personal compensation for activities with Sanofi Genzyme, Grifols, Amicus, Biomarin, Idera Pharmaceuticals and Ultragenyx. Dr. Mozaffar has received research support from Cytokinetics, Alexion, Amicus, Biomarin, Grifols, GlaxoSmithKline, Ultragenyx, and Novartis. Dr. G...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lavian, M., Mozaffar, T., Goyal, N. Tags: Myopathies & amp;amp; Myasthenia Gravis II Source Type: research

Focal and Patchy Perifasicular Involvement Differentiates the Anti-Jo1 Inflammatory Myopathy (IM) from Dermatomyositis (DM) (P3.125)
Conclusions: Perimysial fragmentation and necrotizing perifascicular myositis are features that have been described by others to differentiate anti-jo1 IM form DM. In addition we found that the changes in muscle biopsies of patients with Jo1-IM are focal and patchy (affect some fibers, where others are spared at the same level) and tend to affect the most superficial layers of the fascicles. Muscle fiber necrosis and regeneration is seen in acute stages, while muscle fiber atrophy develop later in the course of the disease. This pattern of perifascicular involvement can help differentiate anti-jo1 IM from DM. Disclosure: D...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Chahin, N., Karam, C. Tags: Acquired Muscle Disorders: Clinical and Pathological Aspects Source Type: research

Meeting the challenges in the diagnosis of inflammatory myopathies.
Authors: Manie M Abstract Inflammatory myopathy (IM) is a rubric term to describe a heterogeneous group of muscle diseases typified by dermatomyositis and polymyositis. The current classifications are unsatisfactory, but IM associated with other connective tissue diseases (CTDs), such as systemic lupus erythematosus, underlying malignancy and HIV, should also be included. Although uncommon, IM should always be considered in a patient who presents with proximal weakness of gradual onset and has raised serum muscle enzymes. The diagnosis may be obvious if the patient has diagnostic skin signs such as heliotropic rash...
Source: South African Medical Journal - March 6, 2016 Category: African Health Tags: S Afr Med J Source Type: research

Pulmonary pathologic manifestations of anti-glycyl-tRNA synthetase (anti-EJ)-related inflammatory myopathy
Conclusions Identifying ARS-associated autoantibodies in ILD patients with or without myopathy is desirable because patients may respond well to immunosuppressive therapy, and their prognosis is better than that of patients with idiopathic forms of DAD or UIP.
Source: Journal of Clinical Pathology - July 16, 2014 Category: Pathology Authors: Schneider, F., Yousem, S. A., Bi, D., Gibson, K. F., Oddis, C. V., Aggarwal, R. Tags: Immunology (including allergy), Muscle disease, Inflammation, Interstitial lung disease, Degenerative joint disease, Musculoskeletal syndromes, Clinical diagnostic tests Original article Source Type: research