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Metformin-inclusive Therapy Reduces the Risk of Stroke in Patients with Diabetes: A 4-Year Follow-up Study
Metformin is a kind of oral hypoglycemic agents commonly prescribed to patients with diabetes mellitus. Although past studies had proven its protective effect on cardiovascular risk and related mortality, the evidence of metformin on stroke prevention was still insufficient and conflicting. Our study randomly selected 14,856 patients with diabetes from the database provided by the Taiwan National Health Research Institute, and 2 cohorts were formulated according to whether metformin was in the prescription record. All cases were followed up for 4 years to track their stroke incidence. As a result, 701 (17.5%) of 3999 diabe...
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2013 Category: Neurology Authors: Yuan-Yang Cheng, Hsin-Bang Leu, Tzeng-Ji Chen, Chen-Ling Chen, Chia-Hua Kuo, Shin-Da Lee, Chung-Lan Kao Tags: Original Articles Source Type: research

Implementation of a Structured Guideline-Based Program for the Secondary Prevention of Ischemic Stroke in China Clinical Sciences
Conclusions— The implementation of a program to improve adherence to secondary ischemic stroke prevention efforts in China is feasible, but these programs had only a limited impact on adherence and no impact on 1-year outcomes. Further development of a structured program to reduce vascular events after stroke is needed. Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00664846.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Peng, B., Ni, J., Anderson, C. S., Zhu, Y., Wang, Y., Pu, C., Wu, J., Wang, J., Zhou, L., Yao, M., He, J., Shan, G., Gao, S., Xu, W., Cui, L., on behalf of the SMART Investigators Tags: Secondary prevention Clinical Sciences Source Type: research

Sex Differences in Trends of Incidence and Mortality of First-Ever Stroke in Rural Tianjin, China, From 1992 to 2012 Clinical Sciences
Conclusions— There was a significant increase in the incidence of first-ever stroke in women annually and a declining trend in the male/female rate ratio in rural China during the past 21 years. These results suggest that stroke will become one of the major diseases affecting women in future decades in China.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Wang, J., Ning, X., Yang, L., Tu, J., Gu, H., Zhan, C., Zhang, W., Su, T.-C. Tags: Epidemiology Clinical Sciences Source Type: research

Elevated VLDL is associated with cardioembolic stroke and improved functional outcome in patients with acute ischemic stroke (P3.074)
CONCLUSIONS: The relationship between cardioembolic stroke and poor short-term outcomes likely underlies the association between vLDL and outcomes in our population. Further research is warranted to investigate the impact of vLDL in stroke etiology and patient outcomes.Disclosure: Dr. George has nothing to disclose. Dr. Monlezun, Jr has nothing to disclose. Dr. Samai has nothing to disclose. Dr. Waring has nothing to disclose. Dr. Dowell has nothing to disclose. Dr. Valmoria has nothing to disclose. Dr. Martin-Schild has received personal compensation for activities with Genentech as a speakers bureau participant.
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, A., Monlezun, Jr, D., Samai, A., Waring, E., Dowell, L., Valmoria, M., Martin-Schild, S. Tags: Cerebrovascular Disease and Interventional Neurology: Ischemic Stroke Outcome Source Type: research

Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men Epidemiology/Population
We report findings from a UK cohort study of 1375 European and 1074 South Asian men, not receiving antihypertensive medication, aged 40 to 69 years at baseline (1988–1991). Assessment included BP, blood tests, anthropometry, and questionnaires. Incident stroke was established at 20 years from death certification, hospital and primary care records, and participant report. South Asians had higher systolic BP, diastolic BP, and mean arterial pressure than Europeans, and similar pulse pressure. Associations between systolic BP or diastolic BP and stroke were stronger in South Asians than Europeans, after adjustment for a...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Eastwood, S. V., Tillin, T., Chaturvedi, N., Hughes, A. D. Tags: Cerebrovascular disease/stroke, Risk Factors, Epidemiology Epidemiology/Population Source Type: research

Improving Adherence to Secondary Stroke Prevention Strategies Through Motivational Interviewing: Randomized Controlled Trial Clinical Sciences
Conclusions— MI improved self-reported medication adherence. All other effects were nonsignificant, though in the direction of a treatment effect. Further study is required to determine whether MI leads to improvement in other important areas of functioning (eg, caregiver burden). Clinical Trial Registration— URL: http://www.anzctr.org.au. Unique identifier: ACTRN-12610000715077.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Barker-Collo, S., Krishnamurthi, R., Witt, E., Feigin, V., Jones, A., McPherson, K., Starkey, N., Parag, V., Jiang, Y., Barber, P. A., Rush, E., Bennett, D., Aroll, B. Tags: Behavioral/Psychosocial Treatment Clinical Sciences Source Type: research

Statin therapy in acute ischemic stroke: Time for large randomized trials?
Despite improvements in stroke mortality coupled with therapeutic advances, stroke patients often face the prospect of substantial disability. Novel strategies are clearly needed to further improve stroke outcomes. These might include new indications for previously licensed drugs proven effective and safe in related disease processes,1 such as statins. Unlike strong evidence supporting statin use in cardiovascular risk reduction and acute myocardial ischemia, their effects on cerebral tissue and potential benefits on stroke outcomes remain poorly understood and understudied. The only current stroke-specific indication for ...
Source: Neurology - March 21, 2016 Category: Neurology Authors: Charidimou, A., Merwick, A. Tags: All Cerebrovascular disease/Stroke, Infarction EDITORIALS Source Type: research

Impact of Increased Early Statin Administration on Ischemic Stroke Outcomes: A Multicenter Electronic Medical Record Intervention Stroke
Conclusions A simple EMR change increased early statin administration in ischemic stroke and was associated with improved clinical outcomes. This is, to our knowledge, the first EMR intervention study to show that a modification of an electronic order set resulted in improved clinical outcomes.
Source: JAHA:Journal of the American Heart Association - July 28, 2016 Category: Cardiology Authors: Flint, A. C., Conell, C., Klingman, J. G., Rao, V. A., Chan, S. L., Kamel, H., Cullen, S. P., Faigeles, B. S., Sidney, S., Johnston, S. C. Tags: Ischemic Stroke, Neuroprotectants Source Type: research

Yield of Dual Therapy With Statin and Ezetimibe in the Treat Stroke to Target Trial
CONCLUSIONS: In the TST trial (Treat Stroke to Target), targeting an LDL cholesterol of < 70 mg/dL with a combination of statin and ezetimibe compared with 100±10 mg/dL consistently reduced the risk of subsequent stroke.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT01252875. URL: clinicaltrialsregister.eu; Unique identifier: EUDRACT2009-A01280-57.PMID:36154103 | DOI:10.1161/STROKEAHA.122.039728
Source: Atherosclerosis - September 26, 2022 Category: Cardiology Authors: Pierre Amarenco Jong S Kim Julien Labreuche Hugo Charles Maurice Giroud Byung-Chul Lee Philippa C Lavall ée Marie-H élène Mahagne Elena Meseguer Norbert Nighoghossian Philippe Gabriel Steg Éric Vicaut Eric Bruckert Treat Stroke to Target Investigators Source Type: research

Demographic, Clinical, and Radiologic Predictors of Neurologic Deterioration in Patients with Acute Ischemic Stroke
One-third of patients with acute ischemic stroke develop early neurologic worsening, which is associated with increased mortality and long-term functional disability. We investigated the predictive factors for neurologic deterioration in patients with acute ischemic stroke within 1 week of onset. We retrospectively investigated 643 patients who were admitted within 2 days of acute ischemic stroke between April 2007 and March 2010. Neurologic deterioration was defined as an increase of 4 points or more in the National Institutes of Health Stroke Scale (NIHSS) score within 1 week of admission. We retrieved data on demograph...
Source: Journal of Stroke and Cerebrovascular Diseases - September 9, 2011 Category: Neurology Authors: Nobukazu Miyamoto, Yasutaka Tanaka, Yuji Ueno, Miyako Kawamura, Yoshiaki Shimada, Ryota Tanaka, Nobutaka Hattori, Takao Urabe Tags: Original Articles Source Type: research

Cholesterol Levels and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— Total cholesterol level is inversely associated with risk of hemorrhagic stroke. Higher level of low-density lipoprotein cholesterol seems to be associated with lower risk of hemorrhagic stroke. High-density lipoprotein cholesterol level seems to be positively associated with risk of intracerebral hemorrhage.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Wang, X., Dong, Y., Qi, X., Huang, C., Hou, L. Tags: Risk Factors, Acute Cerebral Hemorrhage, Lipid and lipoprotein metabolism Clinical Sciences Source Type: research

Differences in lipid profiles in two Hispanic ischemic stroke populations
ConclusionWe found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low‐density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race‐ethnic group and may lead to different secondary prevention strategies.
Source: International Journal of Stroke - December 20, 2013 Category: Neurology Authors: A. Arauz, J. G. Romano, A. Ruiz‐Franco, T. Shang, C. Dong, T. Rundek, S. Koch, B. Hernández‐Curiel, J. Pacheco, P. Rojas, F. Ruiz‐Navarro, M. Katsnelson, R. L. Sacco Tags: Research Source Type: research

Adiponectin and Risk of Stroke: Prospective Study and Meta-analysis Clinical Sciences
Conclusions— Adiponectin is not associated with risk of stroke. If anything, adiponectin relates directly to stroke risk after controlling for risk factors that favorably correlate with adiponectin.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Arregui, M., Buijsse, B., Fritsche, A., di Giuseppe, R., Schulze, M. B., Westphal, S., Isermann, B., Boeing, H., Weikert, C. Tags: Risk Factors, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

The Effect Of Statin Pretreatment And Serum Lipid Values On Hemorragic Conversion After rt-PA for Acute Ischemic Stroke (P4.225)
CONCLUSIONS:Our study showed no significant correlation between PSS or lipid profile with ICH following IVT. Furthermore, no association with DmRS was found. Additional larger studies on PSS may be beneficial to determine the effects of statins on ICH risk.Disclosure: Dr. Khawaja has nothing to disclose. Dr. Lyerly has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Sands has nothing to disclose. Dr. Bavarsad Shahripour has nothing to disclose. Dr. Alexandrov has received personal compensation for activities with Genentech, Inc.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khawaja, A., Lyerly, M., Kumar, G., Sands, K., Bavarsad Shahripour, R., Alexandrov, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Atherogenic Dyslipidemia and Residual Cardiovascular Risk in Statin-Treated Patients Clinical Sciences
Conclusions— The presence of atherogenic dyslipidemia was associated with higher residual cardiovascular risk in PERFORM and SPARCL subjects with stroke or transient ischemic attack receiving statin therapy. Specific therapeutic interventions should now be trialed to address this residual risk.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Sirimarco, G., Labreuche, J., Bruckert, E., Goldstein, L. B., Fox, K. M., Rothwell, P. M., Amarenco, P., on behalf of the PERFORM and SPARCL Investigators and Committees, Bousser, Chamorro, Ford, Fox, Fisher, Hennerici, Mattle, Rothwell, Callahan, Goldste Tags: Acute Cerebral Infarction, Primary and Secondary Stroke Prevention, Other Stroke Treatment - Medical, Transient Ischemic Attacks Clinical Sciences Source Type: research