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Specialty: Geriatrics
Condition: Dementia

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Total 327 results found since Jan 2013.

Risk Factors Associated With Cognitive, Functional, and Behavioral Trajectories of Newly Diagnosed Dementia Patients
Conclusions: Sociodemographic characteristics and clinical comorbidities predict cognitive and functional changes. Only cognitive status explains behavioral decline. Results provide an understanding of the characteristics that impact cognitive, functional, and behavioral decline.
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - January 12, 2017 Category: Geriatrics Authors: Jutkowitz, E., MacLehose, R. F., Gaugler, J. E., Dowd, B., Kuntz, K. M., Kane, R. L. Tags: Research Article Source Type: research

Interaction of obstructive sleep apnoea and cognitive impairment with slow gait speed in middle-aged and older adults
Conclusionwe found that the inverse association between the time taken to walk 4 m and a cognitive score became significantly stronger, if an individual had OSA.
Source: Age and Ageing - January 7, 2017 Category: Geriatrics Source Type: research

Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals
ConclusionIn routine primary care, SBP less than 135 mmHg was associated with greater mortality in the oldest adults with hypertension and free of selected potentially confounding comorbidities. Although important confounders were accounted for, observational studies cannot exclude residual confounding. More work is needed to establish whether unplanned SBPs less than 135 mmHg in older adults with hypertension may be a useful clinical sign of poor prognosis, perhaps requiring clinical review of overall care.
Source: Journal of the American Geriatrics Society - December 29, 2016 Category: Geriatrics Authors: Jo ão Delgado, Jane A.H. Masoli, Kirsty Bowman, W. David Strain, George A. Kuchel, Kate Walters, Louise Lafortune, Carol Brayne, David Melzer, Alessandro Ble, Tags: Clinical Investigation Source Type: research

Continued Use of Warfarin in Veterans with Atrial Fibrillation After Dementia Diagnosis
ConclusionDiscontinuing warfarin after a diagnosis of dementia is associated with a significant increase in stroke and mortality.
Source: Journal of the American Geriatrics Society - December 29, 2016 Category: Geriatrics Authors: Ariela R. Orkaby, Al Ozonoff, Joel I. Reisman, Donald R. Miller, Shibei Zhao, Adam J. Rose Tags: Clinical Investigations Source Type: research

Use of Oral Anticoagulant Therapy in Older Adults with Atrial Fibrillation After Acute Ischemic Stroke
ConclusionDespite very high stroke risk, more than 40% of participants were not discharged with an OAC. Dominant reasons included fall risk, poor prognosis, older age, and dementia. These individuals’ high 1‐year mortality rate confirmed their high level of comorbidity. To improve anticoagulation decisions and outcomes in this population, future research should focus on strategies to mitigate fall risk, improve assessment of risks and benefits of anticoagulation in individuals with AF, and determine whether newer anticoagulants are safer in complex elderly and frail individuals.
Source: Journal of the American Geriatrics Society - December 29, 2016 Category: Geriatrics Authors: Emer R. McGrath, Alan S. Go, Yuchiao Chang, Leila H. Borowsky, Margaret C. Fang, Kristi Reynolds, Daniel E. Singer Tags: Clinical Investigation Source Type: research

Calcium supplements linked to dementia risk in women with certain health conditions, Alzheimer ’s Society comment
New research claims that calcium supplements may be associated with an increased risk of dementia in older women who have had a stroke or other signs of cerebrovascular disease.
Source: Alzheimers Society - December 23, 2016 Category: Geriatrics Source Type: news

Memory performance on the story recall test and prediction of cognitive dysfunction progression in mild cognitive impairment and Alzheimer's dementia
ConclusionsThe present study suggests that the SRT delayed recall score independently predicts progression to dementia in patients with MCI. Geriatr Gerontol Int 2016; ••: ••–••.
Source: Geriatrics and Gerontology International - November 30, 2016 Category: Geriatrics Authors: Jong ‐Hwan Park, Hyuntae Park, Sang Wuk Sohn, Sungjae Kim, Kyung Won Park Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Magnetic Resonance Volumetry: Prediction of Subjective Memory Complaints and Mild Cognitive Impairment, and Associations with Genetic and Cardiovascular Risk Factors
Conclusions: Fully automated MR volumetry can distinguish subjects with SMC and MCI from controls in a general population, but insuf ficiently to assume a clear clinical role. Research on sporadic LOAD might benefit from a sex-specific search for genetic risk factors.Dement Geriatr Cogn Disord Extra 2016;6:529 –541
Source: Dementia and Geriatric Cognitive Disorders Extra - November 25, 2016 Category: Geriatrics Source Type: research

Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: The Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi ‐Inflammatory Biomarkers
ConclusionAdding oxi‐inflammatory load to cardiovascular risk scores may be useful for determining risk of cognitive impairment in very old adults.
Source: Journal of the American Geriatrics Society - November 13, 2016 Category: Geriatrics Authors: Stephanie L. Harrison, Anton J. M. Craen, Ngaire Kerse, Ruth Teh, Antoneta Granic, Karen Davies, Keith A. Wesnes, Wendy P. J. Elzen, Jacobijn Gussekloo, Thomas B. L. Kirkwood, Louise Robinson, Carol Jagger, Mario Siervo, Blossom C. M. Stephan Tags: Clinical Investigations Source Type: research

N ‐terminal pro‐brain natriuretic peptide is a useful marker to identify latent heart failure patients in older adults in a rural outpatient clinic
ConclusionsA large number of elderly patients without a diagnosis of HF who were attending an outpatient clinic showed high levels of NT‐proBNP, and measurement of NT‐proBNP is useful to identify patients with latent HF. Geriatr Gerontol Int 2016; ••: ••–••.
Source: Geriatrics and Gerontology International - October 31, 2016 Category: Geriatrics Authors: Kosuke Hamagawa, Toru Kubo, Kotaro Nishimura, Yuichi Baba, Takayoshi Hirota, Naohito Yamasaki, Hiroaki Kitaoka Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

DNP, mitochondrial uncoupling, and neuroprotection: A Little Dab'll Do Ya
Publication date: Available online 4 September 2016 Source:Alzheimer's & Dementia Author(s): John G. Geisler, Krisztina Marosi, Joshua Halpern, Mark P. Mattson Recent findings have elucidated roles for mitochondrial uncoupling proteins (UCPs) in neuronal plasticity and resistance to metabolic and oxidative stress. UCPs are induced by bioenergetic challenges such as caloric restriction and exercise and may protect neurons against dysfunction and degeneration. The pharmacological uncoupler 2,4-dinitrophenol (DNP), which was once prescribed to >100,000 people as a treatment for obesity, stimulates several adap...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - September 3, 2016 Category: Geriatrics Source Type: research

Calcium supplements linked to dementia risk in women with certain health conditions, Alzheimer ’s Society comment
New research claims that calcium supplements may be associated with an increased risk of dementia in older women who have had a stroke or other signs of cerebrovascular disease.
Source: Alzheimers Society - August 17, 2016 Category: Geriatrics Source Type: news

Acute coronary syndrome in elderly – What is the place for invasive strategy?
Conclusion In elderly patients with ACS, an invasive strategy was associated with short and long-term survival advantage. The predictors for invasive intervention are STEMI, previous PCI, sinus rhythm and haemoglobin at admission.
Source: European Geriatric Medicine - August 16, 2016 Category: Geriatrics Source Type: research

METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research
Publication date: Available online 1 August 2016 Source:Alzheimer's & Dementia Author(s): METACOHORTS Consortium Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research still focuses on pure Alzheimer's disease. An improved understanding of the vascular contributions to neurodegeneration and dementia, particularly by small vessel disease, is hampered by imprecise data, including the incidence and prevalence of symptomatic and clinicall...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - August 2, 2016 Category: Geriatrics Source Type: research

Attitudes of neurology specialists toward older adults.
CONCLUSIONS: Generalization of geriatrics education may translate into a better understanding and improved care for older patients. Development of instruments and implementation of qualitative studies to assess attitudes of neurologists toward older adults are needed. PMID: 27456680 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - July 24, 2016 Category: Geriatrics Authors: Seferoğlu M, Yıldız D, Pekel NB, Güneş A, Yıldız A, Tufan F Tags: Aging Clin Exp Res Source Type: research