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Condition: Brain Tumor

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Total 780 results found since Jan 2013.

Clinical application of perfusion computed tomography in neurosurgery.
Conclusions Perfusion CT provides quantitative and qualitative data that can add diagnostic and prognostic value in a number of neurosurgical disorders, and also help with clinical decision making. With emerging new technical developments in PCT, such as characterization of blood-brain barrier permeability and whole-brain PCT, this technique is expected to provide more and more insight into the pathophysiology of many neurosurgical conditions. PMID: 24266541 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 22, 2013 Category: Neurosurgery Authors: Huang AP, Tsai JC, Kuo LT, Lee CW, Lai HS, Tsai LK, Huang SJ, Chen CM, Chen YS, Chuang HY, Wintermark M Tags: J Neurosurg Source Type: research

Membrane‐type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases
We previously reported that glioma cells induce the expression of membrane‐type 1 metalloproteinase (MT1‐MMP or MMP‐14) in tumor‐associated microglia/macrophages and promote tumor growth, whereas MMP‐14 expression in microglia under physiological conditions is very low. Here, we show that the increase in MMP‐14 expression is also found in microglia/macrophages associated with neurodegenerative and neuroinflammatory pathologies in mouse models as well as in human biopsies or post‐mortem tissue. We found that microglial/macrophage MMP‐14 expression was upregulated in Alzheimer's disease tissue, in active lesi...
Source: Journal of Neuroscience Research - December 10, 2013 Category: Neuroscience Authors: Anika Langenfurth, Jan Leo Rinnenthal, Katyayni Vinnakota, Vincent Prinz, Anne‐Sophie Carlo, Christine Stadelmann, Volker Siffrin, Susann Peaschke, Matthias Endres, Frank Heppner, Rainer Glass, Susanne A. Wolf, Helmut Kettenmann Tags: Research Article Source Type: research

Potential Misdiagnoses of Bell's Palsy in the Emergency Department
Conclusion: Emergency providers have a very low rate of misdiagnosing Bell's palsy. The association between imaging use and misdiagnosis is likely confounded by patient acuity. Increasing age and diabetes are modest risk factors for misdiagnosis.
Source: Annals of Emergency Medicine - July 29, 2013 Category: Emergency Medicine Authors: Jahan Fahimi, Babak B. Navi, Hooman Kamel Tags: Neurology Source Type: research

New Onset Seizures in Elderly:Clinical Presentation and Etiology of First Ever Seizure (P3.235)
CONCLUSIONS: The most common etiology of seizures in elderly was cerebro-vascular disease. Commonest presentation was focal seizureStudy Supported by: nilDisclosure: Dr. Shariff has nothing to disclose. Dr. Alhameed has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shariff, E., Alhameed, M. Tags: Epilepsy and Clinical Neurophysiology: Clinical Manifestations Source Type: research

Efficacy and safety of growth hormone treatment in adults with growth hormone deficiency: a systematic review of studies on morbidity
This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - April 22, 2014 Category: Endocrinology Authors: Christa C. Bunderen, Nadège C. Varsseveld, Eva Marie Erfurth, Johannes C.F. Ket, Madeleine L. Drent Tags: Unsolicited Review Source Type: research

Burden and cost of neurological diseases: a European North–South comparison
ConclusionsHealth expenditure, YLDs, costs and prevalence of neurological conditions were generally not correlated across the eight countries. A clear North–South gradient was found for health expenditures, and partially for YLDs, costs and diseases' prevalence. We hypothesized that this is a consequence of the expansion of morbidity of neurological conditions connected to ageing, that health and welfare systems of selected countries were not prepared to face.
Source: Acta Neurologica Scandinavica - October 23, 2014 Category: Neurology Authors: A. Raggi, M. Leonardi Tags: Original Article Source Type: research

Statins in neurological disorders: An overview and update
Publication date: October 2014 Source:Pharmacological Research, Volume 88 Author(s): Anna Maria Malfitano , Giuseppe Marasco , Maria Chiara Proto , Chiara Laezza , Patrizia Gazzerro , Maurizio Bifulco Statins have, at present, the potential to provide a new therapeutic target for various neurological diseases. It is well established that statins reduce cholesterol levels and prevent coronary heart disease. Moreover, evidence suggest that statins have additional properties such as endothelial protection via action on the nitric oxide synthase system as well as antioxidant, anti-inflammatory and anti-platelet effects. Thes...
Source: Pharmacological Research - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Registration of challenging pre-clinical brain images
Publication date: 30 May 2013 Source:Journal of Neuroscience Methods, Volume 216, Issue 1 Author(s): William R. Crum , Michel Modo , Anthony C. Vernon , Gareth J. Barker , Steven C.R. Williams The size and complexity of brain imaging studies in pre-clinical populations are increasing, and automated image analysis pipelines are urgently required. Pre-clinical populations can be subjected to controlled interventions (e.g., targeted lesions), which significantly change the appearance of the brain obtained by imaging. Existing systems for registration (the systematic alignment of scans into a consistent anatomical coordinate...
Source: Journal of Neuroscience Methods - November 8, 2014 Category: Neuroscience Source Type: research

Cn-15 * adverse effects of bevacizumab in brain tumor patients
CONCLUSION: The range of toxicities was similar to other reports. Interestingly, hypertension was the most common adverse effect and was often not treated. The high incidence of lymphocytopenia may have implications for combination with immunotherapies. These findings underscore the need to develop predictive models to identify patients at high risk for serious treatment-related toxicities.
Source: Neuro-Oncology - November 3, 2014 Category: Cancer & Oncology Authors: Pawar, T., Ladha, H., Mandel, J., Gilbert, M., O'Brien, B., Hamza, M., Armstrong, T. Tags: COMPLICATIONS OF THERAPY AND NEUROTOXICITY Source Type: research

Alexithymia in Neurological Disease: A Review.
Conclusions: Identification of alexithymia could be relevant for prognosis and therapeutic decisions in patients with neurological disease and is certainly worthy of further study. Tools with which to measure alexithymia and delineation from affective disorders and apathy are important methodological issues for future work. PMID: 25658681 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 8, 2015 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Neuropsychiatric disorders among Syrian and Iraqi refugees in Jordan: a retrospective cohort study 2012–2013
Conclusions: Neuropsychiatric disorders, including those traditionally considered outside the purview of refugee health, are an important burden to health among Iraqi and Syrian refugees. Possible interventions could include stroke risk factor reduction and targeted medication donations for multiple sclerosis, epilepsy, and schizophrenia.
Source: Conflict and Health - March 29, 2015 Category: Global & Universal Authors: Erica McKenziePaul SpiegelAdam KhalifaFarrah Mateen Source Type: research

Neuropsychiatric disorders among Syrian and Iraqi refugees in Jordan, 2012-2013: A retrospective, cohort study (P2.324)
CONCLUSIONS:There is a need for long-term planning and financing for neuropsychiatric disorders traditionally considered outside of refugee health. Possible interventions may include stroke risk factor reduction and targeted medication donations for multiple sclerosis, epilepsy, and schizophrenia. Study Supported by: No funding recieved.Disclosure: Dr. McKenzie has nothing to disclose. Dr. Spiegel has nothing to disclose. Dr. Khalifa has nothing to disclose. Dr. Mateen has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: McKenzie, E., Spiegel, P., Khalifa, A., Mateen, F. Tags: Global Neurology Source Type: research

Mortality Predictors in Bacterial Meningitis Patients who developed Hydrocephalus (P5.050)
CONCLUSIONS: In this retrospective analysis, we found that every decade increase in age, ischemic stroke, respiratory failure and requirement of ventriculostomy were significant predictors of mortality in patients of bacterial meningitis who developed hydrocephalus. Study Supported by:Disclosure: Dr. Irshad has nothing to disclose. Dr. Modi has nothing to disclose. Dr. Naqvi has nothing to disclose. Dr. Dharaiya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Irshad, K., Modi, S., Naqvi, I., Dharaiya, D. Tags: Neuroepidemiology: Headache, Global Health, and Infectious Disease Source Type: research

Hacking The Nervous System
(Photo: © Job Boot) One nerve connects your vital organs, sensing and shaping your health. If we learn to control it, the future of medicine will be electric.When Maria Vrind, a former gymnast from Volendam in the Netherlands, found that the only way she could put her socks on in the morning was to lie on her back with her feet in the air, she had to accept that things had reached a crisis point. “I had become so stiff I couldn’t stand up,” she says. “It was a great shock because I’m such an active person.”It was 1993. Vrind was in her late 40s and working two jobs, athletics coach and a carer for disabled ...
Source: Science - The Huffington Post - May 30, 2015 Category: Science Source Type: news