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Condition: Diabetes Type 2
Drug: Melatonin
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Total 103 results found since Jan 2013.
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Melatonin attenuates lung ischemia-reperfusion injury through SIRT3 signaling-dependent mitophagy in type 2 diabetic rats
Conclusion: Data indicated that melatonin attenuates diabetic LIRI through activation of SIRT3 signaling-mediated mitophagy.PMID:37265380 | DOI:10.1080/01902148.2023.2213335
Source: Cell Research - June 2, 2023 Category: Cytology Authors: Zhiqiang Song Congmin Yan Yuanbo Zhan Qiujun Wang Yina Zhang Tao Jiang Source Type: research
Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families
CONCLUSIONS: This is the first study to report MTNR1A as a novel risk gene in T2D. Functional studies are needed to confirm these results.PMID:37259752 | DOI:10.26355/eurrev_202305_32480
Source: Pharmacological Reviews - June 1, 2023 Category: Drugs & Pharmacology Authors: M Amin C Gragnoli Source Type: research
Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal the Protective Mechanisms of Polygonatum Sibiricum Polysaccharide on Type 2 Diabetes Mellitus Model Rats
CONCLUSION: Our research revealed the therapeutic, anti-inflammatory and anti-oxidative effects of PSP on T2DM. The mechanisms of PSP on T2DM are associated with improving the dysbiosis of gut microbiota and regulating arginine and proline metabolism, tryptophan metabolism, and glutathione metabolism in serum.PMID:37038712 | DOI:10.2174/1389200224666230406114012
Source: Current Drug Metabolism - April 11, 2023 Category: Drugs & Pharmacology Authors: Hui Zhang Hanzhou Li Baochao Pan Shufang Zhang Xiuhai Su Wenjuan Sun Tianyu Zhang Zhaiyi Zhang Shuquan Lv Huantian Cui Source Type: research
Recurrent prescription of sleep medication among primary care patients with type 2 diabetes: an observational study of real-world registry data
CONCLUSIONS: Recurrent sleep medication prescriptions are frequent among primary care T2D patients. It seems that sleep disorders are underdiagnosed in relation to this. Primary care clinicians should carefully estimate the need for sleep medication when treating T2D patients' sleep problems and emphasize the diagnostic patterns of sleep problems.PMID:37016350 | DOI:10.1186/s12875-023-02045-1
Source: Primary Care - April 4, 2023 Category: Primary Care Authors: Eveliina Heikkala Jari Jokelainen Ilona Mikkola Juha Auvinen Maria Hagn äs Source Type: research
Melatonin/nicotinamide mononucleotide/ubiquinol: a cocktail providing superior cardioprotection against ischemia/reperfusion injury in a common co-morbidities modelled rat
CONCLUSIONS: Combination therapy with melatonin, NMN, and ubiquinol exerted significant cardioprotection and improved mitochondrial function and biogenesis via upregulation of SIRT-1/PGC-1α/NRF-2/TFAM profiles in aged diabetic rats and, thus, offers a promising strategy for providing noticeable cardioprotection against I/R injury also in aged diabetic patients.PMID:36787055 | DOI:10.1007/s11033-022-08189-0
Source: Molecular Biology Reports - February 14, 2023 Category: Molecular Biology Authors: Behnaz Mokhtari Poul Flemming H øilund-Carlsen Leila Chodari Masoud Yasami Reza Badalzadeh Samad Ghaffari Source Type: research
Interplay between metabolic dysfunction-associated fatty liver disease and chronic kidney disease: Epidemiology, pathophysiologic mechanisms, and treatment considerations
World J Gastroenterol. 2022 Oct 21;28(39):5691-5706. doi: 10.3748/wjg.v28.i39.5691.ABSTRACTThe recently proposed nomenclature change from non-alcoholic fatty liver disease to metabolic dysfunction-associated fatty liver disease (MAFLD) has resulted in the reappraisal of epidemiological trends and associations with other chronic diseases. In this context, MAFLD appears to be tightly linked to incident chronic kidney disease (CKD). This association may be attributed to multiple shared risk factors including type 2 diabetes mellitus, arterial hypertension, obesity, dyslipidemia, and insulin resistance. Moreover, similarities ...
Source: World Journal of Gastroenterology : WJG - November 7, 2022 Category: Gastroenterology Authors: Panagiotis Theofilis Aikaterini Vordoni Rigas G Kalaitzidis Source Type: research
