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Insulin Resistance in Type 1 Diabetes Mellitus and Its Association with Patient ’s Micro- and Macrovascular Complications, Sex Hormones, and Other Clinical Data
ConclusionsAccording to stratified eGDR, IR was found for one-third of the current T1D population. Insulin resistant patients more frequently had microvascular complications and CVD events. Lower eGDR, longer diabetes duration, and lower HbA1c significantly increased CVD outcomes risk. IR was related to smoking, obesity, gender, age, and diabetes duration. Moreover, men ’s testosterone had a positive correlation with IR in T1D. Finally, patients with T1D and a positive family history of T2D were not susceptible to weight gain, while MS metabolic phenotype prevalence tended to be higher in obese than in lean patients with...
Source: Diabetes Therapy - December 1, 2019 Category: Endocrinology Source Type: research

Aging and the Male Reproductive System.
Authors: Kaufman JM, Lapauw B, Mahmoud A, T'Sjoen G, Huhtaniemi IT Abstract This narrative review presents an overview of present knowledge on fertility and reproductive hormones changes in aging men, the factors driving and modulating these changes, their clinical consequences, and benefits and risks of testosterone (T) therapy. Aging is accompanied by moderate decline of gamete quality and fertility. Population mean levels show mild total T decline, SHBG increase, steeper free T decline, and moderate LH increase with important contribution of comorbidities (e.g. obesity) to these changes. Sexual symptoms and lowe...
Source: Endocrine Reviews - March 20, 2019 Category: Endocrinology Tags: Endocr Rev Source Type: research

Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.
Abstract Circadian clock desynchronization has been implicated in the pathophysiology of cardiovascular disease and related risk factors (e.g., obesity, diabetes). Thus, we examined the extent to which circadian desynchronization exacerbates ischemic stroke outcomes and whether its detrimental effects on stroke severity and functional impairments are further modified by biological sex. Circadian entrainment of activity rhythms in all male and female rats was observed during exposure to a fixed light:dark (LD) 12:12 cycle but was severely disrupted when this LD cycle was routinely shifted (12hr advance/5d) for ≈ ...
Source: Endocrinology - June 1, 2016 Category: Endocrinology Authors: Earnest DJ, Neuendorff N, Coffman J, Selvamani A, Sohrabji F Tags: Endocrinology Source Type: research

Sex hormones and ischemic stroke: a prospective cohort study and meta-analyses.
CONCLUSIONS: Extreme low endogenous testosterone concentrations were associated with high risk of IS in men, a risk mediated in part by body mass index and hypertension. Whether or not low testosterone is a causal factor for IS or merely a biomarker of poor metabolic health is still not known. PMID: 26509870 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 28, 2015 Category: Endocrinology Authors: Holmegard HN, Nordestgaard BG, Jensen GB, Tybjærg-Hansen A, Benn M Tags: J Clin Endocrinol Metab Source Type: research