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Association and mediating mechanism between remnant cholesterol and first-ever stroke among the Chinese general population
CONCLUSION: High RC increased the risk of first-ever stroke in the Chinese general population without previous stroke and myocardial infarction, partially through the pathway of hypertension. RC might be a potential target for the primary prevention of stroke.PMID:37304024 | PMC:PMC10247974 | DOI:10.3389/fnins.2023.1161367
Source: Atherosclerosis - June 12, 2023 Category: Cardiology Authors: Heng Li Shuai Miao Lu Chen Bin Liu Yan-Bin Li Rui-Sheng Duan Source Type: research

Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets
Chin J Integr Med. 2023 Mar 13. doi: 10.1007/s11655-023-3545-z. Online ahead of print.ABSTRACTThe prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia can lead to a range of diseases such as atherosclerosis, stroke, coronary heart disease, myocardial infarction, diabetes, and kidney failure, etc. High circulating low-density lipoprotein cholesterol (LDL-C) is one of the causes of hyperlipidemia. LDL-C in the blood binds to LDL receptor (LDLR) and regulates cholesterol...
Source: Atherosclerosis - March 13, 2023 Category: Cardiology Authors: Su-Su Liu Tong Yu Yan-Fang Qiao Shu-Xiao Gu Xin-Lou Chai Source Type: research

The Projected Impact of Population-Wide Achievement of LDL Cholesterol & lt;70 mg/dL on the Number of Recurrent Events Among US Adults with ASCVD
ConclusionA substantial number of recurrent ASCVD events could be averted over 10 years if all US adults with ASCVD achieved, and maintained, an LDL-C<70 mg/dL.
Source: Cardiovascular Drugs and Therapy - October 2, 2021 Category: Cardiology Source Type: research

The Debate Over Egg Consumption and Incident Cardiovascular Disease
There is a great debate regarding the association of cholesterol intake from egg consumption and the incidence of cardiovascular disease (CVD). Most studies show that moderate egg consumption is not associated with a significant increase in CVD, stroke, heart failure, and type 2 diabetes mellitus (T2DM), whereas others dispute this fact and state that there is an association with increased egg consumption, especially if they are consumed with saturated fats. In addition, the recent relaxation of cholesterol intake to greater than 300 mg/d by the American College of Cardiology/American Heart Association Nutritional Guidelin...
Source: Cardiology in Review - August 14, 2021 Category: Cardiology Tags: Review Articles Source Type: research

Height Is Associated with Dyslipidemia in Korean Premenopausal Women: Data from the Korea National Health and Nutrition Examination Survey
Conclusion: There was a dose-dependent correlation between adult height and adverse lipid profile in premenopausal Korean women who did not have CVD. This finding could serve as further evidence that dyslipidemia can be a link between shortness and CVD.Cardiology
Source: Cardiology - September 10, 2020 Category: Cardiology Source Type: research

Impact of nutritional index on long-term outcomes of elderly patients with coronary artery disease: sub-analysis of the SHINANO 5  year registry
In this study, patients were categorized into TCBI quartile groups. The primary endpoints were the occurre nce of major adverse cardiac and cerebrovascular events (MACCE), including all-cause death, stroke, and myocardial infarction at 5 year. The mean duration of follow up was 4.3 ± 1.7 years. The average patient age was 80.9 ± 4.3 years. MACCE was observed in 61 (40.9%) patients in the low est TCBI quartile group. Kaplan–Meier analysis demonstrated an inverse relationship between MACCE and TCBI (log-lankP <  0.001). Multivariate analysis demonstrated that low TCBI significantly predicted the inciden...
Source: Heart and Vessels - June 29, 2020 Category: Cardiology Source Type: research

Trends in nutritional intake and coronary risk factors over 60  years among Japanese men in Tanushimaru
AbstractWe investigated the relationship between time trends in nutrient intake and coronary risk factors/mortality rates in Tanushimaru, a Japanese cohort of the Seven Countries Study. All men between the ages of 40 and 64 were enrolled. Subjects numbered 628 in 1958, 539 in 1977, 602 in 1982, 752 in 1989, 402 in 1999, 329 in 2009, and 160 in 2018. Eating patterns were evaluated by 24-h dietary recall from 1958 through 1989, and by a food frequency questionnaire administered from 1999 through 2018. The total daily energy intake decreased from 2,837  kcal in 1958 to 2,096 kcal in 2018. Carbohydrate intake as a percentage...
Source: Heart and Vessels - January 28, 2020 Category: Cardiology Source Type: research

Dietary Cholesterol and Cardiovascular Risk: A Science Advisory From the American Heart Association.
sis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Peripheral Vascular Disease; and Stroke Council Abstract The elimination of specific dietary cholesterol target recommendations in recent guidelines has raised questions about its role with respect to cardiovascular disease. This advisory was developed after a review of human studies on the relationship of dietary cholesterol with blood lipids, lipoproteins, and cardiovascular disease risk to address questions about the relevance of dietary cholesterol guidance for heart health. Evidence from observat...
Source: Circulation - December 15, 2019 Category: Cardiology Authors: Carson JAS, Lichtenstein AH, Anderson CAM, Appel LJ, Kris-Etherton PM, Meyer KA, Petersen K, Polonsky T, Van Horn L, American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Arteriosclerosis, Thromb Tags: Circulation Source Type: research