Focal and Patchy Perifasicular Involvement Differentiates the Anti-Jo1 Inflammatory Myopathy (IM) from Dermatomyositis (DM) (P3.125)

Conclusions: Perimysial fragmentation and necrotizing perifascicular myositis are features that have been described by others to differentiate anti-jo1 IM form DM. In addition we found that the changes in muscle biopsies of patients with Jo1-IM are focal and patchy (affect some fibers, where others are spared at the same level) and tend to affect the most superficial layers of the fascicles. Muscle fiber necrosis and regeneration is seen in acute stages, while muscle fiber atrophy develop later in the course of the disease. This pattern of perifascicular involvement can help differentiate anti-jo1 IM from DM. Disclosure: Dr. Chahin has nothing to disclose. Dr. Karam has received personal compensation in an editorial capacity for WriteClick.
Source: Neurology - Category: Neurology Authors: Tags: Acquired Muscle Disorders: Clinical and Pathological Aspects Source Type: research