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Specialty: Molecular Biology
Condition: Staphylococcus Aureus
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Total 1130 results found since Jan 2013.
Chlorogenic acid enhances PPAR γ-mediated lipogenesis through preventing Lipin 1 nuclear translocation in Staphylococcus aureus-exposed bovine mammary epithelial cells
In this study, the internalization of S. aureus reduced intracellular lipid droplet formation, decreased the levels of intracellular triacylglycerol, total cholesterol and 7 types of fatty acid and downregulated the expression of lipogenic genes FAS, ACC, and DGAT1 in bovine mammary epithelial cells (BMECs). In addition, we found that S. aureus intracellular infection attenuated mTORC1 activation resulting in Lipin 1 nuclear localization. Remarkablely, S. aureus infection-mediated repression of lipid synthesis related to the mTORC1 signaling and Lipin 1 nuclear localization can be alleviated by CGA. Thus, our findings prov...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Ruiyuan Yao Manshulin Wang Yue Zhao Qiang Ji Xue Feng Linfeng Bai Lili Bao Yanfeng Wang Huifang Hao Xihe Li Zhigang Wang Source Type: research
Vaginal Microbiota Profile in first-trimester miscarriages cases
In this study, 435 vaginal swabs were collected from aborted women in Maternity Teaching Hospitals in Erbil and Shahid Dr. Khalid Hospital in Koya. We characterized the vaginal microbiota diversity and composition in first-trimester abortion and investigated the association between bacterial vaginosis and abortion before 12 weeks. Cultural, morphological, and biochemical characteristics for each bacterial genus were discovered, and VITEK-2 system was used to identify isolated bacteria. Samples from each type of bacteria were selected for sequencing utilizing 16 rRNA genes examining V4-V8 region for bacterial profiles. Bact...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Saman Rafeeq Abdulla Sarmad Raheem Kareem Ayad H Hasan Source Type: research
Design, synthesis, biological evaluation and molecular docking study of novel pleuromutilin derivatives containing substituted benzoxazole as antibacterial agents
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2251712. doi: 10.1080/14756366.2023.2251712.ABSTRACTA series of pleuromutilin analogs containing substituted benzoxazole were designed, synthesised, and assessed for their antibacterial activity both in vivo and in vitro. The MIC of the synthesised derivatives was initially assessed using the broth dilution method against four strains of Staphylococcus aureus (MRSA ATCC 43300, S. aureus ATCC 29213, clinical isolation of S. aureus AD3 and S. aureus 144). Most of the synthesised derivatives displayed prominent in vitro activity (MIC ≤ 0.5 µg/mL). Compounds 50 and 57 exhibited the mo...
Source: Molecular Medicine - September 4, 2023 Category: Molecular Biology Authors: Jie Ren Qi-Wen Zhang Xian-Jin He Xiao-Ying Chen Zi-Dan Zhou Zhen-Ling Zeng Zhen Jin You-Zhi Tang Source Type: research
Discovery and biological evaluation of pregnenolone selenocyanoamides with potential anticancer and antimicrobial activities
J Steroid Biochem Mol Biol. 2023 Aug 29:106388. doi: 10.1016/j.jsbmb.2023.106388. Online ahead of print.ABSTRACTStarting with pregnenolone, a 20-carbonyl group was converted into an amino group through a series of chemical reactions. This amino group was further converted into selenocyanoalkylamide, leading to the synthesis of six pregnenolone selenocyanoalkylamide derivatives. These compounds were then screened for antitumor activity in vitro, yielding promising results. Compounds 4b-4f show higher inhibitory activity than the positive control abiraterone and 2-methoxyestradiol, with IC50 values lower than 10 μmol/L agai...
Source: Mol Biol Cell - August 31, 2023 Category: Molecular Biology Authors: Yanmin Huang Wenhao Tian Zining Peng Yang Cheng Meizhen Wei Zhiping Liu Liping Pang Jianguo Cui Source Type: research
Saikosaponin A alleviates Staphylococcus aureus-induced mastitis in mice by inhibiting ferroptosis via SIRT1/Nrf2 pathway
In conclusion, SAA protected S. aureus-induced mastitis through suppressing inflammation and ferroptosis by activating SIRT1/Nrf2 pathway.PMID:37644785 | DOI:10.1111/jcmm.17914
Source: J Cell Mol Med - August 30, 2023 Category: Molecular Biology Authors: Lihua Zhao Lei Jin Bin Yang Source Type: research
Molecular identification and biofilm formation of aerobic and anaerobic coinfection bacterial isolated from cystic fibrosis patients in southwest Iran from 2014 to 2022
CONCLUSION: In conclusion, P. aeruginosa was found to be the most frequently isolated bacterium from patients with CF, and many of these bacteria could form biofilms. Additionally, the high prevalence of antibiotic resistance indicates the urgent need for increased attention to antibiotic preparation and patient screening concerning bacterial coinfections and the virulence and adhesion factors of these bacteria. Furthermore, the present study demonstrates that the coinfection of bacteria with high antibiotic resistance and a high capacity for biofilm formation can pose a life-threatening risk to CF patients, mainly due to ...
Source: Molecular Biology Reports - August 11, 2023 Category: Molecular Biology Authors: Sasan Moogahi Fateme Tadi Beni Mohammad Hashemzadeh Aram Asareh Zadegan Dezfuli Source Type: research
Antibacterial activity of Lagerstreomia speciosa and its active compound, corosolic acid, enhances cefotaxime inhibitory activity against Staphylococcus aureus
CONCLUSIONS: L. speciosa leaves and bark extract and its active compound, corosolic acid, could be used as a potential anti-Staphylococcus aureus treatment to enhance the therapeutic use of cefotaxime.PMID:37541956 | DOI:10.1093/jambio/lxad171
Source: Mol Biol Cell - August 4, 2023 Category: Molecular Biology Authors: Sylvia Sinelius Jullietta Lady Michellina Yunardy Enty Tjoa Agustina D R Nurcahyanti Source Type: research
Thermal susceptibility and antibiotic synergism of methicillin-resistant < em > Staphylococcus aureus < /em > biofilms
This study investigated the thermal susceptibility of MRSA biofilms to thermal shocks from 60 to 80 °C for 1-30 min as well as the effect of various antibiotics (most notably methicillin) on thermal mitigation. Pre- and post-shock exposure to three different classes of antibiotics (ciprofloxacin, tobramycin, and methicillin) at concentrations ranging from 0.25 to 128 μg mL-1 were investigated. MRSA biofilms exhibited thermal susceptibility comparable to other common nosocomial pathogens, such as Pseudomonas aeruginosa, though with greater variability. Exposure to antibiotics of any class significantly decreased the degre...
Source: Biofouling - July 24, 2023 Category: Molecular Biology Authors: Haydar A S Aljaafari Parham Parnian Jaymes Van Dyne Eric Nuxoll Source Type: research
