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Condition: Heart Failure
Nutrition: Herbs
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Total 680 results found since Jan 2013.
Pharmacokinetic evaluation of 24 representative components of Ling-Gui-Zhu-Gan decoction in acute myocardial infarction model rats via a validated ultrahigh-performance liquid chromatography-tandem mass spectrometry method
CONCLUSIONS: The specificity, linearity, precision and accuracy, recovery, matrix effect and stability were validated according to Food and Drug Administration guidance. The validation results demonstrated that the method could be applied to evaluate the pharmacokinetic parameters of LGZGD in AMI rats. The pharmacokinetic parameters showed substantial improvement in quality research of LGZGD, thereby laying the groundwork for preclinical and clinical trials in chronic heart failure clinical efficacy.PMID:37698150 | DOI:10.1002/rcm.9620
Source: Rapid Communications in Mass Spectrometry : RCM - September 12, 2023 Category: Chemistry Authors: Jing Li Ruirui Ge Feng Wang Jinfan Gu Mengyu Zuo Tongjuan Tang Xinru Ge Yingchao Niu Liang Wang Jinling Huang Jian Chen Source Type: research
A new mechanism of therapeutic effect of stachydrine on heart failure by inhibiting myocardial ferroptosis
Eur J Pharmacol. 2023 Jun 27:175881. doi: 10.1016/j.ejphar.2023.175881. Online ahead of print.ABSTRACTFerroptosis is a novel form of programmed cell death caused by iron-dependent lipid peroxidation and excessive production of ROS. Its morphology is characterized by mitochondrial atrophy, increased mitochondrial membrane density, mitochondrial cristae degeneration and rupture, and unchanged nuclear morphology. Here, we investigated whether a bioactive constituent extracted from the Chinese herb Leonurus japonicus Houtt. (Yimucao), stachydrine, could improve cardiac function by inhibiting myocardial ferroptosis. We found si...
Source: European Journal of Pharmacology - June 29, 2023 Category: Drugs & Pharmacology Authors: Yueyang Liang Lei Xia Shuang Lu Songru Yang Shuting Guo Xiaoli Shan Pei Zhao Chen Zhang Wei Guo Ming Xu Huihua Chen Rong Lu Source Type: research
Oxidative stress: roles in skeletal muscle atrophy
Biochem Pharmacol. 2023 Jun 16:115664. doi: 10.1016/j.bcp.2023.115664. Online ahead of print.ABSTRACTOxidative stress, inflammation, mitochondrial dysfunction, reduced protein synthesis, and increased proteolysis are all critical factors in the process of muscle atrophy. In particular, oxidative stress is the key factor that triggers skeletal muscle atrophy. It is activated in the early stages of muscle atrophy and can be regulated by various factors. The mechanisms of oxidative stress in the development of muscle atrophy have not been completely elucidated. This review provides an overview of the sources of oxidative stre...
Source: Biochemical Pharmacology - June 18, 2023 Category: Drugs & Pharmacology Authors: Han Zhang Guangdong Qi Kexin Wang Jiawen Yang Yuntian Shen Xiaoming Yang Xin Chen Xinlei Yao Xiaosong Gu Lei Qi Chun Zhou Hualin Sun Source Type: research
Bioactive Compounds (BACs): A Novel Approach to Treat and Prevent Cardiovascular Diseases
Curr Probl Cardiol. 2023 Feb 23:101664. doi: 10.1016/j.cpcardiol.2023.101664. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs) are one of the leading disorders of serious death and cause huge economic loss to patients and society. It is estimated that about 18 million people have a high death ratio due to the incidence of CVDs such as (stroke, coronary heart disease, and non-ischemic heart failure). Bioactive compounds (BACs) are healthy nutritional ingredients providing beneficial effects and nutritional value to the human body. Epidemiological studies strongly shed light on several bioactive compounds that ar...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Syed Riaz Ud Din Sumbul Saeed Shahid Ullah Khan Mintao Zhong Source Type: research
A four-compound remedy AGILe protected H9c2 cardiomyocytes against oxygen glucose deprivation < em > via < /em > targeting the TNF- α/NF-κB pathway: Implications for the therapy of myocardial infarction
Front Pharmacol. 2023 Jan 13;14:1050970. doi: 10.3389/fphar.2023.1050970. eCollection 2023.ABSTRACTMyocardial infarction (MI) is a highly prevalent and lethal disease worldwide. Prevention and timely recovery are critical for the control of the recurrence and heart failure in MI survivors. The present study was designed to investigate the cardioprotective activity of the herbal medicine formula Baoyuan Decoction (BYD) and identify the active compounds and molecular targets. The ethanolic BYD extract (BYDE) was prepared by water extraction and ethanol precipitation of four herbal medicines, Astragali Radix, Ginseng Radix et...
Source: Atherosclerosis - January 30, 2023 Category: Cardiology Authors: Xiuying Zhang Qilei Chen Jia Zhao Wei Zhao Ni Fan Yu Wang Hubiao Chen Jianhui Rong Source Type: research
Research Progress of Chinese Medicine in the Treatment of Myocardial Ischemia-Reperfusion Injury
Am J Chin Med. 2022 Nov 28:1-17. doi: 10.1142/S0192415X23500015. Online ahead of print.ABSTRACTVascular recanalization is the essential procedure in which severe coronary artery stenosis is diagnosed. However, the blood flow recovery associated with this procedure may cause myocardial ischemia-reperfusion injury (MIRI), which aggravates heart failure. Unfortunately, the mechanism of MIRI has historically been poorly understood. As we now know, calcium overloading, oxidative stress, mitochondrial dysfunction, inflammatory responses, and ferroptosis take part in the process of MIRI. Modern medicine has shown through clinical...
Source: The American Journal of Chinese Medicine - November 28, 2022 Category: Complementary Medicine Authors: Li Dong Zhijie Shen Hao Chi Yingjie Wang Zhaofeng Shi Hongjun Fang Yanling Yang Jingfeng Rong Source Type: research
Results of Novel Clinical Study of Guselkumab and Golimumab Combination Therapy Show Adults with Moderately to Severely Active Ulcerative Colitis Maintained Higher Rates of Clinical, Histologic, and Endoscopic Remission at Week 38
SPRING HOUSE, PENNSYLVANIA, October 10, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from an ongoing analysis of a Phase 2a clinical trial showing adults with moderately to severely active ulcerative colitis (UC) who received 12 weeks of combination induction therapy with guselkumab and golimumab, followed by a transition to guselkumab alone for maintenance, achieved a clinical remission ratea (based on the modified Mayo score [mMayo])b at week 38 of 47.9 percent, a higher rate than induction and maintenance treatment with either guselkumab alone (31.0 percent) or golimumab al...
Source: Johnson and Johnson - October 10, 2022 Category: Pharmaceuticals Source Type: news
Citri Reticulatae Pericarpium (Chenpi): A multi-efficacy pericarp in treating cardiovascular diseases
Biomed Pharmacother. 2022 Sep 1;154:113626. doi: 10.1016/j.biopha.2022.113626. Online ahead of print.ABSTRACTCitri Reticulatae Pericarpium (CRP) has been utilized as a versatile medicinal herb with wide cardiovascular benefits in Asian nations for centuries. Accumulating evidence suggests that CRP and its components are effective in preventing cardiovascular diseases (CVDs) such as atherosclerosis, myocardial infarction, myocardial ischemia, arrhythmia, cardiac hypertrophy, heart failure, and hypertension. Studies show that the two most bioactive components of CRP are flavonoids and volatile oils. The cardiovascular protec...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 4, 2022 Category: Drugs & Pharmacology Authors: Jiami Zou Jiaojiao Wang Weile Ye Jing Lu Chengzhi Li Dongmei Zhang Wencai Ye Suowen Xu Chunbo Chen Peiqing Liu Zhiping Liu Source Type: research
Cardioprotective effect of Chinese herbal medicine for anthracycline-induced cardiotoxicity in cancer patients: A meta-analysis of prospective studies
CONCLUSION: CHM is an effective and safe cardioprotective intervention that can potentially prevent ANT-induced cardiotoxicity. However, due to the insufficient quality of the included trials, our results should be interpreted with cautious.PMID:35905252 | DOI:10.1097/MD.0000000000029691
Source: Cancer Control - July 29, 2022 Category: Cancer & Oncology Authors: Wei Hao You-Yang Shi Yue-Nong Qin Chen-Ping Sun Li-Ying Chen Chun-Yu Wu Yi-Jia Bao Sheng Liu Source Type: research
