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MiR-1908 improves cardiac fibrosis after myocardial infarction by targeting TGF- β1.
CONCLUSIONS: MiR-1908 can improve the myocardial fibrosis through the target gene TGF-β1. PMID: 29687863 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 26, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

MicroRNA-298 regulates apoptosis of cardiomyocytes after myocardial infarction.
CONCLUSIONS: MiR-298 can improve the myocardial apoptosis through the target gene BAX. PMID: 29424914 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 11, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

A positive feedback loop between IL-1 β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages.
A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages. Vascul Pharmacol. 2018 Jan 22;: Authors: Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D Abstract Inflammation plays an important role in atherosclerosis, a notion supported by the beneficial effects of the IL-1β inhibitor canakinumab in the CANTOS trial. Sialic acids (Sias), components of the surface glycocalyx, regulate intercellular and intermolecular interactions. We investigated ...
Source: Vascular Pharmacology - January 22, 2018 Category: Drugs & Pharmacology Authors: Sieve I, Ricke-Hoch M, Kasten M, Battmer K, Stapel B, Falk CS, Leisegang MS, Haverich A, Scherr M, Hilfiker-Kleiner D Tags: Vascul Pharmacol Source Type: research

Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1 α/CXCR4 axis.
Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis. Eur J Pharmacol. 2017 Aug 29;: Authors: Yin Y, Duan J, Guo C, Wei G, Wang Y, Guan Y, Mu F, Yao M, Xi M, Wen A Abstract The present study was performed to investigate the the potential role of Danshensu in therapeutic angiogenesis in ischemic myocardium and endothelial progenitor cells (EPCs) function. The rat model of myocardial infarction (MI) injury was induced by left anterior descending coronary artery ligation for 14 days. Danshensu signific...
Source: European Journal of Pharmacology - August 29, 2017 Category: Drugs & Pharmacology Authors: Yin Y, Duan J, Guo C, Wei G, Wang Y, Guan Y, Mu F, Yao M, Xi M, Wen A Tags: Eur J Pharmacol Source Type: research

LncRNA MIAT enhances cardiac hypertrophy partly through sponging miR-150.
CONCLUSIONS: MIAT is significantly increased in Ang II induced cardiac hypertrophy and contributes to the pathological development. MIAT can suppress miR-150 expression in cardiomyocytes and miR-150 is a downstream effector of MIAT in the development of cardiac hypertrophy. PMID: 27649667 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - September 23, 2016 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Nanocarriers Assisted siRNA Gene Therapy for the Management of Cardiovascular Disorders.
This article reviews the application of siRNA against CVDs with special emphasis on gene targets in combination with delivery systems such as cationic hydrogels, polyplexes, peptides, liposomes and dendrimers. PMID: 26471319 [PubMed - in process]
Source: Current Pharmaceutical Design - October 18, 2015 Category: Drugs & Pharmacology Authors: Maheshwari R, Tekade M, Sharma PA, Tekade RK Tags: Curr Pharm Des Source Type: research

Deoxycholic acid-modified polyethylenimine based nanocarriers for RAGE siRNA therapy in acute myocardial infarction.
Abstract The activation of receptor for advanced glycation end products (RAGE) signaling is mainly associated with myocardial ischemia/reperfusion injury. Thus the blockade of RAGE-ligands axis can be considered as a potential therapeutic strategy to protect myocardial infarction after ischemia/reperfusion injury. Herein, we strengthened the cardioprotective effect with combinatorial treatment of soluble RAGE (sRAGE) and RAGE siRNA (siRAGE) causing more effective suppression of RAGE-mediated signaling transduction. For pharmacological blockade of RAGE, sRAGE, the extracellular ligand binding domain of RAGE, acts a...
Source: Archives of Pharmacal Research - January 6, 2015 Category: Drugs & Pharmacology Authors: Ku SH, Hong J, Moon H, Jeong JH, Mok H, Park S, Choi D, Kim SH Tags: Arch Pharm Res Source Type: research

COX-2 Signaling and Cancer: New Players in Old Arena.
Abstract Cancer is a leading cause of death worldwide. The expression of COX-2 and prostaglandins has not only been associated with various types of cancer but is also directly proportional to their aggressiveness including metastasis. Thus, inhibition of COX-2 activity has been one of the preferred targets for cancer reduction. Broad spectrum inhibition of all forms of COX (using NSAIDs) is associated with various side effects ranging from gastric ulceration to renal problems. Even specific COX-2 inhibitors (COXIBS) are associated with side effects like myocardial infarction. Alternative strategies including siRN...
Source: Current Drug Targets - January 26, 2014 Category: Drugs & Pharmacology Authors: Misra S, Sharma K Tags: Curr Drug Targets Source Type: research

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