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Condition: Hypothermia
Procedure: Perfusion

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Total 64 results found since Jan 2013.

Induction of Cooling With a Passive Head and Neck Cooling Device: Effects on Brain Temperature After Stroke Clinical Sciences
Conclusions— Although the decrease of brain temperature after Sovika cooling device application was statistically significant, we doubt clinical relevance of this rather limited effect (–0.36°C). Moreover, the transient increases of blood pressure and ICP warrant caution.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Poli, S., Purrucker, J., Priglinger, M., Diedler, J., Sykora, M., Popp, E., Steiner, T., Veltkamp, R., Bosel, J., Rupp, A., Hacke, W., Hametner, C. Tags: Cerebrovascular disease/stroke, CPR and emergency cardiac care, Other Treatment, Emergency treatment of Stroke Clinical Sciences Source Type: research

Mild focal hypothermia regulates the dynamic polarization of microglia after ischemic stroke in mice.
Conclusions Hypothermia is protective following ischemic stroke and can reduce brain tissue loss. Moreover, hypothermia shifts the polarization of microglia from the M1 to the M2 phenotype in the ischemic mice brain. This observed biological phenomenon may partially explain the protective effects seen due to hypothermia in acute ischemic stroke. PMID: 29619889 [PubMed - as supplied by publisher]
Source: Neurological Research - April 7, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Catheter based selective hypothermia reduces stroke volume during focal cerebral ischemia in swine
Conclusions Selective moderate hypothermia was rapidly induced using endovascular techniques in a clinically realistic swine stroke model. A significant reduction in stroke volume on MRI was observed. Endovascular selective hypothermia can provide neuroprotection within time frames relevant to acute ischemic stroke treatment.
Source: Journal of NeuroInterventional Surgery - March 15, 2016 Category: Neurosurgery Authors: Mattingly, T. K., Denning, L. M., Siroen, K. L., Lehrbass, B., Lopez-Ojeda, P., Stitt, L., Pelz, D. M., Das, S., Ang, L.-C., Lee, D. H., Lownie, S. P. Tags: Editor''s choice, Basic science Source Type: research

A Mathematical Model of Cellular Metabolism During Ischemic Stroke and Hypothermia
Stroke is a major cause of death and disability worldwide. Therapeutic hypothermia is a potentially useful neuroprotective treatment. A mathematical model of brain metabolism during stroke is extended here to simulate the effect of hypothermia on cell survival. Temperature decreases were set to reduce chemical reaction rates and slow diffusion through ion channels according to the $Q_{10}$ rule. Heat delivery to tissues was set to depend on metabolic heat generation rate and perfusion. Two cooling methods, scalp and vascular, were simulated to approximate temperature variation in the brain during treatment. Cell death was ...
Source: IEEE Transactions on Biomedical Engineering - January 17, 2014 Category: Biomedical Engineering Source Type: research

Pharmacologically-induced hypothermia by TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 minutes after reperfusion.
We examined effectiveness and specificity of pharmacological hypothermia by transient receptor potential vanilloid 1 (TRPV1) channel agonism in the treatment of focal cerebral I/R. Core temperature (Tcore) was measured after subcutaneous infusion of TRPV1 agonist, dihydrocapsaicin (DHC), in conscious C57BL/6 WT and TRPV1 KO mice. Acute measurements of heart rate (HR), mean arterial pressure (MAP), and cerebral perfusion were measured before and after DHC treatment. Focal cerebral I/R (one hour ischemia + 24 hours reperfusion) was induced by distal middle cerebral artery occlusion. Hypothermia (> 8 hours) was initiated 9...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - December 4, 2013 Category: Physiology Authors: Cao Z, Balasubramanian A, Marrelli SP Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Combined local hypothermia and recanalization therapy for acute ischemic stroke: Estimation of brain and systemic temperature using an energetic numerical model
Publication date: Available online 4 July 2019Source: Journal of Thermal BiologyAuthor(s): Yannick Lutz, Axel Loewe, Stephan Meckel, Olaf Dössel, Giorgio CattaneoAbstractLocal brain hypothermia is an attractive method for providing cerebral neuroprotection for ischemic stroke patients and at the same time reducing systemic side effects of cooling. In acute ischemic stroke patients with large vessel occlusion, combination with endovascular mechanical recanalization treatment could potentially allow for an alleviation of inflammatory and apoptotic pathways in the critical phase of reperfusion. The direct cooling of arterial...
Source: Journal of Thermal Biology - July 6, 2019 Category: Biology Source Type: research

Commentary: Stroke after type A aortic dissection repair —A web of risk with no single answer
In this issue of the Journal, Ghoreishi and colleagues1 have performed a tour de force in attempting to analyze 5 major factors potentially associated with stroke after type A aortic dissection repair. The etiology of stroke after aortic surgery is an entanglement of numerous complex factors that place patients at risk for both ischemic and embolic neurologic insults. Decisions about the extent of surgical repair, cannulation site, cerebral perfusion strategy, and degree of hypothermia are all interrelated.
Source: The Journal of Thoracic and Cardiovascular Surgery - June 19, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Robert B. Hawkins, J. Hunter Mehaffey, John A. Kern Tags: Commentary Source Type: research

The intra-arterial selective cooling infusion system: A  mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy
CONCLUSION: This prototype instrument system could safely cool simulated blood in vitro and reperfuse it to the target cerebral blood vessel. This technique could promote the clinical application of an autologous blood perfusion system for stroke therapy.PMID:35702957 | DOI:10.1111/cns.13883
Source: CNS Neuroscience and Therapeutics - June 15, 2022 Category: Neuroscience Authors: Miaowen Jiang Ming Li Yuan Gao Longfei Wu Wenbo Zhao Chuanhui Li Chengbei Hou Zhengfei Qi Kun Wang Shiqiang Zheng Zhichen Yin Chuanjie Wu Xunming Ji Source Type: research

Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion
We examined effectiveness and specificity of pharmacological hypothermia (PH) by transient receptor potential vanilloid 1 (TRPV1) channel agonism in the treatment of focal cerebral I/R. Core temperature (Tcore) was measured after subcutaneous infusion of TRPV1 agonist dihydrocapsaicin (DHC) in conscious C57BL/6 WT and TRPV1 knockout (KO) mice. Acute measurements of heart rate (HR), mean arterial pressure (MAP), and cerebral perfusion were measured before and after DHC treatment. Focal cerebral I/R (1 h ischemia + 24 h reperfusion) was induced by distal middle cerebral artery occlusion. Hypothermia (>8 h) was initiated 9...
Source: AJP: Regulatory, Integrative and Comparative Physiology - January 15, 2014 Category: Physiology Authors: Cao, Z., Balasubramanian, A., Marrelli, S. P. Tags: Neural Control Source Type: research

Selective Brain Hypothermia for Ischemic MCA-M1 Stroke: Influence of Cerebral Arterial Circulation in a 3D Brain Temperature Model
Acute ischemic stroke is a major health problem with a high mortality rate and a high risk for permanent disabilities. Selective brain hypothermia has the neuroprotective potential to possibly lower cerebral harm. A recently developed catheter system enables to combine endovascular blood cooling and thrombectomy using the same endovascular access. By using the penumbral perfusion via leptomeningeal collaterals, the catheter aims at enabling a cold reperfusion, which mitigates the risk of a reperfusion injury. However, cerebral circulation is highly patient-specific and can vary greatly. Since direct measurement of remainin...
Source: IEEE Transactions on Biomedical Engineering - January 22, 2021 Category: Biomedical Engineering Source Type: research

The impact of unilateral versus bilateral antegrade cerebral perfusion on surgical outcomes after aortic arch replacement: A propensity-matched analysis
Conclusions: Using unilateral antegrade cerebral perfusion in a pressure-controlled manner during mild systemic hypothermia is a safe protection strategy in elective aortic arch surgery, associated with similar morbidity and mortality in comparison with bilateral antegrade cerebral perfusion, even if total arch replacement is required. Bilateral antegrade cerebral perfusion reveals a trend of higher incidence of stroke, probably due to manipulation on the arch vessels.
Source: The Journal of Thoracic and Cardiovascular Surgery - January 6, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Andreas Zierer, Petar Risteski, Ali El-Sayed Ahmad, Anton Moritz, Anno Diegeler, Paul P. Urbanski Tags: Acquired Cardiovascular Disease Source Type: research

Unilateral Versus Bilateral Cerebral Perfusion for Acute Type A Aortic Dissection
Conclusions As one of the largest single-center studies of the efficacy of u-ACP and b-ACP in patients with type A aortic dissection, operative mortality, stroke, temporary neurologic dysfunction, and renal failure rates were similar in both. In this intrinsically complex disease, survival is the most important outcome; u-ACP may provide cardiac surgeons with valuable technical simplicity during challenging procedures, and b-ACP may be justified for circulatory arrest times of more than 30 minutes.
Source: The Annals of Thoracic Surgery - December 30, 2014 Category: Cardiovascular & Thoracic Surgery Source Type: research

Deep Hypothermia + Retrograde Cerebral Perfusion vs. Moderate Hypothermia + Antegrade Cerebral Perfusion for Arch Surgery
ConclusionsAlthough there was no significant difference in clinically evident neurologic injury, this pilot study suggests that MHCA+ACP may be associated with a higher incidence of radiographic neurologic injury than DHCA+RCP in patients undergoing elective hemiarch replacement.
Source: The Annals of Thoracic Surgery - November 16, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Deep Hypothermia + Retrograde Cerebral Perfusion vs. Moderate Hypothermia + Antegrade Cerebral Perfusion for Arch Surgery.
CONCLUSIONS: Although there was no significant difference in clinically evident neurologic injury, this pilot study suggests that MHCA+ACP may be associated with a higher incidence of radiographic neurologic injury than DHCA+RCP in patients undergoing elective hemiarch replacement. PMID: 30448484 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - November 15, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Leshnower BG, Rangaraju S, Allen JW, Stringer AY, Gleason TG, Chen EP Tags: Ann Thorac Surg Source Type: research