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Stepping up our game with secondary immune deficiency
Pharmacologic immune suppression in the past was dirty. I imagine many readers of this journal remember days when systemic corticosteroids were pretty much the only medication they had to effectively treat asthma and rheumatologic diseases. Fortunately, as the management of inflammatory and autoimmune conditions has been refined over the past few decades, our reliance on broad immune suppressants has decreased. Although we still have our “old faithful” prednisone to fall back on, we can now use more targeted therapies to improve outcomes.
Source: Annals of Allergy, Asthma and Immunology - June 1, 2023 Category: Allergy & Immunology Authors: Jay A. Lieberman Tags: Editorial Source Type: research

Airway autoantibodies are determinants of asthma severity
Conclusion We report 55% of moderate–severe asthmatic patients to have airway autoreactivity that persists despite anti-inflammatory treatment and is associated with exacerbations.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Salter, B., Zhao, N., Son, K., Tan, N. S., Dvorkin-Gheva, A., Radford, K., LaVigne, N., Huang, C., Kjarsgaard, M., Li, Q.-Z., Tselios, K., Lim, H. F., Khalidi, N., Nair, P., Mukherjee, M. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Alopecia Areata: an Update on Etiopathogenesis, Diagnosis, and Management
AbstractAlopecia areata (AA) is a common chronic tissue-specific autoimmune disease, resulting in hair loss, that affects up to 2% of the general population. The exact pathobiology of AA has still remained elusive, while the common theory is the collapse of the immune privilege of the hair follicle caused by immunological mechanism. Multiple genetic and environment factors contribute to the pathogenesis of AA. There are several clinical treatments for AA, varying from one or multiple well-defined patches to more diffuse or total hair loss of the scalp (alopecia totalis) or hair loss of the entire body (alopecia universalis...
Source: Clinical Reviews in Allergy and Immunology - August 17, 2021 Category: Allergy & Immunology Source Type: research

Comparison of Guidelines for Management of Pemphigus: a Review of Systemic Corticosteroids, Rituximab, and Other Immunosuppressive Therapies
AbstractPemphigus is a severe autoimmune bullous dermatosis that affects the skin and/or mucosa, and it may be life-threatening without proper treatment. The guidelines and/or consensus statements for treatment vary widely between groups. We selected 6 guidelines and consensus statements established by different associations about the management of pemphigus vulgaris (PV) and/or pemphigus foliaceus (PF) to review, compare, and contrast the similarities and differences of these recommendations and provide optimal management suggestions to physicians. Corticosteroids remain a first-line therapy for pemphigus, but there are m...
Source: Clinical Reviews in Allergy and Immunology - August 4, 2021 Category: Allergy & Immunology Source Type: research

Oral selenium improved the disease activity in patients with mild Graves' orbitopathy
CONCLUSIONS: This is the first study in a Mexican population demonstrating that oral selenium decreases clinical activity and stops progression in patients with mild GO.PMID:33863564 | DOI:10.1016/j.jfo.2020.08.029
Source: Journal Francais d Ophtalmologie - April 17, 2021 Category: Opthalmology Authors: M Almanza-Monterrubio L Garnica-Hayashi A D ávila-Camargo Á Nava-Castañeda Source Type: research

COVID-19 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases: Clinical Guidance of the Korean College of Rheumatology
J Korean Med Sci. 2021 Mar 29;36(12):e95. doi: 10.3346/jkms.2021.36.e95.ABSTRACTThe coronavirus disease 2019 (COVID-19) pandemic has caused more than 100 million infections and 2 million deaths worldwide. In up to 20% of cases, COVID-19 infection can take a severe, life-threatening course. Therefore, preventive measures such as mask-wearing, hand hygiene, and social distancing are important. COVID-19 vaccines that use novel vaccine technology can prevent up to 95% of infections. However, the uncertainty regarding the efficacy and safety of vaccination in patients with autoimmune inflammatory rheumatic disease (AIIRD), who ...
Source: Journal of Korean Medical Science - March 30, 2021 Category: Biomedical Science Authors: Jin Kyun Park Eun Bong Lee Kichul Shin Yoon Kyoung Sung Tae Hwan Kim Seong Ryul Kwon Myeung Su Lee Seung Jae Hong Byoong Yong Choi Shin Seok Lee Han Joo Back Korean College of Rheumatology Task Force for COVID-19 Vaccine Guidance for Patients with Autoimm Source Type: research

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