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Condition: Pre-eclampsia

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Total 27 results found since Jan 2013.

HMOX1 Participates in Pre-Eclampsia by Regulating the Proliferation, Apoptosis, and Angiogenesis Modulation Potential of Mesenchymal Stem Cells via VEGF
Biochem Genet. 2023 Aug 12. doi: 10.1007/s10528-023-10474-x. Online ahead of print.ABSTRACTMesenchymal stem cells (MSCs) are involved in the pathogenesis of pre-eclampsia (PE). Heme oxygenase (HMOX) protects against placental cytotoxic injuries associated with PE. Here, we aimed to clarify the roles of HMOX1 in MSC proliferation and apoptosis, trophoblast cell migration, and regulation of angiogenesis, and assess its involvement in the pathogenesis of PE. HMOX1 and vascular endothelial growth factor (VEGF) expression levels in decidual tissues and decidua-derived MSCs (dMSCs) of healthy pregnant women and patients with PE ...
Source: Biochemical Genetics - August 12, 2023 Category: Genetics & Stem Cells Authors: Juan Shi Min Su Source Type: research

EID1 plays a protective role in early-onset pre-eclampsia via promoting proliferation and invasion in trophoblast cells
CONCLUSIONS: EID1 promoted proliferation and invasion of cultured trophoblast cells with possible involvement of Akt/β-catenin signaling. These findings may provide novel insights for the diagnosis and treatment of early-onset pre-eclampsia in a clinic.PMID:35038162 | DOI:10.5603/FHC.a2022.0001
Source: Folia Histochemica et Cytobiologica - January 17, 2022 Category: Cytology Authors: Ying Li Jiuxiang Feng Yue Bian Wei Cheng Chong Qiao Source Type: research

Excess fibronectin 1 participates in pathogenesis of pre-eclampsia by promoting apoptosis and autophagy in vascular endothelial cells
AbstractPlasma fibronectin 1 (FN1) levels are elevated in individuals with pre-eclampsia (PE), which may be applied as a possible b marker for vascular endothelial injury during PE. In the present study, the possible role of FN1 in the pathogenesis of PE and regulation of apoptosis and autophagy in vascular endothelial cells was explored. Plasma FN1 levels in 80 patients with PE and 40 healthy pregnant individuals were measured using ELISA to verify its relationship with the severity of PE. pcDNA3.1-FN1 or FN1-small interfering (si) RNA was used to manipulate the expression of FN1 in human umbilical vein endothelial cells ...
Source: Molecular Human Reproduction - April 20, 2021 Category: Molecular Biology Source Type: research

Myeloid Derived Suppressor Cells Interactions With Natural Killer Cells and Pro-angiogenic Activities: Roles in Tumor Progression
Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia
Conclusion: AT1-AA induced podocyte damage in a dose-dependent manner. The underlying mechanism might involve activation of the TRPC6 –calcium/calcineurin pathway. This study provides new details regarding podocyte injury and the mechanism underlying the generation of proteinuria in pre-eclampsia.Kidney Blood Press Res 2018;43:1666 –1676
Source: Kidney and Blood Pressure Research - October 31, 2018 Category: Urology & Nephrology Source Type: research

Decidual ACVR2A regulates extravillous trophoblast functions of adhesion, proliferation, migration and invasion in vitro
Publication date: April 2018Source: Pregnancy Hypertension, Volume 12Author(s): Hannah E.J. Yong, Padma Murthi, Bill Kalionis, Rosemary J. Keogh, Shaun P. BrenneckeAbstractDecidual stromal cells form the largest proportion of maternal cells at the maternal-fetal interface. Our aim was to investigate the role of the pre-eclampsia associated decidual activin receptor, ACVR2A, in regulating trophoblast functions at this interface. St-T1b and HTR-8/SVneo cell lines were used to model decidual stromal and trophoblast cells respectively. St-T1b conditioned medium inhibited HTR-8/SVneo adhesion, proliferation, migration and invas...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - July 10, 2018 Category: OBGYN Source Type: research