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Specialty: Cardiology
Condition: Heart Failure
Procedure: Transplants
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Total 143 results found since Jan 2013.
Atherosclerosis on CT coronary angiography and risk of long-term cardiovascular events post liver transplantation
CONCLUSION: The standardized CAD-RADS classification on CTCA predicted the occurrence of cardiovascular outcomes following LT, with a potential to increase utilization of preventive cardiovascular therapies.PMID:37432891 | DOI:10.1097/LVT.0000000000000215
Source: Atherosclerosis - July 11, 2023 Category: Cardiology Authors: Thalys Sampaio Rodrigues Anoop N Koshy Paul J Gow Laurence Weinberg Benjamin Cailes Adam Testro Gerard Smith Han S Lim Andrew W Teh Ruth P Lim Omar Farouque Source Type: research
Improved mortality and haemodynamics with milrinone in cardiogenic shock due to acute decompensated heart failure
ConclusionsThe use of milrinone compared with dobutamine in patients with ADHF-CS is associated with lower 30 day mortality and improved haemodynamics. These findings warrant further study in future randomized controlled trials.
Source: ESC Heart Failure - June 16, 2023 Category: Cardiology Authors: Eduard Rodenas ‐Alesina,
Fernando Luis Scolari,
Vicki N. Wang,
Darshan H. Brahmbhatt,
Vesna Mihajlovic,
Nicole L. Fung,
Madison Otsuki,
Filio Billia,
Christopher B. Overgaard,
Adriana Luk Tags: Original Article Source Type: research
Adrenomedullin peptides and precursor levels in relation to haemodynamics and prognosis after heart transplantation
ConclusionsElevated plasma levels of ADM may be a marker of pressure/volume overload in HF patients with PH, as well as long-term prognosis after HT. In line with previous studies, our findings additionally confirm that ADM may be a marker of venous congestion in HF. Further studies are encouraged to establish a deeper understanding of the properties of ADM and its relationship with HF and PH, in order to potentially facilitate clinical management of HF and associated PH.
Source: ESC Heart Failure - May 29, 2023 Category: Cardiology Authors: Abdulla Ahmed,
Kriss Kania,
Hebba Abdul Rahim,
Salaheldin Ahmed,
G öran Rådegran Tags: Original Article Source Type: research
Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: From mechanisms to therapy
Biomed Pharmacother. 2023 May 2;163:114817. doi: 10.1016/j.biopha.2023.114817. Online ahead of print.ABSTRACTCardiovascular and cerebrovascular diseases (CVDs) remain an intractable problem and have high morbidity and mortality worldwide, as well as substantial health and economic burdens, representing an urgent clinical need. In recent years, the focus of research has shifted from the use of mesenchymal stem cells (MSCs) for transplantation to the use of their secretory exosomes (MSC-exosomes) for the treatment of numerous CVDs, including atherosclerosis, myocardial infarction (MI), heart failure (HF), ischemia/reperfusio...
Source: Atherosclerosis - May 4, 2023 Category: Cardiology Authors: Yanhong Pan Weipeng Wu Xiaoxin Jiang Yunhong Liu Source Type: research
Cardiac transplant and exercise cardiac rehabilitation
AbstractCardiac transplantation is the final therapeutic option for patients with end-stage heart failure. Most patients experience a favorable functional ability post-transplant. However, episodes of acute rejection, and multiple comorbidities such as hypertension, diabetes mellitus, chronic kidney disease and cardiac allograft vasculopathy are common. The number of transplants has increased steadily over the past two decades with 3,817 operations performed in the United States in 2021. Patients have abnormal exercise physiologic responses related to surgical cardiac denervation, diastolic dysfunction, and the legacy of r...
Source: Heart Failure Reviews - April 4, 2023 Category: Cardiology Source Type: research
Angiotensin-converting Enzyme Inhibitors (ACE) And Angiotensin Receptor Blockers (ARB) Appear To Attenuate Stroke Risk Over Time In Patients With Left Ventricular Assist Devices
Left ventricular assist devices (LVADs) are used as a bridge to transplant or as a destination therapy for patients with end-stage heart failure. LVADs are associated with increased stroke risk, and many patients on LVAD are treated with ACE/ARBs and vasodilators to keep their mean arterial pressure (MAP) at goal to minimize the risk of stroke. We hypothesized that ACE/ARBs and vasodilators can reduce the 5-year risk of stroke in patients with LVAD.
Source: Journal of Cardiac Failure - April 1, 2023 Category: Cardiology Authors: Jae-Hoon Chung, Jonathan Wright, Mark Boulous, Djhenne Dalmacy, Sakima Smith Tags: 132 Source Type: research
Clonal Hematopoiesis and the Heart: a Toxic Relationship
Curr Oncol Rep. 2023 Mar 15. doi: 10.1007/s11912-023-01398-1. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Clonal hematopoiesis (CH) refers to the expansion of hematopoietic stem cell clones and their cellular progeny due to somatic mutations, mosaic chromosomal alterations (mCAs), or copy number variants which naturally accumulate with age. CH has been linked to increased risk of blood cancers, but CH has also been linked to adverse cardiovascular outcomes.RECENT FINDINGS: A combination of clinical outcome studies and mouse models have offered strong evidence that CH mutations either correlate with or cause atheroscle...
Source: Atherosclerosis - March 15, 2023 Category: Cardiology Authors: Jeffrey L Jensen Saumya Easaw Travis Anderson Yash Varma Jiandong Zhang Brian C Jensen Catherine C Coombs Source Type: research
Identifying patients at risk: multi ‐centre comparison of HeartMate 3 and HeartWare left ventricular assist devices
ConclusionsHM3 patients have a significantly better survival and a lower incidence of ischaemic strokes and pump thrombosis than HVAD patients. This survival difference persisted after 2 years of implantation. Additional research using post-operative variables is warranted to identify which HVAD patients need an upgrade to HM3 or expedited transplantation.
Source: ESC Heart Failure - February 17, 2023 Category: Cardiology Authors: Lieke Numan,
Daniel Zimpfer,
Osnat Itzhaki Ben Zadok,
Emmeke Aarts,
Michiel Morshuis,
Sabina P.W. Guenther,
Julia Riebandt,
Dominik Wiedemann,
Faiz Z. Ramjankhan,
Anne ‐Marie Oppelaar,
Tuvia Ben‐Gal,
Binyamin Ben‐Avraham,
Folkert W. Asse Tags: Original Article Source Type: research
Characteristics and long ‐term survival of patients with left ventricular non‐compaction cardiomyopathy
ConclusionsOur study questions the criteria being used for the diagnosis of LVNC. Further evaluation of CMR variables and association of these findings with demographic variables and survival is mandatory.
Source: ESC Heart Failure - September 16, 2022 Category: Cardiology Authors: Emre Demir,
Selen Bayraktaro ğlu,
Akın Çinkooğlu,
Aytaç Candemir,
Yeşim B. Candemir,
Rıza O. Öztürk,
Ömer F. Dadaş,
Mehmet N. Orman,
Mehdi Zoghi,
Azem Akıllı,
Naim Ceylan,
Cemil Gürgün,
Sanem Nalbantgil Tags: Original Article Source Type: research
Elevated plasma WIF ‐1 levels are associated with worse prognosis in heart failure with pulmonary hypertension
ConclusionsThe present study demonstrated that LHF-PH patients have higher plasma WIF-1 levels than healthy controls, suggesting that plasma WIF-1 may be a potential future prognostic biomarker in LHF-PH. Its prognostic capability could be further refined by including it in a multi-marker panel. Further studies are needed to establish the potential role of WIF-1 in LHF-PH pathophysiology in larger cohorts to determine its clinical applicability.
Source: ESC Heart Failure - September 9, 2022 Category: Cardiology Authors: Kriss Kania,
Abdulla Ahmed,
Salaheldin Ahmed,
G öran Rådegran Tags: Original Article Source Type: research
Oral milrinone for management of refractory right ventricular failure in patients with left ventricular assist devices
ConclusionsOral milrinone appears safe for long-term use in the outpatient setting when combined with therapeutic monitoring in this complex medical cohort with limited management options. Further study is needed to ascertain whether this treatment is effective in reducing heart failure symptoms and admissions.
Source: ESC Heart Failure - July 30, 2022 Category: Cardiology Authors: Waqas Akhtar,
Charles Butcher,
Andrew Morley ‐Smith,
Fernando Riesgo Gil,
Owais Dar,
Veronica Baston,
John Dunning,
Haifa Lyster Tags: Short Communication Source Type: research
Preventive Effect of Bone Marrow Mononuclear Cell Transplantation on Acute Myocardial Infarction-Induced Heart Failure: A Meta-analysis of Randomized Controlled Trials
ConclusionAutologous injection of BM-MNC in the setting of AMI may be associated with decreased risk of hospitalization of heart failure in the long term. However, its effect on all-cause mortality and stroke rate is questionable.
Source: Cardiovascular Drugs and Therapy - July 25, 2022 Category: Cardiology Source Type: research
New Approaches for Enhancement of the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Diseases
Tissue Eng Regen Med. 2022 Jul 22. doi: 10.1007/s13770-022-00469-x. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) remain a major health concern worldwide, where mesenchymal stem cells (MSCs) therapy gives great promise in their management through their regenerative and paracrine actions. In recent years, many studies have shifted from the use of transplanted stem cells to their secreted exosomes for the management of various CVDs and cardiovascular-related diseases including atherosclerosis, stroke, myocardial infarction, heart failure, peripheral arterial diseases, and pulmonary hypertension. In different m...
Source: Atherosclerosis - July 22, 2022 Category: Cardiology Authors: Lamiaa Ahmed Khaled Al-Massri Source Type: research
Contemporary Mechanical Circulatory Support With Continuous-Flow Biventricular Assist Devices: A Systematic Review
As the incidence of heart failure increases, so too has that of biventricular failure. While transplantation remains the gold standard therapy for end-stage heart failure, the limited organ supply has increased the need for durable mechanical circulatory support. We therefore sought to conduct a systematic review of continuous-flow ventricular assist devices in a biventricular configuration (CF-BiVAD). An electronic search of PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases was performed using the keyword “BIVAD.” Studies were reviewed to identify discrete variables, including impl...
Source: Cardiology in Review - June 10, 2022 Category: Cardiology Tags: Review Articles Source Type: research
