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NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses
The objective of this study was to explore the role of NOD2 and TLR2 in cross-presentation in human dendritic cells undertaking an unbiased screen. We have used a quantitative phosphoproteomic analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) followed by a computational analysis to identify the proteins as differentially abundant in response to NOD2 and TLR2 sensing. Validation of the phosphoproteomic analysis was performed by the detection of proteins in phosphoenriched lysates and detected by western blot. Techniques for the modulation of gene expression (shRNA and siRNA) were used to confirm the resu...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Expression of human REG family genes in inflammatory bowel disease and their molecular mechanism
AbstractThe pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn ’s disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. However, expression of all theREG family genes in IBD is still unclear. Here, we analyzed expression of all theREG family genes (REGI α,REGI β,REG III,HIP/PAP, andREG IV) in biopsy specimens of UC and CD by real-time RT-PCR.REG I α,REG I β, andREG IV genes were overexpressed in CD samples.REG IV ge...
Source: Immunologic Research - January 29, 2019 Category: Allergy & Immunology Source Type: research

Expression of Human Cathelicidin Peptide LL-37 in Inflammatory Bowel Disease.
This article is protected by copyright. All rights reserved. PMID: 28872665 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - September 5, 2017 Category: Allergy & Immunology Authors: Kusaka S, Nishida A, Takahashi K, Bamba S, Yasui H, Kawahara M, Inatomi O, Sugimoto M, Andoh A Tags: Clin Exp Immunol Source Type: research

Expression of Human Cathelicidin Peptide LL ‐37 in Inflammatory Bowel Disease
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Immunology - September 1, 2017 Category: Allergy & Immunology Authors: Shoko Kusaka, Atsushi Nishida, Kenichiro Takahashi, Shigeki Bamba, Hiroyuki Yasui, Masahiro Kawahara, Osamu Inatomi, Mitsushige Sugimoto, Akira Andoh Tags: Original Article Source Type: research

Disruption of macrophage pro-inflammatory cytokine release in Crohn's disease is associated with reduced optineurin expression in a subset of patients.
This article is protected by copyright. All rights reserved. PMID: 24943399 [PubMed - as supplied by publisher]
Source: Immunology - June 18, 2014 Category: Allergy & Immunology Authors: Smith A, Sewell G, Levine A, Chew T, Dunne J, O'Shea N, Smith P, Harrison P, Macdonald C, Bloom S, Segal A Tags: Immunology Source Type: research