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Condition: Liver Disease
Drug: Lortab

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Total 95 results found since Jan 2013.

Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect How to Construct Measures of Biological Age A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome Intestinal Barrier Dysfunction as a Feature of Aging in Many Species NAFLD as an Age-Related Condition Towards Sensory Hair Cell Regeneration in the Inner Ear Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Absence of Increased Susceptibility to Acetaminophen-Induced Liver Injury in a Diet-Induced NAFLD Mouse Model
Toxicol Pathol. 2023 May 9:1926233231171101. doi: 10.1177/01926233231171101. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease and its influence on drug-induced liver injury (DILI) is not fully understood. We investigated whether NAFLD can influence acetaminophen (APAP [N-acetyl-p-aminophenol])-induced hepatotoxicity in a diet-induced obese (DIO) mouse model of NAFLD. The male C57BL/6NTac DIO mice, fed a high-fat diet for more than 12 weeks, developed obesity, hyperinsulinemia, impaired glucose tolerance, and hepatomegaly with hepatic steatosis, similar to human NAFLD....
Source: Toxicologic Pathology - May 9, 2023 Category: Pathology Authors: Takeshi Izawa Gregory S Travlos Ricardo A Cortes Natasha P Clayton Robert C Sills Arun R Pandiri Source Type: research

miR-194 upregulates CYP7A1 expression via β-catenin signaling and aggravates cholestatic liver diseases
In conclusion, the results suggest that the loss of miR-194 ameliorates cholestatic liver injury and may suppress CYP7A1 expression via activation of CTNNB1 signaling.PMID:36868469 | DOI:10.1016/j.ajpath.2023.02.007
Source: Am J Pathol - March 3, 2023 Category: Pathology Authors: Po-Chun Chen Chien-Peng Hsu Sheng-Ya Wang Tsai-Yen Wu Yu-Jyun Lin You-Tzung Chen Shu-Hao Hsu Source Type: research

Real-World Hepatic Safety of Oral Acetaminophen versus Loxoprofen/Celecoxib: Using a Nationwide Electronic Medical Record Database
In conclusion, the non-inferiority of acetaminophen to loxoprofen and celecoxib in terms of the risk of liver injury in clinical practice was inconclusive in this study. This article is protected by copyright. All rights reserved.PMID:36841952 | DOI:10.1002/jcph.2216
Source: The Journal of Clinical Pharmacology - February 26, 2023 Category: Drugs & Pharmacology Authors: Yasuyuki Okumura Takeshi Kimura Shoichiro Inokuchi Masahiro Okamoto Toshio Takano Masumi Miyake Yuji Kumagai Source Type: research

Drug induced liver injury: causative agents and predictors for the outcome - a retrospective study at Tanta University Hospital, Egypt
CONCLUSIONS: Drug induced liver injury is an important health problem in Egypt. Further studies are needed to know the natural history of this disorder. Acetaminophen is one of the most common leading causes. The MELD score is a useful predictor of the outcome of drug induced liver injury such as fulminant hepatic failure and mortality.PMID:36734717 | DOI:10.26355/eurrev_202301_31057
Source: Pharmacological Reviews - February 3, 2023 Category: Drugs & Pharmacology Authors: N E Helal M Elkadeem S M Elbastawesy S A Mashaal Source Type: research

Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway
Int Immunopharmacol. 2023 Jan;114:109558. doi: 10.1016/j.intimp.2022.109558. Epub 2022 Dec 21.ABSTRACTThe overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can alleviate liver damage by scavenging reactive oxygen species (ROS). Evidence suggests that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated pyroptosis is involved in the development of NAFLD. Moreover, thioredoxin-interactive protein (TXNIP) activation is a key event linking ROS to NLRP3 infl...
Source: International Immunopharmacology - January 26, 2023 Category: Allergy & Immunology Authors: Xiangfu Jiang Yu Li Dongdong Fu Tingyu You Shuai Wu Jiao Xin Jiagen Wen Yan Huang Chengmu Hu Source Type: research

Caveolin-1 alleviates acetaminophen-induced vascular oxidative stress and inflammation in non-alcoholic fatty liver disease
In conclusion, our findings confirmed that CAV1 exerts a protective effect against vascular injury by inhibiting oxidative stress and inflammation through the PKC/MAPK pathway. Therefore, restoration of CAV1 may have clinical benefits in reducing APAP-induced vascular damage in NAFLD patients.PMID:36596386 | DOI:10.1016/j.freeradbiomed.2022.12.095
Source: Free Radical Biology and Medicine - January 3, 2023 Category: Biology Authors: Dongdong Fu Shuai Wu Xiangfu Jiang Tingyu You Yu Li Jiao Xin Xiaowen Feng Jiagen Wen Yan Huang Chengmu Hu Source Type: research