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Specialty: Neuroscience
Condition: Dementia

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Total 167 results found since Jan 2013.

Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion
g & Sookja K Chung
Source: Journal of Cerebral Blood Flow and Metabolism - September 30, 2015 Category: Neuroscience Authors: Victor K L HungPatrick K K YeungAngela K W LaiMaggie C Y HoAmy C Y LoKevin C ChanEd X K WuStephen S M ChungChi W CheungSookja K Chung Tags: Alzheimer’s disease amyloidosis astrocytes endothelin-1 ischemic stroke Source Type: research

A Scoping Review of the Incidence, Predictors, and Outcomes of Delirium Among Critically Ill Stroke Patients
CONCLUSIONS: Current findings are limited by heterogenous populations, assessments, and measurement parameters. Detection and management of delirium among critically ill stroke patients requires an approach with specific considerations to the complexities of acute neurological injury and concomitant critical illness.
Source: Journal of Neuroscience Nursing - May 13, 2022 Category: Neuroscience Tags: Articles Source Type: research

The Effect of an Educational Pamphlet on Patient Knowledge of and Intention to Discuss Screening for Obstructive Sleep Apnea in the Acute Ischemic Stroke Population
Conclusions: A brief educational pamphlet written using health literacy concepts was considered valuable and improved patient knowledge and intention to discuss OSA screening with a physician. Further work is needed to determine whether the pamphlet can promote a discussion and referral for OSA screening at the primary care level.
Source: Journal of Neuroscience Nursing - May 5, 2018 Category: Neuroscience Tags: Article Source Type: research

Sleep Apnea Is a Risk Factor for Stroke and Vascular Dementia
AbstractPurpose of ReviewIn this article, we review the cerebrovascular complications of sleep apnea (SA). SA is the major sleep disorder associated with stroke and vascular dementia.Recent FindingsSleep apnea syndrome of moderate to severe intensity affects 17% of 50 –70-year-old men and 9% of 50–70-year-old women, making SA a notorious and prevalent disorder. SA increases the risk of hypertension, stroke, myocardial infarction, and atrial fibrillation (AF) and is closely linked to vascular dementia. In addition, SA may worsen the neurologic outcome in acute stroke patients and interferes with rehabilitation after str...
Source: Current Neurology and Neuroscience Reports - June 25, 2018 Category: Neuroscience Source Type: research

Clinical characteristics and treatment outcomes among stroke patients hospitalized to Nekemte referral hospital, western Ethiopia
ConclusionAbout two third of the patients had poor treatment outcome. Educational status and mean length of hospital stays were independent predictors of poor treatment out-comes. An emergency care setup capable of early patient evaluation, identification and management of stroke complications is crucial to overcome early stroke related mortality.
Source: Journal of Clinical Neuroscience - January 25, 2020 Category: Neuroscience Source Type: research

Comorbid Aβ toxicity and stroke: hippocampal atrophy, pathology, and cognitive deficit
Abstract: Numerous clinical and epidemiological reports indicate that patients with history of vascular illness such as stroke are more likely to develop dementia as the clinical manifestation of Alzheimer's disease. However, there are little data regarding the pathologic mechanisms that link vascular risk factors to the factors associated with dementia onset. We provide evidence that suggests intriguing detrimental interactions between stroke and β-amyloid (Aβ) toxicity in the hippocampus. Stroke was induced by unilateral striatal injection of endothelin-1, the potent vasoconstrictor. Aβ toxicity was modeled by bilater...
Source: Neurobiology of Aging - January 10, 2014 Category: Neuroscience Authors: Zareen Amtul, Simona Nikolova, Lulu Gao, Robin J. Keeley, John F. Bechberger, Alicia L. Fisher, Robert Bartha, David G. Munoz, Robert J. McDonald, Christian C. Naus, J. Martin Wojtowicz, Vladimir Hachinski, David F. Cechetto Tags: Regular Articles Source Type: research

Post-Stroke Cognitive Impairment: A Review Focusing on Molecular Biomarkers
AbstractPost-stroke cognitive impairment (PSCI), as one of the major complications after stroke, refers to a series of syndromes from mild cognitive impairment to dementia caused by stroke. Stroke has been reported to increase the risk of cognitive impairment by at least five to eight times. The assessment of PSCI usually relies on neuropsychological tests, but the results of these tests are subjective and inaccurate, and can be insufficient for the diagnosis and prognosis of PSCI. In recent years, an increasing number studies have indicated that changes in the expression of biomarkers such as C-reactive protein (CRP), int...
Source: Journal of Molecular Neuroscience - March 25, 2020 Category: Neuroscience Source Type: research

Is Matrix Metalloproteinase-9 Associated with Post-Stroke Cognitive Impairment or Dementia?
CONCLUSIONS: MMP-9 level and MMP-9 rs3918242 polymorphism have an important role in the occurrence and development of post-stroke cognitive impairment or dementia (PSCID).PMID:36424752 | DOI:10.31083/j.jin2106160
Source: Journal of Integrative Neuroscience - November 25, 2022 Category: Neuroscience Authors: Jianhua Zhao Fangli Yang Xue Peng Qing Li Fan Wang Zhixiu Xu Ruiyan Cai Danxia Ji Jian Zhang Minghua Wang Qiong Li Sibei Ji Shaomin Li Source Type: research