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Condition: Chronic Kidney Disease
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Total 202 results found since Jan 2013.
SGLT2 inhibitor canagliflozin alleviates vascular calcification through suppression of NLRP3 inflammasome
CONCLUSIONS: Our study for the first time demonstrates that CANA exerts a protective effect on vascular calcification at least partially via suppressing NLRP3 signaling pathway. Therefore, supplementation of CANA as well as inhibition of NLRP3 inflammasome presents a potential therapy for vascular calcification.PMID:37523743 | DOI:10.1093/cvr/cvad119
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: An Chen Zirong Lan Li Li Luting Xie Xiaoyu Liu Xiulin Yang Siyi Wang Qingchun Liang Qianqian Dong Liyun Feng Yining Li Yuanzhi Ye Mingwei Fu Lihe Lu Jianyun Yan Source Type: research
Oxidative stress and inflammation are mediated via aryl hydrocarbon receptor signalling in idiopathic membranous nephropathy
Free Radic Biol Med. 2023 Jul 12:S0891-5849(23)00543-9. doi: 10.1016/j.freeradbiomed.2023.07.014. Online ahead of print.ABSTRACTMembranous nephropathy (MN) patients are diagnosed by the presence of phospholipase A2 receptor (PLA2R) before they progress to renal failure. However, the subepithelium-like immunocomplex deposit-mediated downstream molecular pathways are poorly understood. The aryl hydrocarbon receptor (AHR), NF-ƙB and Nrf2 pathways play central roles in the pathogenesis and progression of chronic kidney disease. However, their mutual effects on MN require further examination. Thus, we investigated the effect o...
Source: Free Radical Biology and Medicine - July 14, 2023 Category: Biology Authors: Yan-Ni Wang Hua Miao Xiao-Yong Yu Yan Guo Wei Su Fei Liu Gang Cao Ying-Yong Zhao Source Type: research
Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
CONCLUSION: Grem1 plays a vital role in nicotine-exacerbated DN. Grem1 may be a potential therapeutic target for chronic smokers with DN.PMID:37415117 | DOI:10.1186/s10020-023-00692-9
Source: Molecular Medicine - July 6, 2023 Category: Molecular Biology Authors: Jianning Chen Haiting Xiao Rui Xue Vinod Kumar Rukhsana Aslam Syed Faizan Mehdi Huairong Luo Ashwani Malhotra Xiqian Lan Pravin Singhal Source Type: research
GADD34 activates p53 and may have utility as a marker of atherosclerosis
Front Med (Lausanne). 2023 May 9;10:1128921. doi: 10.3389/fmed.2023.1128921. eCollection 2023.ABSTRACTWe previously identified growth arrest and DNA-damage-inducible gene 34 (GADD34) as a marker of ischemic stroke. In the present study, serum levels of anti-GADD34 antibodies were found to be significantly higher in patients with acute ischemic stroke or chronic kidney disease compared to healthy donors. We then examined the biological function of GADD34 by transfection into U2OS human osteosarcoma and U87 human glioblastoma cells. Knockdown of GADD34 by siRNA resulted in enhanced cell proliferation, which was reversed by c...
Source: Atherosclerosis - May 25, 2023 Category: Cardiology Authors: Go Tomiyoshi Rika Nakamura Natsuko Shinmen Yoichi Yoshida Seiichiro Mine Toshio Machida Katsuro Iwase Yasuo Iwadate Takaki Hiwasa Hideyuki Kuroda Source Type: research
SDMA attenuates renal tubulointerstitial fibrosis through inhibition of STAT4
CONCLUSION: Taken together, our study indicates that renal SDMA ameliorates renal tubulointerstitial fibrosis through inhibition of STAT4.PMID:37194066 | DOI:10.1186/s12967-023-04181-9
Source: Molecular Medicine - May 16, 2023 Category: Molecular Biology Authors: Yanzhe Wang Ming Wu Dongping Chen Bo Tan Pinglan Lin Di Huang Chaoyang Ye Source Type: research
Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
CONCLUSIONS: The miRNA transcriptomic signature of circulating sEVs uncovered their pathologic role, devoid of the calcification-protective miRNAs that target VEGFA signaling in CKD-driven vascular calcification. These sEV-propagated miRNAs are potential biomarkers and therapeutic targets for vascular calcification.PMID:36700539 | DOI:10.1161/CIRCRESAHA.122.321939
Source: Circulation Research - January 26, 2023 Category: Cardiology Authors: Takaaki Koide Shintaro Mandai Reo Kitaoka Hisazumi Matsuki Motoko Chiga Kouhei Yamamoto Kotaro Yoshioka Yohsuke Yagi Soichiro Suzuki Tamami Fujiki Fumiaki Ando Takayasu Mori Koichiro Susa Soichiro Iimori Shotaro Naito Eisei Sohara Tatemitsu Rai Takanori Y Source Type: research
The mechanosensitive Piezo1 channels contribute to the arterial medial calcification
Vascular calcification (VC) is associated with a number of cardiovascular diseases, as well as chronic kidney disease. The role of smooth muscle cells (SMC) has already been widely explored in VC, as has the role of intracellular Ca2+ in regulating SMC function. Increased intracellular calcium concentration ([Ca2+]i) in vascular SMC has been proposed to stimulate VC. However, the contribution of the non-selective Piezo1 mechanosensitive cation channels to the elevation of [Ca2+]i, and consequently to the process of VC has never been examined. In this work the essential contribution of Piezo1 channels to arterial medial cal...
Source: Frontiers in Physiology - November 10, 2022 Category: Physiology Source Type: research
Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling
In conclusion, SIRT7 alleviates renal ferroptosis, lipid peroxidation, and partial EMT under hypertensive status by facilitating the KLF15/Nrf2 signaling, thereby mitigating renal fibrosis, injury and dysfunction. Targeting SIRT7 signaling serves as a promising strategy for hypertension and hypertensive renal injury.PMID:36334846 | DOI:10.1016/j.freeradbiomed.2022.10.320
Source: Free Radical Biology and Medicine - November 5, 2022 Category: Biology Authors: Xue-Ting Li Jia-Wei Song Zhen-Zhou Zhang Mi-Wen Zhang Li-Rong Liang Ran Miao Ying Liu Yi-Hang Chen Xiao-Yan Liu Jiu-Chang Zhong Source Type: research
