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Sexual and reproductive health needs of young women living with perinatally acquired HIV
CONCLUSION: High rates of unplanned pregnancy, STIs and cervical abnormalities highlight the continuing SRH needs of YWLPaHIV and requirement for open access to integrated HIV/SRH services despite pandemic restrictions.PMID:37279784 | DOI:10.1177/09564624231179768
Source: Herpes - June 6, 2023 Category: Infectious Diseases Authors: Veronica R Nott George A Hazell Sara Ayres Natalie Kirkhope Sarah Fidler Caroline Foster Source Type: research

Response to HIV-1 gp160-carrying recombinant virus HSV-1 and HIV-1 VLP combined vaccine in BALB/c mice
Front Microbiol. 2023 Mar 17;14:1136664. doi: 10.3389/fmicb.2023.1136664. eCollection 2023.ABSTRACTHuman immunodeficiency virus (HIV) induced AIDS causes a large number of infections and deaths worldwide every year, still no vaccines are available to prevent infection. Recombinant herpes simplex virus type 1 (HSV-1) vector-based vaccines coding the target proteins of other pathogens have been widely used for disease control. Here, a recombinant virus with HIV-1 gp160 gene integration into the internal reverse (IR) region-deleted HSV-1 vector (HSV-BAC), was obtained by bacterial artificial chromosome (BAC) technology, and i...
Source: Herpes - April 3, 2023 Category: Infectious Diseases Authors: Beibei Zhang Hongyan Mao Hongjuan Zhu Jingxia Guo Paul Zhou Zhenghai Ma Source Type: research

Immunisation Using Novel DNA Vaccine Encoding Virus Membrane Fusion Complex and Chemokine Genes Shows High Protection from HSV-2
Viruses. 2022 Oct 22;14(11):2317. doi: 10.3390/v14112317.ABSTRACTHerpes simplex virus 1 and 2 infections cause high unmet disease burdens worldwide. Mainly HSV-2 causes persistent sexually transmitted disease, fatal neonatal disease and increased transmission of HIV/AIDS. Thus, there is an urgent requirement to develop effective vaccines. We developed nucleic acid vaccines encoding a novel virus entry complex stabilising cell membrane fusion, 'virus-like membranes', VLM. Two dose intramuscular immunisations using DNA expression plasmids in a guinea pig model gave 100% protection against acute disease and significantly redu...
Source: Herpes - November 11, 2022 Category: Infectious Diseases Authors: Ursula A Gompels Fernando J Bravo Sean Briggs Shima Ameri Rhonda D Cardin David I Bernstein Source Type: research

Male circumcision and Sexually transmitted Infections & #8211; An update
Kajal S Mehta, Yogesh S Marfatia, Apexa P Jain, Dhiral J Shah, Disha S BaxiIndian Journal of Sexually Transmitted Diseases and AIDS 2021 42(1):1-6Role of male circumcision (MC) as a tool to prevent sexually transmitted infections (STIs)/human immunodeficiency virus (HIV) was assessed. An attempt was made to search articles related to association between MC and STIs/HIV. A thorough search was carried out to find out quality articles published in indexed specialty journals. Centers for Disease Control and Prevention and World Health Organization (WHO) sites were also referred. Warm and moist environment of area under foreski...
Source: Indian Journal of Sexually Transmitted Diseases - May 4, 2021 Category: Infectious Diseases Authors: Kajal S Mehta Yogesh S Marfatia Apexa P Jain Dhiral J Shah Disha S Baxi Source Type: research

SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - April 10, 2019 Category: Allergy & Immunology Source Type: research

Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial
Conclusions: These finding suggest that Poly-ICLC could be safely used for inducing transient innate immune responses in treated HIV+ subjects indicating promise as an adjuvant for HIV therapeutic vaccines. Trial Registration: www.ClinicalTrials.gov, identifier: NCT02071095. Introduction Innate immune dysregulation during HIV infection hinders the formation of anti-HIV adaptive immunity (1–6) resulting in rampant viral dissemination and progression to AIDS. Adherence to combination anti-retroviral therapy (cART) regimens controls viremia, restores CD4+T cell counts and reverses immune dysfunction to ...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research