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Cow's milk allergy
Purpose of review To highlight the most recent insights on cow's milk allergy (CMA), its treatment, and management. Recent findings CMA is one of the most common food allergies among children. Burdened by the risk for fatal reaction, CMA may imply also a severe impairment of health-related quality of life at individual and family level as well as well as individual and societal costs. The updated Diagnosis and Rationale for Action against Cow's Milk Allergy series is going to provide a series of manuscripts that will offer a comprehensive state-of-the-art specifically on CMA, including international evidence-bas...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

M557 successful treatment and complete steroid sparing using omalizumab in bullous pemphigoid masquerading as refractory urticaria
The classic form of bullous pemphigoid (BP) presents with widespread tense bullae; however, early presentations of BP can be non-specific: pruritus alone, eczema, or urticaria. Prednisone is the typical first-line treatment for extensive disease. Traditionally, IgG autoantibodies against hemidesmosome components were the focus of this condition, but more recently, the pathogenicity of IgE autoantibodies has emerged and its blockade as a therapeutic target using omalizumab has been successfully described.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2020 Category: Allergy & Immunology Authors: H. Pham, D. Lanoue, J. Valois, W. Yang Source Type: research

Omalizumab in three children with severe vernal keratoconjunctivitis
ConclusionAlthough the clinical benefit of omalizumab in asthma and chronic spontaneous urticaria (CSU) has been established in several clinical trials, there are very little data about its effect on severe VKC. In addition to few previously reported cases we can report the rapid effectiveness of omalizumab in VKC clinically and in terms of quality of life. Randomized trials are needed to include omalizumab in third-line treatment of VKC for prevention of visual impairment and further sequelae such as corneal damage.
Source: Allergo Journal International - May 25, 2020 Category: Allergy & Immunology Source Type: research

The Severe Asthma Network in Italy: Findings and Perspectives
ConclusionsThis study revealed a high frequency of relevant comorbidities and that a substantial proportion of patients have late-onset asthma; all these features define specific different disease phenotypes. Severe asthma complexity and comorbidities require multidisciplinary approaches, led by specifically trained pulmonologists and allergists.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 9, 2019 Category: Allergy & Immunology Source Type: research

The Severe Asthma Network in Italy (SANI): findings and perspectives
ConclusionsThis study revealed a high frequency of relevant comorbidities and that a substantial proportion of patients have a late-onset asthma; all these features define specific different disease phenotypes. Severe asthma complexity and comorbidities require multidisciplinary approaches, led by specifically trained Pulmonologists and Allergists.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 25, 2018 Category: Allergy & Immunology Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research