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Astragalin ameliorates renal injury in diabetic mice by modulating mitochondrial quality control via AMPK-dependent PGC1 α pathway
In this study, we investigated the therapeutic effects of AG against renal injury in streptozocin (STZ)-induced diabetic mouse model. Diabetic mice were orally administered AG (5, 10 mg·kg-1·d-1) for 4 weeks. We showed that AG treatment greatly improved the proteinuria and ameliorated renal pathological damage without affecting the elevated blood glucose in diabetic mice. Furthermore, AG treatment significantly suppressed highly activated ALR2, and reduced oxidative stress in the kidney of diabetic mice and in high glucose and lipids-stimulated HK2 cells in vitro. We demonstrated that AG treatment modulated mitochondrial...
Source: Acta Pharmacologica Sinica - March 1, 2023 Category: Drugs & Pharmacology Authors: Meng-Yao Sun Hui-Jing Ye Chen Zheng Zi-Jie Jin Yan Yuan Hong-Bo Weng Source Type: research

Ablation of shank1 protects against 6-OHDA-induced cytotoxicity via PRDX3-mediated inhibition of ER stress in SN4741 cells
CONCLUSION: In summary, the present study has provided the first evidence that the knockdown of shank1 protects against 6-OHDA-induced ER stress and mitochondrial dysfunction through activating the PRDX3 pathway.PMID:36797610 | DOI:10.2174/1871527322666230216124156
Source: CNS and Neurological Disorders Drug Targets - February 16, 2023 Category: Drugs & Pharmacology Authors: Ye-Ping Xu Jing Zhang Xue Mei Yan Wu Wei Jiao Yu-Hai Wang Ai-Qin Zhang Source Type: research

Autophagy-dependent Na < sup > + < /sup > -K < sup > + < /sup > -ATPase signalling and abnormal urate reabsorption in hyperuricaemia-induced renal tubular injury
In this study, we investigated whether autophagy plays a key role in the NKA impairment signalling and increased urate reabsorption in HUA-induced renal tubular injury. Protein spectrum analysis of exosomes from the urine of HUA patients revealed the activation of lysosomal processes, and exosomal expression of lysosome membrane protein 2 was associated with increased serum levels and decreased renal urate excretion in patients. We demonstrated that high uric acid (UA) induced lysosome dysfunction, autophagy and inflammation in a time- and dose-dependent manner and that high UA and/or NKA α1 siRNA significantly increased ...
Source: European Journal of Pharmacology - September 5, 2022 Category: Drugs & Pharmacology Authors: Haochen Guan Huagang Lin Xiaojun Wang Ying Xu Yuqi Zheng Xun Zhou Xuehong Diao Zhibin Ye Jing Xiao Source Type: research

Oroxylin A ameliorates AKI-to-CKD transition through maintaining PPAR α-BNIP3 signaling-mediated mitochondrial homeostasis
Conclusion: Our findings revealed that OA ameliorates AKI-to-CKD transition by maintaining mitochondrial homeostasis through inducing PPARα-BNIP3 signaling pathway, indicating that OA may serve as a candidate therapeutic strategy for alleviating AKI and CKD.
Source: Frontiers in Pharmacology - August 23, 2022 Category: Drugs & Pharmacology Source Type: research

NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species
This study demonstrates a novel role for epithelial cell NOX4 in accelerating lung epithelial cell apoptosis from HALI. Deletion of the Nox4 gene in AT2 cells or silencing NOX4 in lung epithelial cells protected the lungs from severe HALI with reduced apoptosis and decreased mt ROS production in HO. These results suggest NOX4 as a potential target for the treatment of HALI.
Source: Frontiers in Pharmacology - May 19, 2022 Category: Drugs & Pharmacology Source Type: research

Galanin Regulates Myocardial Mitochondrial ROS Homeostasis and Hypertrophic Remodeling Through GalR2
The regulatory peptide galanin is broadly distributed in the central nervous systems and peripheral tissues where it modulates numerous physiological and pathological processes through binding to its three G-protein-coupled receptors, GalR1-3. However, the function and identity of the galaninergic system in the heart remain unclear. Therefore, we investigated the expression of the galanin receptors in cardiac cells and tissues and found that GalR2 is the dominant receptor subtype in adult mouse hearts, cardiomyocytes and H9C2 cardiomyoblasts. In vivo, genetic suppression of GalR2 promotes cardiac hypertrophy, fibrosis and ...
Source: Frontiers in Pharmacology - March 31, 2022 Category: Drugs & Pharmacology Source Type: research

Mitochondria-Targeted CoQ < sub > 10 < /sub > Loaded PLGA-b-PEG-TPP Nanoparticles: Their Effects on Mitochondrial Functions of COQ8B < sup > -/- < /sup > HK-2 cells
Eur J Pharm Biopharm. 2022 Feb 26:S0939-6411(22)00039-X. doi: 10.1016/j.ejpb.2022.02.018. Online ahead of print.ABSTRACTCoenzyme Q10 (CoQ10) deficiency exhibits signs of multiple organ dysfunctions, particular subtypes present isolated kidney involvement progressing to chronic kidney disease. In these patients, early administration of oral CoQ10 has been shown to decrease proteinuria and to delay development of chronic kidney disease, which suggests that it may have a renoprotective potential in these patients. However, CoQ10 bioavailability in mitochondria is low, therefore its efficacy is limited. We aimed to develop mit...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 1, 2022 Category: Drugs & Pharmacology Authors: Hamide Sena Ozbay Samiye Yabanoglu-Ciftci Ipek Baysal Merve Gultekinoglu Cemil Can Eylem Kezban Ulubayram Emirhan Nemutlu Rezan Topaloglu Fatih Ozaltin Source Type: research

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