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Condition: Asthma
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Total 404 results found since Jan 2013.
Store-operated Calcium Entry-associated Regulatory Factor Regulates Airway Inflammation and Airway Remodeling in Asthma Mice Models
CONCLUSIONS: SARAF plays a protective role against airway inflammation and remodeling in asthma mice models by blunting SOCE; SARAF may also be a functional regulating factor of hASMCs.PMID:34231388 | DOI:10.1152/ajplung.00079.2020
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - July 7, 2021 Category: Cytology Authors: Yi-Min Wang Wen-Juan Xu Lin-Li Xiang Mei Ding Jin-Jin Zhang Jing-Ya Lu Bao-Juan Xie Ya-Dong Gao Source Type: research
TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts
This study assessed the effect of calcitriol on PRMT1-dependent fibroblast remodeling in human lung fibroblasts, and allergen-induced asthma in E3-rats. Fibroblasts were activated with thymic stromal lymphopoietin (TLSP); asthma was induced by ovalbumin inhalation in rats. The airway structure was assessed by immunohistology. Protein expression in fibroblasts and activation of the mitogen activated protein kinases were detected by Western-blotting. Transcription factor activation was determined by luciferase reporter assay. PRMT1 action was blocked by siRNA and PRMT-inhibition. Ovalbumin upregulated the expression of TSLP,...
Source: Biochimica et Biophysica Acta - June 20, 2021 Category: Biochemistry Authors: Ai Jin Xuemei Tang Weiqi Zhai Yuwen Li Qingzhu Sun Li Liu Xiaojun Yang Hui Ren Shemin Lu Source Type: research
HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway
CONCLUSION: HMSC-exos could inhibit the differentiation of Th2 cells via the regulation of the miR-146a-5p/SERPINB2 pathway. miR-146a-5p and SERPINB2 could be applied as potential targets for AR treatment.PMID:34095322 | PMC:PMC8140841 | DOI:10.1155/2021/6696525
Source: Journal of Immunology Research - June 7, 2021 Category: Allergy & Immunology Authors: Jing Zhou Yi Lu Wei Wu Yunhai Feng Source Type: research
Abnormal ADAM17 expression causes airway fibrosis in chronic obstructive asthma
Biomed Pharmacother. 2021 May 26;140:111701. doi: 10.1016/j.biopha.2021.111701. Online ahead of print.ABSTRACTPatients with chronic obstructive asthma (COA) develop airflow obstruction caused by subepithelial fibrosis. Although a disintegrin and metalloproteinase 17 (ADAM17) has been implicated in lung inflammation and tissue fibrosis, its role in airway fibrosis in COA has not been explored. Here, we found marked overexpression of ADAM17, phosphorylated ADAM17, and connective tissue growth factor (CTGF) in human airway fibroblasts from COA patients, compared with those of normal subjects. Similarly, levels of ADAM17, CTGF...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 29, 2021 Category: Drugs & Pharmacology Authors: Jing-Yun Chen Wun-Hao Cheng Kang-Yun Lee Han-Pin Kuo Kian Fan Chung Chia-Ling Chen Bing-Chang Chen Chien-Huang Lin Source Type: research
Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice
CONCLUSIONS: These data implicate CaSR in CPAP effects on airway function with implications for wheezing in former preterm infants.IMPACT: Neonatal CPAP increases airway reactivity to bronchoconstrictor agonist. CPAP increases smooth muscle expression of the extracellular calcium-sensing receptor (CaSR). Inhibition or absence of CaSR blunts CPAP effects on contractility. These data suggest a causal/contributory role for CaSR in stretch effects on the developing airway. These data may impact clinical recognition of the ways that CPAP may contribute to wheezing disorders of former preterm infants.PMID:33958714 | DOI:10.1038/s41390-021-01540-4
Source: Pediatric Research - May 7, 2021 Category: Pediatrics Authors: Catherine A Mayer Benjamin Roos Jacob Teske Natalya Wells Richard J Martin Wenhan Chang Christina M Pabelick Y S Prakash Peter M MacFarlane Source Type: research
