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Condition: Cholesterol
Drug: Metformin
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Total 498 results found since Jan 2013.
AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway
In this study, we found that activation of AMPK by AICAR and metformin inhibits foam cell formation via suppression of mTOR in macrophages. Specifically, activation of AMPK indirectly reduced the phosphorylation level of mTOR at Ser2448 and promoted the expression of cholesterol efflux transporters and cholesterol efflux. These inhibitory effects on foam cell formation were counteracted by mTOR activators. Metformin, a more nonspecific AMPK activator than AICAR, appears to inhibit foam cell formation via anti-inflammatory effects in addition to suppression of the mTOR pathway. The results of this study suggest that the dev...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Reina Owaki Hiromasa Aoki Kohki Toriuchi Yasumichi Inoue Hidetoshi Hayashi Satoru Takeshita Hiroki Kakita Yasumasa Yamada Mineyoshi Aoyama Source Type: research
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metformin, cognitive function, and changes in the gut microbiome
Endocr Rev. 2023 Aug 21:bnad029. doi: 10.1210/endrev/bnad029. Online ahead of print.ABSTRACTThe decline in cognitive function and the prevalence of neurodegenerative disorders are among the most serious threats to health in old age. The prevalence of dementia has reached 50 million people worldwide and has become one of the major public health problems. The causes of age-related cognitive impairment are multiple, complex, and difficult to determine. However, type 2 diabetes (T2D) is linked to an enhanced risk of cognitive impairment and dementia. Human studies have shown that patients with T2D exhibit dysbiosis of the gut ...
Source: ENDOCR REV - August 21, 2023 Category: Endocrinology Authors: Marisel Rosell-D íaz Jos é Manuel Fernández-Real Source Type: research
Salvia Officinalis Improves Glucose Uptake and Suppresses Ectopic Lipid Deposition in Obese Rats with Metabolic Syndrome
CONCLUSION: The findings imply that SAGEAE could be used as a new pharmaceutical formula in the treatment of obesity.PMID:37581324 | DOI:10.2174/1389201024666230811104740
Source: Current Pharmaceutical Biotechnology - August 15, 2023 Category: Biotechnology Authors: Diana A ALsherif Mohammed A Hussein Suzan S Abuelkasem Soha A Hassan Michael Wink Source Type: research
HDL abnormalities in type 2 diabetes: Clinical implications
Atherosclerosis. 2023 Aug 3:117213. doi: 10.1016/j.atherosclerosis.2023.117213. Online ahead of print.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) represents the primary cause of mortality among patients with Type 2 Diabetes Mellitus (T2DM). In this population, High-Density Lipoprotein (HDL) particles exhibit abnormalities in number, composition, and function, culminating in diminished anti-atherosclerotic capabilities despite normal HDL cholesterol (HDL-C) concentrations. Hyperglycemic conditions contribute to these alterations in HDL kinetics, composition, and function, causing T2DM patients' HDL particles to e...
Source: Atherosclerosis - August 14, 2023 Category: Cardiology Authors: Alexandro J Martagon Rafael Zubir án Rogelio Gonz ález-Arellanes Samantha Praget-Bracamontes J Adri án Rivera-Alcántara Carlos A Aguilar-Salinas Source Type: research
Novel pharmacological approaches in abdominal aortic aneurysm
Clin Sci (Lond). 2023 Aug 14;137(15):1167-1194. doi: 10.1042/CS20220795.ABSTRACTAbdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health issue with an unmet medical need for therapy. This disease is featured by a progressive dilation of the abdominal aorta, boosted by atherosclerosis, ageing, and smoking as major risk factors. Aneurysm growth increases the risk of aortic rupture, a life-threatening emergency with high mortality rates. Despite the increasing progress in our knowledge about the etiopathology of AAA, an effective pharmacological treatment against this disorder remains elusive and...
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: L ídia Puertas-Umbert Rafael Almendra-Pegueros Francesc Jim énez-Altayó Marc Sirvent Mar ía Galán Jos é Martínez-González Cristina Rodr íguez Source Type: research
Advanced effect of curcumin and resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K/AKT/mTOR and HIF-1/VEGF cascade
This study aims to investigate the effect of curcumin (Cur) and resveratrol (Res) as a potential combination therapy on MAFLD. Cur, Res and Cur+Res were tested in palmitic acid (PA)-induced-HepG2 cells. MAFLD model was established using Goto-Kakizaki rats. The animals were treated with vehicle control (model group), Cur (150 mg/kg), Res (150 mg/kg), Cur+Res (150 mg/kg, 8:2, w/w), or metformin (Met, positive control, 400 mg/kg/day) via oral gavage for 4 weeks. Wistar rats were used as the control group. Network pharmacology was conducted to elucidate the molecular actions of Cur and Res, followed by q-PCR and immunoblotting...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 6, 2023 Category: Drugs & Pharmacology Authors: Yuhui He Huan Wang Shiling Lin Tao Chen Dennis Chang Yibin Sun Chenxiang Wang Yang Liu Yusheng Lu Jianyuan Song Shaohua Li Wen Xu Yanxiang Lin Yanfang Zheng Xian Zhou Qiumei Huang Mingqing Huang Source Type: research
