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Condition: Thrombocytopenia

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Total 366 results found since Jan 2013.

Bevacizumab, temozolomide, and radiotherapy for newly diagnosed glioblastoma: comprehensive safety results during and after first-line therapy
Conclusion The safety profile was consistent with that expected from radiotherapy/temozolomide plus bevacizumab. The increased AE incidence with bevacizumab did not impact patients' ability to receive standard-of-care treatment or to undergo further surgery.
Source: Neuro-Oncology - June 6, 2016 Category: Cancer & Oncology Authors: Saran, F., Chinot, O. L., Henriksson, R., Mason, W., Wick, W., Cloughesy, T., Dhar, S., Pozzi, E., Garcia, J., Nishikawa, R. Tags: Clinical Investigations Source Type: research

Use of Contraindicated Antiplatelet Medications in the Setting of Percutaneous Coronary Intervention: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program Original Articles
Conclusions— In this national cohort, 18% of patients undergoing PCI had contraindications to common antiplatelet medications. Approximately 6% of those patients received a contraindicated medication with attendant bleeding risk, although this did not translate into significantly higher risk of 30-day mortality. Continued efforts to reduce contraindicated medication use may help avoid periprocedural complications.
Source: Circulation: Cardiovascular Quality and Outcomes - July 18, 2016 Category: Cardiology Authors: Barnes, G. D., Stanislawski, M. A., Liu, W., Baron, A. E., Armstrong, E. J., Ho, P. M., Klein, A., Maddox, T. M., Nallamothu, B. K., Rumsfeld, J. S., Tsai, T. T., Bradley, S. M. Tags: Platelets, Anticoagulants, Percutaneous Coronary Intervention, Stent, Quality and Outcomes Original Articles Source Type: research

Preeclampsia, of mice and women
Preeclampsia (PE) is a devastating disorder of pregnancy that affects up to 8% of pregnant women in the United States. The diagnosis of PE is made by the presentation of new-onset hypertension, ≥140 mmHg systolic blood pressure (BP) or ≥90 mmHg diastolic BP, and either proteinuria or another accompanying sign/symptom, such as renal insufficiency, thrombocytopenia, hepatic dysfunction, pulmonary edema, or cerebral/visual. These signs can occur suddenly and without warning. PE that presents before 34 wk of gestation is considered early onset and carries a greater risk for perinatal morbidity/mortality than late-onset P...
Source: Physiological Genomics - July 31, 2016 Category: Genetics & Stem Cells Authors: Sones, J. L., Davisson, R. L. Tags: Call for Papers: Systems Biology and Polygenic Traits Source Type: research

Refractory thrombotic thrombocytopenic purpura following acute pancreatitis
Publication date: Available online 11 August 2016 Source:Journal of Acute Disease Author(s): Ebisa Bekele, Bethel Shiferaw, Alexandra Sokolova, Arpan Shah, Phillip Saunders, Alida Podrumar, Javed Iqbal Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder with an estimated incidence of 4–5 cases per million people per year. It is characterized by small-vessel platelet-rich thrombi that cause thrombocytopenia, microangiopathic hemolytic anemia and organ damage. There are reports in literature that TTP and acute pancreatitis are associated, indicating each can be the cause of the other. However, acute pancrea...
Source: Journal of Acute Disease - August 11, 2016 Category: Emergency Medicine Source Type: research

P08.46 Rechallenge with bevacizumab in a long-term survivor with glioblastoma
The prognosis of patients with glioblastoma multiforme (GBM, WHO grade IV), the most common primary brain tumor in adults, is generally poor with median survival of less than one year in untreated patients and approximately 15 months following standard of care therapy. However, 10 % survival at 5 years was observed in a randomized phase III study. At GBM recurrence, the addition of bevacizumab (BEV), a humanized monoclonal antibody against circulating vascular endothelial growth factor (VEGF), resulted in a 3–4 month prolongation of progression-free survival (PFS) without improving overall survival (OS...
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Koeppen, S., Hense, J. Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research

Borderline operability in hepatectomy patients is associated with higher rates of failure to rescue after severe complications
ConclusionsHepatectomy patients meeting BL criteria have an overall post‐hepatectomy mortality rate that is triple that of non‐BL patients. With less clinical reserve, BL patients who suffer SC are at greater risk of post‐hepatectomy death. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc.
Source: Journal of Surgical Oncology - November 2, 2016 Category: Cancer & Oncology Authors: Bradford J. Kim, Ching ‐Wei D. Tzeng, Amanda B. Cooper, Jean‐Nicolas Vauthey, Thomas A. Aloia Tags: Research Article Source Type: research

Atim-18. phase i dose escalation study of d2c7-it administered intratumorally via convection-enhanced delivery (ced) for recurrent malignant glioma (mg)
CONCLUSION:Infusion of D2C7-IT via CED is safe thus far and encouraging efficacy results are observed. Enrollment is ongoing.
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Desjardins, A., Randazzo, D., Chandramohan, V., Sampson, J., Peters, K., Vlahovic, G., Threatt, S., Herndon, J., Boulton, S., Lally-Goss, D., Healy, P., Lipp, E., Friedman, A., Friedman, H., Bigner, D. Tags: ADULT CLINICAL TRIALS (IMMUNOLOGICAL) Source Type: research

Recurrent cerebral venous sinus thrombosis secondary to eltrombopag for itp
Conclusion Extensive chronic cerebral venous sinus thrombosis likely caused by abnormally structured platelets may result when Eltrombopag increases their number.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Mallick, S., Janarthen, V., Warner, G. Tags: Cranial nerves, Headache (including migraine), Pain (neurology), Stroke, Ophthalmology ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Thrombocytopenia with stroke-smear surprise
Publication date: Available online 30 March 2017 Source:European Geriatric Medicine Author(s): M. Shahid
Source: European Geriatric Medicine - March 31, 2017 Category: Geriatrics Source Type: research

Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research

Intra-arterial chemotherapy for retinoblastoma: Two-year results from tertiary eye-care center in India
Conclusions: IAC is an effective therapy for globe preservation in eyes with intraocular RB, in the setting of a developing country like India. Larger studies with longer follow-up are required to validate these results.
Source: Indian Journal of Ophthalmology - May 17, 2017 Category: Opthalmology Authors: Pukhraj Rishi Tarun Sharma Minal Sharma Aditya Maitray Abhinav Dhami Vishvesh Aggarwal Saravanan Munusamy R Ravikumar Satheesh Ramamurthy Source Type: research

Thrombocytopenia induced by dabigatran: two case reports
Vitamin K inhibitors (e.g. warfarin) and indirect thrombin inhibitors (e.g. heparin) are widely used to prevent thromboembolic disorders (e.g. myocardial infarction, venous thromboembolism, and stroke). These ...
Source: BMC Neurology - June 29, 2017 Category: Neurology Authors: Hyun Goo Kang, Seung Jae Lee, Ji Yeon Chung and Jin Sung Cheong Source Type: research

Recognition and Management of Preeclampsia
Publication date: July 2017 Source:Hospital Medicine Clinics, Volume 6, Issue 3 Author(s): Christine M. CombsTeaser Preeclampsia is a multisystem disorder of new-onset hypertension in the second half of pregnancy associated with abnormalities in several organ systems. Manifestations of maternal vascular endothelial dysfunction include proteinuria, thrombocytopenia, microangiopathic hemolysis, pulmonary edema, hepatic ischemia, hypercoagulability, stroke, and seizure. Preeclampsia is common, with a worldwide prevalence of 2% to 8%, and 3% to 5% of all US pregnancies, with prevalence in primiparous pregnancies approximately...
Source: Hospital Medicine Clinics - June 30, 2017 Category: Internal Medicine Source Type: research

Successful kidney transplantation in a patient with congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome).
CONCLUSION: Our experience suggests that kidney transplantation may be an appropriate management for carefully selected patients with congenital TTP who develop end-stage renal disease. PMID: 28940540 [PubMed - as supplied by publisher]
Source: Transfusion - September 20, 2017 Category: Hematology Authors: Fattah H, Kumar D, George JN, Massey HD, King AL, Friedman KD, Gupta G Tags: Transfusion Source Type: research

Management of phenytoin-induced gingival enlargement in a patient with antiphospholipid antibody syndrome: A rare case report
Shilpa Sarvesh Urolagin, Deepthi Swaroop, Charu Agrawal, Pathik Dholakia, Menaka Basavanneppa KaralwadJournal of Indian Society of Periodontology 2016 20(5):561-564 Antiphospholipid antibody (APLA) syndrome is a noninflammatory autoimmune disease, with innumerable clinical manifestations ranging from recurrent thrombosis and pregnancy morbidity to valvular lesions, transverse myelitis, thrombocytopenia, and hemolytic anemia. APLAs in antiphospholipid syndrome (APS) are well-known risk factors for cerebrovascular accidents. Stroke is the most common manifestation of APS in the central nervous system. Gingival enlargement i...
Source: Journal of Indian Society of Periodontology - October 17, 2017 Category: Dentistry Authors: Shilpa Sarvesh Urolagin Deepthi Swaroop Charu Agrawal Pathik Dholakia Menaka Basavanneppa Karalwad Source Type: research