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Condition: Obesity
Drug: Estradiol
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Total 177 results found since Jan 2013.
Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation
Biol Reprod. 2023 Sep 2:ioad108. doi: 10.1093/biolre/ioad108. Online ahead of print.ABSTRACTSpexin (SPX) is a novel neuropeptide and adipokine negatively correlated with obesity and insulin resistance. A recent study investigated expression and regulatory function of SPX in the hypothalamus and pituitary; however, the effect on ovarian function is still unknown. The aim of this study was to characterize the expression of SPX and its receptors, galanin receptors 2 and 3 (GALR2/3) in the human ovary and to study its in vitro effect on granulosa cells (GC) function. Follicular fluid (FF) and GC were obtained from normal weigh...
Source: Reproductive Biology - September 2, 2023 Category: Reproduction Medicine Authors: Patrycja Kurowska Monika Dawid Julia Oprocha Natalia Repekta Lo ïse Serra Anthony Estienne Piotr Pawlicki Ma łgorzata Kotula-Balak Fabrice Gu érif Joelle Dupont Agnieszka Rak Source Type: research
Factors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses
CONCLUSION: Multiple factors are associated with variation in male testosterone, SHBG, and LH concentrations. Reduced testosterone and increased LH concentrations may indicate impaired testicular function after age 70 years. Interpretation of individual testosterone measurements should account particularly for age older than 70 years, obesity, diabetes, and cancer.PRIMARY FUNDING SOURCE: Medical Research Future Fund, Government of Western Australia, and Lawley Pharmaceuticals. (PROSPERO: CRD42019139668).PMID:37639720 | DOI:10.7326/M23-0342
Source: Annals of Internal Medicine - August 28, 2023 Category: Internal Medicine Authors: Ross J Marriott Kevin Murray Robert J Adams Leen Antonio Christie M Ballantyne Douglas C Bauer Shalender Bhasin Mary L Biggs Peggy M Cawthon David J Couper Adrian S Dobs Leon Flicker David J Handelsman Graeme J Hankey Anke Hannemann Robin Haring Benjumin Source Type: research
Accelerated bone loss in older men with severe abdominal aortic calcification - the prospective MINOS study
CONCLUSIONS: Severe AAC is associated with faster bone loss in older men and may contribute to the higher fracture risk observed in this population.PMID:37610245 | DOI:10.1210/clinem/dgad459
Source: The Journal of Clinical Endocrinology and Metabolism - August 23, 2023 Category: Endocrinology Authors: Pawel Szulc Joshua R Lewis Roland Chapurlat Source Type: research
FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer
CONCLUSIONS: Collectively, our data suggest that one mechanism by which obesity and weight gain promote breast cancer progression is through estrogen-independent ER activation and cancer cell metabolic reprogramming, partly driven by FGF/FGFR. The first-line treatment for many patients with ER-positive breast cancer is inhibition of estrogen synthesis using aromatase inhibitors. In women with obesity who are experiencing weight gain, locally produced FGF1 may activate ER to promote cancer cell metabolic reprogramming and tumor progression independently of estrogen.PMID:37608351 | DOI:10.1186/s13058-023-01699-0
Source: Cell Research - August 23, 2023 Category: Cytology Authors: Marisol Castillo-Castrejon Barbara Mensah Sankofi Stevi Johnson Murguia Abasi-Ama Udeme Hoaning Howard Cen Yi Han Xia Nisha S Thomas William L Berry Kenneth L Jones Vincent R Richard Rene P Zahedi Christoph H Borchers James D Johnson Elizabeth A Wellberg Source Type: research
Endothelial ER α promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle
Nat Commun. 2023 Aug 17;14(1):4989. doi: 10.1038/s41467-023-40562-w.ABSTRACTThe estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells, which have the potential to influence relative obesity, and processes in adipose tissue and skeletal muscle that impact glucose control. Here we show that independent of impact on events in adipose tissue, endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle. Endothelial ERα-deficient male mice are glucose intolerant...
Source: Cancer Control - August 17, 2023 Category: Cancer & Oncology Authors: Anastasia Sacharidou Ken Chambliss Jun Peng Jose Barrera Keiji Tanigaki Katherine Luby-Phelps İpek Özdemir Sohaib Khan Shashank R Sirsi Sung Hoon Kim Benita S Katzenellenbogen John A Katzenellenbogen Mohammed Kanchwala Adwait A Sathe Andrew Lemoff Chao Source Type: research
Protective effect of Salvia hispanica (chia seeds) against obesity induced ovarian disorders in rat model
Tissue Cell. 2023 Jul 5;83:102156. doi: 10.1016/j.tice.2023.102156. Online ahead of print.ABSTRACTThe main goal of the current report is to assess the protective impacts of chia seeds against obesity-induced ovarian dysfunctions with a trial to elucidate the mechanism of action. Forty rats were divided into 4 groups including lean untreated, lean consuming chia seeds, obese untreated, and rats consumed high-fat diet (HFD) mixed with ground chia seeds for 10 weeks. Anthropometric measures including visceral fat, peri-ovarian fat, ovarian weights, and duration of the estrous cycle were computed. Serum luteinizing (LH), folli...
Source: Tissue and Cell - July 12, 2023 Category: Cytology Authors: Eman Mahmoud FaragAllah Samah Attia Algharib Nehal I A Goda Nanees F El-Malkey Heba H Mahboub Shaimaa H El-Fayoumi Nawal Al-Hoshani Reham M Wahid Mohamed Aref Source Type: research
